CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE
- Product Name
- CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE
- CAS No.
- 13051-01-9
- Chemical Name
- CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE
- Synonyms
- statimo;adrenosem;andenogen;adrestat-f;adrenosemsalicylate;CARBAZOCHROME SODIUM;ne5-semicarbazone(1:1);salicylicacid,adrenosem;CARBAZOCHROME SALICYLATE;adrenochrome semicarbazone salicylate
- CBNumber
- CB1212916
- Molecular Formula
- C10H17N4NaO8S
- Formula Weight
- 376.32
- MOL File
- 13051-01-9.mol
CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE Property
- Melting point:
- 196-197.5° (dec)
N-Bromosuccinimide Price
- Product number
- CHM0013968
- Product name
- CARBAZOCHROME SALICYLATE
- Purity
- 95.00%
- Packaging
- 1KG
- Price
- $7755.54
- Updated
- 2021/12/16
CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE Chemical Properties,Usage,Production
Originator
Adrenosem,Beecham,US,1953
Uses
Carbazochrome salicylate is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome salicylate is an antihemorrhagic agent[1].
Manufacturing Process
A suspension containing 1 part by weight of adrenalin and 2 to 6 parts by weight of silver oxide in 150 to 250 parts by weight of methanol or ethanol is stirred for about 10 minutes. The alcoholic adrenochrome solution obtained is separated by draining and the filtrate is quickly evaporated to dryness at low temperature and in vacuo. The red crystals of adrenochrome obtained are dissolved in 45 to 55 parts by weight of water. To this solution, 2 parts of sodium acetate dissolved in 2 to 3 parts of water and 2 parts of semicarbazide hydrochloride dissolved in 2 to 3 parts of water are added. The formed precipitate consisting of red-orange prismatic needles is separated by filtration and recrystallized from diluted ethanol. There is obtained 0.30 to 0.40 part by weight of adrenochrome monosemicarbazone dihydrate, melting at 203°C with decomposition.
Therapeutic Function
Hemostatic
References
[1] Toshiaki Sendo, et al. Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. DOI:10.1007/s00210-003-0785-5
[2] Toshiaki Sendo, et al. Carbazochrome attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats. Eur J Pharmacol. 2002 Aug 23;450(2):203-8. DOI:10.1016/s0014-2999(02)02120-9
CARBAZOCHROME SODIUM SULFONATE TRIHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
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