ChemicalBook > CAS DataBase List > 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione

1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione

Product Name
1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione
CAS No.
69431-87-4
Chemical Name
1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione
Synonyms
AM2947;AM-2947;AM 2947;A-39183B;Setomimycin;Antibiotic A-39183B;SetoMiMycin [SetoMiMicin];1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione;[9,9'-Bianthracene]-4,4'(1H,1'H)-dione, 1,1'-diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl- (9CI)
CBNumber
CB12139255
Molecular Formula
C34H28O9
Formula Weight
580.58
MOL File
69431-87-4.mol
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1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Property

Boiling point:
765.2±60.0 °C(Predicted)
Density 
1.479±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Chloroform: soluble; DMSO: soluble
form 
A solid
pka
3.61±0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27958
Product name
Setomimycin
Purity
≥95%
Packaging
1 mg
Price
$79
Updated
2024/03/01
Cayman Chemical
Product number
27958
Product name
Setomimycin
Packaging
5mg
Price
$298
Updated
2022/04/27
Usbiological
Product number
207402
Product name
Setomimycin
Packaging
1mg
Price
$316
Updated
2021/12/16
TRC
Product number
S280803
Product name
Setomimycin
Packaging
2.5mg
Price
$745
Updated
2021/12/16
AK Scientific
Product number
2554CB
Product name
Setomimycin
Packaging
5mg
Price
$471
Updated
2021/12/16
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1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Chemical Properties,Usage,Production

Uses

Setomimycin is a rare 9,9’-bianthryl antibiotic first isolated from a strain of Streptomyces pseudovenezuelae by Omura and colleagues at the Kitasato Institute, Japan, in 1978. Setomimycin is active against Gram positive bacteria, including mycobacteria, and has antitumor activity both in vitro and in vivo. Limited access has restricted further research on this metabolite.

Uses

Setomimycin is an antibiotic that is active against Gram positive bacteria, including mycobacteria.

in vivo

Setomimycin (20 mg/kg; i.p.; alternate days for two weeks) shows antitumor activity in mice[2].
Pharmacokinetic Parameters of Setomimycin in female BALB/c mice[2].

Pharmacokinetic parametersValue
Cmax (ng/ml)694 ± 62
Tmax (h)0.3 ± 0.1
T1/2 (h)2.3 ± 0.5
AUC0-t (ng.h/mL)2613 ± 111
AUC0-α (ng.h/mL)2734 ± 108
Vd (L/Kg)24 ± 4
Cl (L/h/Kg)7.4 ± 0.3
Female BALB/c mice, 20 mg/kg ip (1 % DMSO +30 % PEG-200 + 2 % Tween 80 + q.s. water (v/v))[2]
Animal Model:6 weeks, 25-30 g, female BALB/c mice (4T1 cells)[2]
Dosage:20 mg/kg
Administration:I.p.; every other day for two weeks
Result:Decreased primary tumor weight (76%) and volume (90.5%).

1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione Suppliers

China 27 United Kingdom 2 United States 4 Global 33
Shanghai EFE Biological Technology Co., Ltd.
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TargetMol Chemicals Inc.
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69431-87-4, 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dioneRelated Search:

Clindamycin Azithromycin 9,9'-Bianthracene Oxytetracycline hydrochloride Oxytetracycline

  • 1,1'-Diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl[9,9'-bianthracene]-4,4'(1H,1'H)-dione
  • A-39183B
  • Antibiotic A-39183B
  • Setomimycin
  • SetoMiMycin [SetoMiMicin]
  • AM 2947
  • AM2947
  • AM-2947
  • [9,9'-Bianthracene]-4,4'(1H,1'H)-dione, 1,1'-diacetyl-2,3-dihydro-2,5,5',10,10'-pentahydroxy-2,2'-dimethyl- (9CI)
  • 69431-87-4