5-NITROPHTHALAZINE
- Product Name
- 5-NITROPHTHALAZINE
- CAS No.
- 89898-86-2
- Chemical Name
- 5-NITROPHTHALAZINE
- Synonyms
- 5-NITROPHTHALAZINE;Phthalazine, 5-nitro-
- CBNumber
- CB1230756
- Molecular Formula
- C8H5N3O2
- Formula Weight
- 175.14
- MOL File
- 89898-86-2.mol
5-NITROPHTHALAZINE Property
- Melting point:
- 187-188 °C
- Boiling point:
- 421.5±20.0 °C(Predicted)
- Density
- 1.437±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 0.42±0.30(Predicted)
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- N497123
- Product name
- 5-Nitrophthalazine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- N497123
- Product name
- 5-Nitrophthalazine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 071916
- Product name
- 5-Nitrophthalazine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $416
- Updated
- 2021/12/16
- Product number
- W9268
- Product name
- 5-Nitrophthalazine
- Packaging
- 1g
- Price
- $611
- Updated
- 2021/12/16
- Product number
- CHM0166471
- Product name
- 5-NITROPHTHALAZINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1034.88
- Updated
- 2021/12/16
5-NITROPHTHALAZINE Chemical Properties,Usage,Production
Uses
5-nitrophthalazine is a useful chemical in the formation of a photothermographic material and used for image forming.
Synthesis
253-52-1
89898-86-2
The general procedure for the synthesis of 5-nitrophthalazine from 2,3-diazanaphthalene was as follows: 3.0 g (23.3 mmol) of 2,3-diazanaphthalene was dissolved in 20 mL of concentrated sulfuric acid and heated up to 100°C. The reaction was carried out in the following manner. Within 1 hour, 18.8 g (186 mmol) of potassium nitrate was added to the reaction system in batches. The reaction temperature was maintained at 100 °C for 72 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature, slowly poured into ice water and neutralized to neutrality with ammonium hydroxide solution, at which time a yellow-brown precipitate was generated. The precipitate was collected by filtration and dried to give 2.3 g (56% yield) of 5-nitrophthalazine intermediate as a light yellow solid. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100.17 MHz, DMSO-d6) as follows: 1H NMR δ: 10.2 (s, 1H), 9.98 (s, 1H), 8.84 (d, J = 7.4 Hz, 1H), 8.59 (d, J = 7.6 Hz. 1H), 8.20 (dd, J = 7.4,14.9 Hz, 1H); 13C NMR δ: 152.1,146.3,141.0,133.2,131.8,130.0,127.4,118.7.
References
[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 9, p. 3938 - 3942
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 478 - 487
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 8, p. 1329 - 1340
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 3, p. 744 - 752
[5] Patent: US2006/116368, 2006, A1. Location in patent: Page/Page column 35
5-NITROPHTHALAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-NITROPHTHALAZINE Suppliers
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