2-(4-Formylphenyl)acetic acid
- Product Name
- 2-(4-Formylphenyl)acetic acid
- CAS No.
- 34841-47-9
- Chemical Name
- 2-(4-Formylphenyl)acetic acid
- Synonyms
- 4-Formylbenzeneacetic acid;14-Formylbenzeneacetic acid;4-carboxymethyl benzaldehyde;Benzeneacetic acid, 4-forMyl-;2-(4-Formylphenyl)acetic acid
- CBNumber
- CB12199394
- Molecular Formula
- C9H8O3
- Formula Weight
- 164.16
- MOL File
- 34841-47-9.mol
2-(4-Formylphenyl)acetic acid Property
- Melting point:
- 131 °C
- Boiling point:
- 349.2±17.0 °C(Predicted)
- Density
- 1.277±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.06±0.10(Predicted)
- InChI
- InChI=1S/C9H8O3/c10-6-8-3-1-7(2-4-8)5-9(11)12/h1-4,6H,5H2,(H,11,12)
- InChIKey
- AGPZPJHWVWZCMG-UHFFFAOYSA-N
- SMILES
- C1(CC(O)=O)=CC=C(C=O)C=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F754680
- Product name
- 2-(4-Formylphenyl)aceticAcid
- Packaging
- 100mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- 4244AB
- Product name
- 2-(4-Formylphenyl)aceticacid
- Packaging
- 1g
- Price
- $593
- Updated
- 2021/12/16
- Product number
- 34841479
- Product name
- 2-(4-Formylphenyl)aceticacid
- Packaging
- 1g
- Price
- $311.13
- Updated
- 2021/12/16
- Product number
- CD12080614
- Product name
- 2-(4-Formylphenyl)aceticacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $382
- Updated
- 2021/12/16
2-(4-Formylphenyl)acetic acid Chemical Properties,Usage,Production
Synthesis
13737-36-5
34841-47-9
The general procedure for the synthesis of 2-(4-formylphenyl)acetic acid from 4-(bromomethyl)phenylacetic acid was as follows: 1. Preparation of Intermediate 4: To a mixed solution of 2-[4-(bromomethyl)phenyl]acetic acid (770 mg, 3.36 mmol) in ethanol (6 mL) and water (6 mL) was added hexamethylenetetramine (1.26 g, 9.0 mmol). 2. The reaction mixture was heated to reflux for 4 hours. 3. Concentrated hydrochloric acid (1.5 mL) was slowly added to the mixture under reflux. 4. Continue heating and refluxing for 30 minutes, then cool to room temperature. 5. Water (20 mL) and dichloromethane (20 mL) were added, and the organic phase was separated and filtered through hydrophobic filter paper. 6. The solvent was removed by vacuum to afford the title compound 2-(4-formylphenyl)acetic acid as an off-white solid (479 mg, 87% yield). 7. The product was analyzed by 1H NMR. 7. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 10.01 (s, 1H), 7.86 (d, J = 7.9 Hz, 2H), 7.47 (d, J = 7.9 Hz, 2H), 3.75 (s, 2H).
References
[1] Patent: WO2014/86849, 2014, A1. Location in patent: Page/Page column 81; 82
[2] Patent: US2014/155428, 2014, A1. Location in patent: Paragraph 0469 - 0471
[3] Patent: WO2015/185128, 2015, A1. Location in patent: Page/Page column 46; 47
[4] Organic Letters, 2008, vol. 10, # 20, p. 4589 - 4592
[5] Patent: WO2014/202580, 2014, A1. Location in patent: Page/Page column 80
2-(4-Formylphenyl)acetic acid Preparation Products And Raw materials
Raw materials
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View Lastest Price from 2-(4-Formylphenyl)acetic acid manufacturers
- Product
- 2-(4-Formylphenyl)acetic acid 34841-47-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-25
- Product
- 2-(4-Formylphenyl)acetic acid 34841-47-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-07-31
- Product
- 2-(4-Formylphenyl)acetic acid 34841-47-9
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kg/month
- Release date
- 2020-01-06