7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
- Product Name
- 7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
- CAS No.
- 99365-69-2
- Chemical Name
- 7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
- Synonyms
- 7-NITRO-1,2,3,4-TETRAHYDROISOQUINOLINE HCL;1,2,3,4-tetrahydro-7-nitroisoquinoline hydrochloride;7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE;7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride, 97+%;7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride (1:1);Isoquinoline,1,2,3,4-tetrahydro-7-nitro-, hydrochloride (1:1)
- CBNumber
- CB1227282
- Molecular Formula
- C9H11ClN2O2
- Formula Weight
- 214.65
- MOL File
- 99365-69-2.mol
7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Property
- Melting point:
- 214-216 °C(Solv: methanol (67-56-1))
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light brown to gray Solid
- CAS DataBase Reference
- 99365-69-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- N900680
- Product name
- 7-Nitro-1,2,3,4-tetrahydroisoquinolineHydrochloride
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- AK-31139
- Product name
- 7-Nitro-1,2,3,4-tetrahydroisoquinolinehydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $9
- Updated
- 2021/12/16
- Product number
- CS-W003395
- Product name
- 7-Nitro-1,2,3,4-tetrahydroisoquinolinehydrochloride
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $33
- Updated
- 2021/12/16
- Product number
- 073763
- Product name
- 7-Nitro-1,2,3,4-tetrahydroisoquinolinehydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-W003395
- Product name
- 7-Nitro-1,2,3,4-tetrahydroisoquinolinehydrochloride
- Purity
- >97.0%
- Packaging
- 5g
- Price
- $126
- Updated
- 2021/12/16
7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Chemical Properties,Usage,Production
Synthesis
91-21-4
99365-69-2
7-Nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride was synthesized as follows: 1,2,3,4-tetrahydroisoquinoline (13.3 g, 0.1 mol) was dissolved in concentrated sulfuric acid (50 mL) and cooled to 0-5°C. At this temperature, potassium nitrate (11.12 g, 1.1 mol) was added in batches to ensure that the temperature of the reaction did not exceed 5°C. After addition, the reaction was allowed to proceed. After addition, the mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was slowly poured into ice water. The pH was adjusted to alkaline with ammonium hydroxide solution and subsequently extracted with dichloromethane (CH2Cl2). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated to dryness under reduced pressure. The crude product was dissolved in ethanol (100 mL) and 2.8 M ethanol solution of hydrogen chloride (40 mL) was added. The precipitated solid was collected by filtration and recrystallized from methanol to give the white solid product 7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride (10.30 g, 48% yield). The melting point of the product was 268-270°C. IR (KBr, cm-1): 2944, 2764, 1589, 1523, 1429, 1345, 1090. 1H NMR (300 MHz, DMSO-d6) δ ppm: 3.13 (t, J = 6.15 Hz, 2H), 3.35 (t, J = 6.22 Hz, 2H), 4.35 (s, 2H). 4.35 (s, 2H), 7.50 (d, J = 8.49 Hz, 1H), 8.08 (dd, J = 8.49, 2.49 Hz, 1H), 8.19 (d, J = 2.34 Hz, 1H), 9.96 (s, 2H).
References
[1] Patent: US2010/234340, 2010, A1. Location in patent: Page/Page column 21
[2] Patent: US2006/40978, 2006, A1. Location in patent: Page/Page column 9
[3] Chemistry - A European Journal, 2009, vol. 15, # 4, p. 885 - 900
[4] Patent: EP3363803, 2018, A1. Location in patent: Paragraph 0153
[5] Patent: EP3401315, 2018, A1. Location in patent: Paragraph 0148; 0149
7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- info@activate-scientific.com
- Country
- Germany
- ProdList
- 2856
- Advantage
- 61
View Lastest Price from 7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE manufacturers
- Product
- 7-NITRO-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE 99365-69-2
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-02-01