GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL

Product Name: GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL
CAS No.: 479065-85-5
Chemical Name: GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL
Synonyms: ORN8, UROTENSIN II, HUMAN;GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL;L-Valine, L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-, cyclic (5→10)-disulfide (9CI)
CBNumber: CB1224201
Molecular Formula: C63H83N13O18S2
Formula Weight: 1374.54
MOL File: Mol file

More

Less

GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL Property

storage temp.: Desiccate at -20°C
solubility: Soluble to 100 mM in DMSO and to 100 mM in ethanol
form: solid
color: White lyophilised
Sequence: Glu-Thr-Pro-Asp-Cys-Phe-Trp-{Orn}-Tyr-Cys-Val (Disulfide bridge:Cys5-Cys10)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL Chemical Properties,Usage,Production

Description

Inhibitor of glycogen synthase kinase-3 (GSK-3); derived from FRAT1, the mammalian version of GSK-3-binding protein. Binds to GSK-3, inhibiting its interaction with axin, and also blocks GSK-3-catalyzed phosphorylation of axin and β-catenin. Does not affect GSK-3-mediated phosphorylation of glycogen synthase or eIF2B.

Uses

[Orn8]-Urotensin II (human), a peptide analog of urotensin II, is a UT receptor agonist. [Orn8]-Urotensin II (human) increases intracellular calcium levels in HEK293[1].

References

[1] Camarda V, et al. Urantide mimics urotensin-II induced calcium release in cells expressing recombinant UT receptors. Eur J Pharmacol. 2004 Sep 13;498(1-3):83-6. DOI:10.1016/j.ejphar.2004.07.089
[2] Camarda V, et al. A new ligand for the urotensin II receptor. Br J Pharmacol. 2002 Oct;137(3):311-4. DOI:10.1038/sj.bjp.0704895

GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL Suppliers

China 28 United States 3 Global 31

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Nanjing Leon Biological Technology Co., Ltd.

Tel: 17705183659
Fax: 84523390
Email: sales@njleonbiotech.com
Country: China
ProdList: 5501
Advantage: 55

Nanjing Peptide Biotech Ltd.

Tel: 025-58361106-805 15951641583
Fax: 025-58361106-806
Email: zhao.xu@njpeptide.com
Country: China
ProdList: 9979
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4802
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7408
Advantage: 58

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 0571-88211921
Email: sales1@gotopbio.com
Country: CHINA
ProdList: 2609
Advantage: 58

Career Henan Chemica Co

Tel: +86-0371-86658258 +8613203830695
Fax: 0371-86658258
Email: laboratory@coreychem.com
Country: China
ProdList: 30229
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 15397062932
Email: sales1@gotopbio.com
Country: China
ProdList: 3059
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 29668
Advantage: 58

479065-85-5, GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VALRelated Search:

UROTENSIN II (HUMAN) UROTENSIN I

GLU-THR-PRO-ASP-CYS-PHE-TRP-ORN-TYR-CYS-VAL

ORN8, UROTENSIN II, HUMAN

L-Valine, L-α-glutamyl-L-threonyl-L-prolyl-L-α-aspartyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-L-ornithyl-L-tyrosyl-L-cysteinyl-, cyclic (5→10)-disulfide (9CI)

479065-85-5

C63H83N13O18S2