N4-Acetylcytidine

Product Name: N4-Acetylcytidine
CAS No.: 3768-18-1
Chemical Name: N4-Acetylcytidine
Synonyms: N-Acetylcytidine;Ac-rC;Acetylcytidine;rC(Ac);N4-Ac-rC;N4-Ac-Cr;ACETYL CYTOSINE;n-acetyl-cytidin;4-Acetylcytidine;N4-ACETYLCYTIDINE
CBNumber: CB1207392
Molecular Formula: C11H15N3O6
Formula Weight: 285.25
MOL File: 3768-18-1.mol

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N4-Acetylcytidine Property

Melting point:: 199 °C (dec.)(lit.)
Density: 1.72±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO (Slightly, Heated), Methanol (Slightly, Heated)
form: Solid
pka: 10.21±0.20(Predicted)
color: White to Pale Yellow
PH: ＜1.5
λmax: 247，297 (pH 7)
CAS DataBase Reference: 3768-18-1(CAS DataBase Reference)
NIST Chemistry Reference: Cytidine, n-acetyl-(3768-18-1)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 36-36/37/39-26
WGK Germany: 3
HS Code: 29335990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: N633048
Product name: N4-Acetylcytidine
Packaging: 1g
Price: $50
Updated: 2021/12/16

TRC

Product number: N633048
Product name: N4-Acetylcytidine
Packaging: 10g
Price: $145
Updated: 2021/12/16

Usbiological

Product number: 295170
Product name: N4-Acetylcytidine
Packaging: 10g
Price: $319
Updated: 2021/12/16

Matrix Scientific

Product number: 098466
Product name: N-Acetylcytidine
Purity: 95+%
Packaging: 10g
Price: $395
Updated: 2021/12/16

Ark Pharm

Product number: P000182579
Product name: N-Acetylcytidine
Purity: 97%
Packaging: 100g
Price: $263
Updated: 2021/12/16

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N4-Acetylcytidine Chemical Properties,Usage,Production

Description

N4-Acetylcytidine is a modified nucleoside and endogenous urinary nucleoside product of the degradation of tRNA. N4-Acetylcytidine is a biological marker for various cancers with elevated concentrations present in urine. tRNA has been shown to be excreted in abnormal amounts in the urine of cancer patients. tRNA from neoplastic tissue had a much more rapid turnover rate than the tRNA from the corresponding normal tissue. Evidence indicates that methylation of tRNA occurs only after synthesis of the intact macromolecule. Because there are no specific enzyme systems to incorporate the modified nucleosides into the macromolecular nucleic acid, these nucleosides once released in the process of tRNA turnover cannot be reutilized, nor are they further degraded, but are excreted in urine.
N4-Acetylcytidine is also a partially protected cytidine and therefore can be used as a synthetic building block to prepare further derivatized nucleosides such as 2’,3’-dideoxycytidine.

Uses

N4-Acetylcytidine (cas# 3768-18-1) is a nucleotide-derived metabolite used as biomarkers for diagnosis of inflammation-related diseases.

Definition

ChEBI: N(4)-acetylcytidine is cytidine in which one of the exocyclic amino hydrogens is substituted by an acetyl group. It has a role as a metabolite. It is a member of cytidines, a member of acetamides and a secondary carboxamide.

Biosynthesis

N4-acetylcytidine (ac4C) is a post-transcriptional modification of RNA that is conserved across all domains of life. All characterized sites of ac4C in eukaryotic RNA occur in the central nucleotide of a 5’-CCG-3’ consensus sequence. However, the thermodynamic consequences of cytidine acetylation in this context have never been assessed due to its challenging synthesis. Here we report the synthesis and biophysical characterization of ac4C in its endogenous eukaryotic sequence context. First, we develop a synthetic route to homogenous RNAs containing electrophilic acetyl groups. Next, we use thermal denaturation to interrogate the effects of ac4C on duplex stability and mismatch discrimination in a native sequence found in human ribosomal RNA. Finally, we demonstrate the ability of this chemistry to incorporate ac4C into the complex modification landscape of human tRNA, and use duplex melting combined with sequence analysis to highlight a potentially unique enforcing role for ac4C in this setting. By enabling the analysis of nucleic acid acetylation in its physiological sequence context, these studies establish a chemical foundation for understanding the function of a universally-conserved nucleobase in biology and disease.
Site-Specific Synthesis of N4-Acetylcytidine in RNA Reveals Physiological Duplex Stabilization
https://www.biorxiv.org/content/10.1101/2021.11.12.468326v1.full.pdf

N4-Acetylcytidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N4-Acetylcytidine Suppliers

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View Lastest Price from N4-Acetylcytidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: N4-Acetylcytidine 3768-18-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-23

Zhuozhou Wenxi import and Export Co., Ltd

Product: N4-Acetylcytidine 3768-18-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-08-11

Career Henan Chemical Co

Product: N4-Acetylcytidine 3768-18-1
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-15

3768-18-1, N4-AcetylcytidineRelated Search:

Fluorocytosine 1-(5-Pyrimidinyl)ethanone Acetylcholine Acetaminophen Acetyl chloride Isocytosine Cytosine Acetylacetone Acetylspiramycin N4-Benzoylcytidine 2-Methyl-4-amino-5-acetylaminomethyl pyrimidine N4-Acetylcytosine N4-BENZOYL-2'-O-METHYLCYTIDINE 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]-N-[[4-(tert-butyl)phenoxy]acetyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite N4-BENZOYL-5'-O-DMT-CYTIDINE Cytidine N-blocked-5'-O-DMT-2'-O-Me CED cytosine phosphoramidite N4-ACETYL-5'-(DIMETHOXYTRITYL)-2'-O-METHYLCYTIDINE

4-Acetyl-1-(beta-D-ribofuranosyl)cytosine

ACETYL CYTOSINE

N4-ACETYLCYTIDINE

4-Acetylcytidine

Acetamide, N-(1,2-dihydro-2-oxo-1-beta-D-ribofuranosyl-4-pyrimidinyl)-

Acetylcytidine

N4-Ac-rC

n-acetyl-cytidin

N-Acetylcytidine

N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxo-pyrimidin-4-yl]ethanamide

N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]-2-keto-pyrimidin-4-yl]acetamide

Ac-rC

N4-Acetyl-D-cytidine

N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

N4 CACETYLCYTIDINE

N(sup 4)-acetylcytidine

N<sup>4</sup>-Acetylcytidine

N4-Ac-Cr

N<sup>4</sup>-Acetylcytidine, 97.5%

N4-Acetylcytidine, 97.5%

Cytidine, N-acetyl-

N4-Acetylcytidine USP/EP/BP

N4-Acetyl cytidine,RNA modified nucleoside ac4C

RNA modified nucleoside ac4C

rC(Ac)

Cytidine Impurity 1 (N4-Acetylcytidine)

3768-18-1

C11H15N3O6

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Biochemicals and Reagents

BioChemical

Biochemicals and Reagents

Nucleoside Analogs

Nucleosides, Nucleotides, Oligonucleotides

Nucleic acids

Modified（deoxy）nucleoside