yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide

Product Name: yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide
CAS No.: 639090-55-4
Chemical Name: yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide
Synonyms: Benzenesulfonylchloride,4-(acetylamino)-7-chloro-;N-(4-(4-Chloro-6-(3-methyl-1H-pyrazol-5-ylamino)-pyrimidin-2-ylthio)phenyl)cyclopropanecarboxa;N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide;N-[4-[[4-Chloro-6-[(5-methyl-3-pyrazolyl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide;N-(4-((4-Chloro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide;N-[4-[[4-Chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide;Cyclopropanecarboxamide, N-[4-[[4-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-;N-[4-({4-chloro-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropane carboxamide;yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide;cyclopropane carboxylic acid {4-[4-chloro-6-(5-Methyl-2H-pyrazol-3-ylaMino)-pyriMidin-2-ylsulphanyl]-phenyl} aMide
CBNumber: CB12131284
Molecular Formula: C18H17ClN6OS
Formula Weight: 400.89
MOL File: 639090-55-4.mol

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yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide Property

Density: 1.49
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 13.85±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: HCH0354407
Product name: N-(4-(4-CHLORO-6-(3-METHYL-1H-PYRAZOL-5-YLAMINO)PYRIMIDIN-2-YLTHIO)PHENYL)CYCLOPROPANECARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $495.28
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0354407
Product name: N-(4-(4-CHLORO-6-(3-METHYL-1H-PYRAZOL-5-YLAMINO)PYRIMIDIN-2-YLTHIO)PHENYL)CYCLOPROPANECARBOXAMIDE
Purity: 95.00%
Packaging: 1G
Price: $1062.6
Updated: 2021/12/16

Matrix Scientific

Product number: 143779
Product name: N-(4-(4-Chloro-6-(3-methyl-1H-pyrazol-5-ylamino)-pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide
Purity: 95%
Packaging: 1g
Price: $2040
Updated: 2021/12/16

Matrix Scientific

Product number: 143779
Product name: N-(4-(4-Chloro-6-(3-methyl-1H-pyrazol-5-ylamino)-pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide
Purity: 95%
Packaging: 5g
Price: $4556
Updated: 2021/12/16

AK Scientific

Product number: 9792AB
Product name: N-(4-((4-Chloro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide
Packaging: 5g
Price: $6200
Updated: 2021/12/16

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yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide Chemical Properties,Usage,Production

Definition

ChEBI: N-[4-[[4-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide is an aryl sulfide.

Synthesis

639090-53-2

31230-17-8

639090-55-4

[4-(4,6-Dichloropyrimidin-2-ylsulfonyl)phenyl]methanaminocyclopropanecarboxylic acid (3.0 g, 8.85 mmol) and 3-amino-5-methyl-1H-pyrazole (0.94 g, 9.7 mmol) were mixed in DMF (16 mL) with diisopropylethylamine (1.25 g, 9.7 mmol) and potassium iodide (1.76 g, 10.6 mmol). The reaction mixture was stirred at 50 °C for 6 hours. After completion of the reaction, the solvent was removed by evaporation under reduced pressure and the residue was purified by recrystallization from ethyl acetate. The target product N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfonyl]phenyl]aminocyclopropanecarboxylic acid (2.0 g, 91% yield) was obtained as a white solid.LC-MS (m/z): 401 [M + 1]+; 1H NMR (DMSO-d6) δ: 0.82 (d, J = 6.6 Hz, 4H) ), 1.85 (m, 1H), 1.99 (s, 1H), 5.24 (bs, 1H), 6.47 (bs, 1H), 7.55 (m, 2H), 7.71 (m, 2H), 10.22 (s, 1H), 11.95 (s, 1H).

References

[1] Patent: WO2009/86012, 2009, A1. Location in patent: Page/Page column 56; 57
[2] Patent: WO2007/14250, 2007, A2. Location in patent: Page/Page column 18
[3] Patent: WO2008/13807, 2008, A2. Location in patent: Page/Page column 7
[4] Patent: WO2007/136615, 2007, A2. Location in patent: Page/Page column 33-34
[5] Patent: US2009/105270, 2009, A1

yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide Preparation Products And Raw materials

Raw materials

Preparation Products

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yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide Suppliers

China 22 United States 2 Global 24

Jinan Trio PharmaTech Co., Ltd.

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Country: China
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ChemShuttle, Inc.

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Email: sales@chemshuttle.com
Country: China
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DebyeTec.com Inc.

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Amadis Chemical Company Limited

Tel: 571-89925085
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Email: sales@amadischem.com
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Aikon International Limited

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Wuhan FengyaoTonghui Chemical Products Co., Ltd.

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Angel Pharmatech, Ltd.

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Jinan Ruisi Pharmaceutical Technology Co., LTD

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Shenyang Maud Pharmaceutical Technology Co., Ltd.

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CONIER CHEM AND PHARMA LIMITED

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639090-55-4, yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amideRelated Search:

yclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide

Cyclopropanecarboxylic acid N-[4-[[4-chloro-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-yl]sulfanyl]phenyl]amide

N-(4-(4-chloro-6-(3-methyl-1H-pyrazol-5-ylamino)pyrimidin-2-ylthio)phenyl)cyclopropanecarboxamide

N-[4-[[4-Chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide

N-(4-(4-Chloro-6-(3-methyl-1H-pyrazol-5-ylamino)-pyrimidin-2-ylthio)phenyl)cyclopropanecarboxa

N-(4-((4-Chloro-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide

cyclopropane carboxylic acid {4-[4-chloro-6-(5-Methyl-2H-pyrazol-3-ylaMino)-pyriMidin-2-ylsulphanyl]-phenyl} aMide

N-[4-({4-chloro-6-[(3-methyl-1H-pyrazol-5-yl)amino]pyrimidin-2-yl}sulfanyl)phenyl]cyclopropane carboxamide

Cyclopropanecarboxamide, N-[4-[[4-chloro-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]-

Benzenesulfonylchloride,4-(acetylamino)-7-chloro-

N-[4-[[4-Chloro-6-[(5-methyl-3-pyrazolyl)amino]-2-pyrimidinyl]thio]phenyl]cyclopropanecarboxamide

639090-55-4