5-CARBOXYBENZIMIDAZOLONE METHYL ESTER

Product Name: 5-CARBOXYBENZIMIDAZOLONE METHYL ESTER
CAS No.: 106429-57-6
Chemical Name: 5-CARBOXYBENZIMIDAZOLONE METHYL ESTER
Synonyms: 5- CARBOXYBENZIMIDAZOLONE;5-CARBOXYBENZIMIDAZOLONE METHYL ESTER;Methyl 2-Oxo-2,3-dihydrobenzimidazole-5-carboxylate;methyl 2-hydroxy-1H-benzo[d]imidazole-5-carboxylate;Methyl 2,3-dihydro-2-oxo-1H-benzimidazole-5-carboxylate;Methyl 2-oxo-1,3-dihydro-1,3-benzodiazole-5-carboxylate;methyl 2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylate;methyl 2-oxo-2,3-dihydro-1H-1,3-benzimidazole-5-carboxylate;Methyl 2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-5-carboxylate;2-Oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid methyl ester
CBNumber: CB1215104
Molecular Formula: C9H8N2O3
Formula Weight: 192.17
MOL File: 106429-57-6.mol

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5-CARBOXYBENZIMIDAZOLONE METHYL ESTER Property

Melting point:: 312-313°
Boiling point:: 221.2±19.0 °C(Predicted)
Density: 1.325±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 11.54±0.30(Predicted)
Appearance: Light brown to gray Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 046773
Product name: Methyl 2-oxo-2,3-dihydro-1H-1,3-benzimidazole-5-carboxylate
Purity: >95%
Packaging: 500mg
Price: $77
Updated: 2021/12/16

Matrix Scientific

Product number: 046773
Product name: Methyl 2-oxo-2,3-dihydro-1H-1,3-benzimidazole-5-carboxylate
Purity: >95%
Packaging: 1g
Price: $119
Updated: 2021/12/16

AK Scientific

Product number: X8804
Product name: Methyl2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate
Packaging: 1g
Price: $212
Updated: 2021/12/16

BroadPharm

Product number: BP-20127
Product name: methyl2-hydroxy-3H-benzo[d]imidazole-5-carboxylate
Purity: 96%
Packaging: 500mg
Price: $320
Updated: 2021/12/16

Matrix Scientific

Product number: 046773
Product name: Methyl 2-oxo-2,3-dihydro-1H-1,3-benzimidazole-5-carboxylate
Purity: >95%
Packaging: 5g
Price: $440
Updated: 2021/12/16

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5-CARBOXYBENZIMIDAZOLONE METHYL ESTER Chemical Properties,Usage,Production

Synthesis

36692-49-6

530-62-1

106429-57-6

Methyl 3,4-diaminobenzoate (5.00 g, 30.1 mmol) was dissolved in THF (40 mL) at 0 °C, followed by the addition of N,N'-carbonyldiimidazole (7.32 g, 45.1 mmol). The reaction mixture was stirred at 0 °C for 16 h and gradually warmed up to 23 °C. Upon completion of the reaction, 1M HCl aqueous solution (50 mL) was slowly added followed by water (70 mL) at 0 °C and stirring was continued for 1 hour. The resulting precipitate was collected by filtration and dried under reduced pressure for 18 h to afford methyl 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylate (5.45 g, 94% yield), and the product could be used for subsequent reactions without further purification. Mass spectrum (ESI/CI): calculated value C9H8N2O3, 192.1; measured value m/z 193.1 [M+H]+. 1H NMR (400 MHz, CDCl3) δ: 11.01 (s, 1H), 10.84 (s, 1H), 7.63 (dd, J=8.2,1.6Hz, 1H), 7.47 (s, 1H). 7.02 (d, J=8.2Hz, 1H), 3.82 (s, 3H).

References

[1] Patent: WO2009/134750, 2009, A1. Location in patent: Page/Page column 139
[2] Journal of Medicinal Chemistry, 2006, vol. 49, # 12, p. 3719 - 3742
[3] Patent: US2010/249124, 2010, A1. Location in patent: Page/Page column 62
[4] Cell Chemical Biology, 2018, vol. 25, # 6, p. 677 - 12,690

5-CARBOXYBENZIMIDAZOLONE METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CARBOXYBENZIMIDAZOLONE METHYL ESTER Suppliers

China 65 Europe 1 India 2 United Kingdom 2 United States 9 Global 79

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View Lastest Price from 5-CARBOXYBENZIMIDAZOLONE METHYL ESTER manufacturers

Career Henan Chemical Co

Product: 5-CARBOXYBENZIMIDAZOLONE METHYL ESTER 106429-57-6
Price: US $0.01/KG
Min. Order: 1KG
Purity: 98%; 99%
Supply Ability: 500g； 1kg; 25kg
Release date: 2020-01-10

Career Henan Chemical Co

Product: 5-CARBOXYBENZIMIDAZOLONE METHYL ESTER 106429-57-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: 1ton
Release date: 2019-12-18

106429-57-6, 5-CARBOXYBENZIMIDAZOLONE METHYL ESTERRelated Search:

METHYL 2-OXO-1-PIPERIDIN-4-YL-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBOXYLATE 2-OXO-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBOXYLIC ACID 5-CARBOXYBENZIMIDAZOLONE METHYL ESTER ethyl 1-ethyl-2-oxo-2,3-dihydro-1H-benzimidazole-5-carboxylate METHYL 2-OXO-3-PIPERIDIN-4-YL-2,3-DIHYDRO-1H-BENZOIMIDAZOLE-5-CARBOXYLATE

5-CARBOXYBENZIMIDAZOLONE METHYL ESTER

1H-Benzimidazole-5-carboxylicacid,2,3-dihydro-2-oxo-,methylester(9CI)

methyl 2-oxo-2,3-dihydro-1H-1,3-benzimidazole-5-carboxylate

1H-Benzimidazole-5-carboxylic acid, 2,3-dihydro-2-oxo-, methyl ester

2-Oxo-2,3-dihydro-1H-benzoimidazole-5-carboxylic acid methyl ester

Methyl 2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-5-carboxylate

methyl 2-oxo-2,3-dihydro-1H-1,3-benzodiazole-5-carboxylate

Methyl 2-oxo-1,3-dihydro-1,3-benzodiazole-5-carboxylate

Methyl 2-Oxo-2,3-dihydrobenzimidazole-5-carboxylate

Methyl 2,3-dihydro-2-oxo-1H-benzimidazole-5-carboxylate

5- CARBOXYBENZIMIDAZOLONE

methyl 2-hydroxy-1H-benzo[d]imidazole-5-carboxylate

106429-57-6

BENZIMIDAZOLE