5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID

Product Name: 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
CAS No.: 118414-59-8
Chemical Name: 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID
Synonyms: NTZDPA;5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylic acid;5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID;1H-Indole-2-carboxylic acid, 5-chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-
CBNumber: CB1224807
Molecular Formula: C22H15Cl2NO2S
Formula Weight: 428.33
MOL File: 118414-59-8.mol

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5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Property

storage temp.: Store at +4°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
color: white to beige

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Safety

RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0616
Product name: nTZDpa
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $128
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0616
Product name: nTZDpa
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $484
Updated: 2023/06/20

TRC

Product number: C365800
Product name: 5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylicAcid
Packaging: 50mg
Price: $635
Updated: 2021/12/16

Usbiological

Product number: 256070
Product name: nTZDpa
Packaging: 10mg
Price: $432
Updated: 2021/12/16

Chemenu

Product number: CM267890
Product name: 5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylicacid
Purity: 95%
Packaging: 1g
Price: $790
Updated: 2021/12/16

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5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

nTZDpa is a PPARγ agonist, with pharmaceutical applications such as anti-diabetic drugs.

Biological Activity

Potent, selective non-thiazolidinedione PPAR γ partial agonist (EC 50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC 50 ~ 285 nM). Displays no activity at PPAR α or PPAR δ receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR γ agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .

storage

Store at +4°C

5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID Suppliers

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118414-59-8, 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACIDRelated Search:

5-CHLORO-3-(PHENYLTHIO)-INDOLE 5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID 1-PHENYLMETHYL-1H-INDOLE-2-METHANOL

NTZDPA

5-CHLORO-1-[(4-CHLOROPHENYL)METHYL]-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID

5-Chloro-1-(4-chlorobenzyl)-3-(phenylthio)-1H-indole-2-carboxylic acid

1H-Indole-2-carboxylic acid, 5-chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-

118414-59-8

Intracellular receptor

Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals