ChemicalBook > CAS DataBase List > PENTAETHYLENE GLYCOL MONOMETHYL ETHER

PENTAETHYLENE GLYCOL MONOMETHYL ETHER

Product Name
PENTAETHYLENE GLYCOL MONOMETHYL ETHER
CAS No.
23778-52-1
Chemical Name
PENTAETHYLENE GLYCOL MONOMETHYL ETHER
Synonyms
2,5,8,11,14-Pentaoxahexadecan-16-ol;MPEG-5;MPEG5-OH;MPEG11-NH2;m-PEG5-alcohol;HO-(CH2CH2O)5-Me;Methyl-PEG5-alcohol;2,5,8,11,14,17,20,23;3,6,9,12,15-pentaoxahexadecenol;3,6,9,12,15-Pentaoxahexadecanol
CBNumber
CB1211919
Molecular Formula
C11H24O6
Formula Weight
252.3
MOL File
23778-52-1.mol
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PENTAETHYLENE GLYCOL MONOMETHYL ETHER Property

Boiling point:
110 °C(Press: 0.01 Torr)
Density 
1.08
refractive index 
1.4480 to 1.4520
storage temp. 
-20°C
form 
clear liquid
pka
14.36±0.10(Predicted)
color 
Colorless to Light yellow to Light orange
InChI
InChI=1S/C11H24O6/c1-13-4-5-15-8-9-17-11-10-16-7-6-14-3-2-12/h12H,2-11H2,1H3
InChIKey
SLNYBUIEAMRFSZ-UHFFFAOYSA-N
SMILES
C(O)COCCOCCOCCOCCOC
CAS DataBase Reference
23778-52-1
EPA Substance Registry System
2,5,8,11,14-Pentaoxahexadecan-16-ol (23778-52-1)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
2909.49.6000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
P1159
Product name
Pentaethylene Glycol Monomethyl Ether
Purity
>96.0%(GC)
Packaging
1g
Price
$158
Updated
2025/07/31
TCI Chemical
Product number
P1159
Product name
Pentaethylene Glycol Monomethyl Ether
Purity
>96.0%(GC)
Packaging
5g
Price
$517
Updated
2025/07/31
Chem-Impex
Product number
41726
Product name
Pentaethyleneglycolmonomethylether,≥96%(GC)
Purity
≥96%(GC)
Packaging
1G
Price
$171.23
Updated
2021/12/16
BroadPharm
Product number
BP-22068
Product name
m-PEG5-alcohol
Purity
98%
Packaging
5G
Price
$180
Updated
2021/12/16
BroadPharm
Product number
BP-22068
Product name
m-PEG5-alcohol
Purity
98%
Packaging
10g
Price
$315
Updated
2021/12/16
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PENTAETHYLENE GLYCOL MONOMETHYL ETHER Chemical Properties,Usage,Production

Description

m-PEG5-alcohol is a PEG linker containing a hydroxyl group. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer increases solubility in aqueous media.

Uses

Applications may include: bioconjugation, drug delivery, PEG hydrogel, crosslinker, and surface functionalization

Synthesis

112-60-7

6482-24-2

23778-52-1

The general procedure for the synthesis of pentaethylene glycol monomethyl ether from tetraethylene glycol truncated and 2-bromoethyl methyl ether was as follows: tetraethylene glycol (55 mmol, 10.7 g) was dissolved in 100 mL of tetrahydrofuran (THF), and potassium tert-butoxide (KOtBu, 55 mL, 1.0 M solution in THF) was added to this solution at room temperature. The resulting mixture was stirred at room temperature for 30 min, followed by the slow dropwise addition of 2-bromoethyl methyl ether (55 mmol, 5.17 mL, dissolved in 50 mL THF). The reaction mixture was stirred overnight at room temperature and then extracted with 300 mL of water and 3 x 300 mL of dichloromethane. The organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). The desiccant was removed by filtration and after evaporation of the solvent, the crude product was purified using silica gel column chromatography (eluent ratio CH2Cl2:CH3OH = 60:140:1) to afford pure pentaethylene glycol monomethyl ether (35% yield).1H NMR (CDCl3) δ 3.75-3.42 (m, 20H, OCH2CH2O), 3.39 (s, 3H MeO).

IC 50

PEGs

References

[1] Patent: US2005/136031, 2005, A1. Location in patent: Page/Page column 25

PENTAETHYLENE GLYCOL MONOMETHYL ETHER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PENTAETHYLENE GLYCOL MONOMETHYL ETHER manufacturers

LAURENT
Product
mPEG5-OH 23778-52-1
Price
US $3458.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
500kg
Release date
2025-11-20
Xian confluore Biological Technology Co., Ltd.
Product
m-PEG5-alcohol 23778-52-1
Price
US $0.00/g
Min. Order
100g
Purity
>98.00%
Supply Ability
100g
Release date
2024-03-27
Career Henan Chemical Co
Product
(10-Phenyl-9-anthracenyl)boronic acid pinacol ester 23778-52-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-09

23778-52-1, PENTAETHYLENE GLYCOL MONOMETHYL ETHERRelated Search:


  • PENTAETHYLENE GLYCOL MONOMETHYL ETHER
  • 2,5,8,11,14-Pentaoxahexadecan-16-ol
  • 2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]ethanol
  • 3,6,9,12,15-Pentaoxahexadecanol
  • PENTAETHYLENE GLYCOL MONOMETHYL ETHER 96+%
  • POLYETHYLENEGLYCOLMONOMETHYLETHER(N=5)
  • 3,6,9,12,15-pentaoxahexadecenol
  • 2,5,8,11,14,17,20,23,26,29,32-Undecaoxatetratriacontan-34-aMine
  • MPEG11-NH2
  • MPEG5-OH
  • MPEG-5
  • 3,6,9,12,15-Pentaoxahexadecan-1-ol
  • m-PEG5-alcohol
  • Methyl-PEG5-alcohol
  • 2,5,8,11,14,17,20,23
  • PentaethyleneGlycolMonomethylEther&gt
  • PENTAETHYLENE GLYCOL MONOMETHYL ETHER ISO 9001:2015 REACH
  • HO-(CH2CH2O)5-Me
  • mPEG5-OH/3,6,9,12,15-Pentaoxahexadecan-1-ol
  • PENTAETHYLENE GLYCOL MONOMETHYL ETHE
  • 23778-52-1
  • C11H24O6
  • Monofunctional Ethylene Glycols
  • Ethylene Glycols & Monofunctional Ethylene Glycols
  • Ethylene Glycols & Monofunctional Ethylene Glycols
  • Monofunctional Ethylene Glycols
  • PEG-COOH
  • peg