5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
- Product Name
- 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
- CAS No.
- 849550-05-6
- Chemical Name
- 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine
- Synonyms
- TTI237;TTI 237;D06576.;CS-1680;Cevipabulin;TTI237; D06576;Unii-p14m0dws2j;Cevipabulin (TTI-237);Cevipabulin (free base);TTI 237; TTI237; TTI237; D06576.
- CBNumber
- CB12128710
- Molecular Formula
- C18H18ClF5N6O
- Formula Weight
- 464.82
- MOL File
- 849550-05-6.mol
5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Property
- Density
- 1.52
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-4196
- Product name
- Cevipabulin
- Purity
- 99.03%
- Packaging
- 5mg
- Price
- $168
- Updated
- 2021/12/16
- Product number
- CS-4196
- Product name
- Cevipabulin
- Purity
- 99.03%
- Packaging
- 10mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- API0013853
- Product name
- CEVIPABULIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $330
- Updated
- 2021/12/16
- Product number
- CS-4196
- Product name
- Cevipabulin
- Purity
- 99.03%
- Packaging
- 50mg
- Price
- $888
- Updated
- 2021/12/16
- Product number
- CS-4196
- Product name
- Cevipabulin
- Purity
- 99.03%
- Packaging
- 100mg
- Price
- $1140
- Updated
- 2021/12/16
5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Chemical Properties,Usage,Production
Biological Activity
cevipabulin (tti-237) is a new anti-microtubule agent [1][2][3][4].microtubules are a component of the cytoskeleton that participate in many crucial cellular functions, include maintaining the structure of the cell, forming the cytoskeleton and chromosome separation.cevipabulin (tti-237) is a new anti-microtubule agent with antitumor activity. in colo 205 cells, tti-237 inhibited cell proliferation with ic50 value of 31 nm [1]. at low ratios of tti-237: tubulin heterodimer (about 1:30), tti-237 increased depolymerization kinetics in response to low temperature, but stabilized the aggregates at high ratios (about 1:4). tti-237 inhibited the exchange of [3h]gtp at the exchangeable nucleotide site of the tubulin heterodimer [2]. cevipabulin (tti-237) increased tubulin polymerization. cevipabulin was stable and water-soluble, and could be administered i.v. or p.o. in saline [3]. tti-237 inhibited the binding of [3h]vinblastine to tubulin, but significantly increased turbidity development that more closely resembled the effect of docetaxel. in hela cells, tti-237 (34 nmol/l) induced multiple spindle poles and multi-nuclear cells. at 20-40 nmol/l, tti-237 produced sub-g1 nuclei, while at > 50 nmol/l, tti-237 induced g2-m block.in athymic mice bearing lovo human colon adenocarcinoma, tti-237 exhibited good antitumor activity in a dose-dependent way. in mice bearing u87-mg human glioblastoma, tti-237 (25 mg/kg) given both i.v. and p.o. were equally effective [4].
References
[1]. zhang n, ayral-kaloustian s, nguyen t, et al. 2-cyanoaminopyrimidines as a class of antitumor agents that promote tubulin polymerization. bioorg med chem lett, 2007, 17(11): 3003-3005.
[2]. beyer cf, zhang n, hernandez r, et al. the microtubule-active antitumor compound tti-237 has both paclitaxel-like and vincristine-like properties. cancer chemother pharmacol, 2009, 64(4): 681-689.
[3]. ayral-kaloustian s, zhang n, beyer c. cevipabulin (tti-237): preclinical and clinical results for a novel antimicrotubule agent. methods find exp clin pharmacol, 2009, 31(7): 443-447.
[4]. beyer cf, zhang n, hernandez r, et al. tti-237: a novel microtubule-active compound with in vivo antitumor activity. cancer res, 2008, 68(7): 2292-2300.
5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Suppliers
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View Lastest Price from 5-Chloro-6-[2,6-difluoro-4-[3-(methylamino)propoxy]phenyl]-N-((1S)-2,2,2-trifluoro-1-methylethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine manufacturers
- Product
- Cevipabulin 849550-05-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Cevipabulin 849550-05-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- Cevipabulin 849550-05-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30