2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate

Product Name: 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate
CAS No.: 89604-92-2
Chemical Name: 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate
Synonyms: BPTA;(Z)-TERT-BUTYL 2-(1-(2-AMINOTHIAZOL-4-YL)-2-(BENZO[D]THIAZOL-2-YLTHIO)-2-OXOETHYLIDENEAMINOOXY)-2-METHYLPROPANOATE;tert-butyl (Z)-2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)-2-methylpropanoate;TAEM CAS;Ceftazidimum;-2-oxoethylidene);-2-methylpropanoate;Aztreonam Side Chain;-2-(benzo[d]thiazol-2-ylthio);2-(2-Amino-4-thiazole)-2-(tert
CBNumber: CB1232053
Molecular Formula: C20H22N4O4S3
Formula Weight: 478.61
MOL File: 89604-92-2.mol

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2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate Property

Melting point:: 138-140°C
Boiling point:: 621.6±61.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: Chloroform, Methanol
form: Solid
pka: 0.83±0.10(Predicted)
color: Pale Yellow
InChI: InChI=1S/C20H22N4O4S3/c1-19(2,3)27-16(26)20(4,5)28-24-14(12-10-29-17(21)22-12)15(25)31-18-23-11-8-6-7-9-13(11)30-18/h6-10H,1-5H3,(H2,21,22)/b24-14-
InChIKey: RCZJVHXVCSKDKB-OYKKKHCWSA-N
SMILES: C(OC(C)(C)C)(=O)C(O/N=C(/C1=CSC(N)=N1)\C(SC1=NC2=CC=CC=C2S1)=O)(C)C
CAS DataBase Reference: 89604-92-2(CAS DataBase Reference)

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Safety

Risk Statements: 53
Safety Statements: 61

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M252610
Product name: 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl)isopropoxyiminoacetate
Packaging: 5g
Price: $485
Updated: 2021/12/16

AK Scientific

Product number: J99911
Product name: (Z)-tert-Butyl2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)-2-methylpropanoate
Packaging: 1g
Price: $49
Updated: 2021/12/16

Matrix Scientific

Product number: 076087
Product name: (Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)-2-methylpropanoate
Purity: 95+%
Packaging: 5g
Price: $200
Updated: 2021/12/16

Matrix Scientific

Product number: 076087
Product name: (Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)-2-methylpropanoate
Purity: 95+%
Packaging: 10g
Price: $286
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000324
Product name: BENZOTHIAZOL-2-YL-(Z)-2-(TERT-BUTOXYCARBONYLPROP-2-OXYIMINO)-(2-AMINOTHIAZOL-4-YL)THIOACETATE
Purity: 95.00%
Packaging: 1G
Price: $704.55
Updated: 2021/12/16

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2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

An intermediate for the preparation of cephalosporin derivatives.

Synthesis

120-78-5

86299-47-0

89604-92-2

Synthesis of (Z)-2-(((1-(2-aminothiazol-4-yl)-2-((1-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetic acid from dibenzothiazole disulfide and (Z)-2-((2-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy) The general procedure for tert-butyl -2-methylpropanoate was as follows: 35 g of (Z)-2-(2-aminothiazol-4-yl)-2-(((1-(tert-butoxy)-2-methyl-1-oxopropan-2- yl)oxy)imino)acetic acid and 48 g of dibenzothiazole disulfide were added to a solvent mixture of dichloromethane and acetonitrile at 21 °C. (the total mass of the solvent mixture was 250 g, the density of 1.0 g/cm3). After stirring for 10 minutes, 1.0 mL of pyridine was added. At 22°C, 8.0 mL of triethylamine was slowly added. After addition, the reaction temperature was raised to 30°C and kept at this temperature for 50 minutes. Subsequently, the reaction mixture was cooled to 21 °C, and 28 mL of triethyl phosphite was slowly added dropwise at this temperature, with the dropwise addition process controlled to be completed within 2.5 hours. After the dropwise addition was completed, the reaction solution was continued at 21±1 °C for 3.0 hours. After that, the reaction mixture was cooled to 3°C and kept at this temperature for 30 minutes. Upon completion of the reaction, filtration was carried out, the solid product was collected and dried at 60 °C to afford the target product (Z)-tert-butyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylsulfanyl)-2-oxoethylidene)amino)oxy)-2-methylpropanoate in 92.6% yield and 99.3% purity.

References

[1] Patent: CN106699683, 2017, A. Location in patent: Paragraph 0028-0033

2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate Preparation Products And Raw materials

Raw materials

Triethylamine

Preparation Products

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2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate Suppliers

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View Lastest Price from 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate 89604-92-2
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%+
Supply Ability: 300 MT
Release date: 2020-05-23

Career Henan Chemical Co

Product: 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate 89604-92-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-08-07

89604-92-2, 2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetateRelated Search:

Cemandil sodium salt Propionic acid Betaine Cefetamet pivoxyl CeftazidiMe Glycine Ceftazidime ALTRENOGEST Cefetamet pivoxil hydrochloride Cefetamet hydrochloride Cefpodoxime proxetil TAEM (Z)-2-Amino-alpha-[1-(tert-butoxycarbonyl)]-1-methylethoxyimino-4-thiazolacetic acid 1-[[(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinium chloride monohydrochloride 7(R)-amino-3-(1-pyridiniomethyl)-3-cephem-4-carboxylic acid chloride monohydrochloride DI-TERT-BUTYL ETHER Methylthio acetaldoxime 2-(ISOPROPYLIDENEAMINOOXY)PROPIONIC ACID

2-MERCAPTOBENZOTHIAZOLYL-(Z)(2-AMINOTHIAZOLE-4YL)-2-(TERT-BUTOXYCARBONYL)ISOPROPOXYIMINO ACETATE

S-2-BENZOTHIAZOYL-(Z)-2-(1-TERT-BUTOXYCARBONYL-1-METHYLETHOXYIMINO)-2-(AMINOTHIAZOL-4-YL)ACETATE

S-2-BENZOTHIAZOLYL-(Z)-2-(TERT-BUTOXYCARBONYL-ISOPROPOXYIMINO)THIOACETATE BENZOTHIAZOLE ESTER

S-2-BENZOTHIAZOLYL (Z)-2-(2-AMINOTHIAZOL-4-YL)-2-(1-T-BUTOXYCARBONYL-1-METHYL)ETHOXYIMINOTHIOACETATE

S-2-BENZOTHIAZOLYL-(2)-2-(1-TERBATOXYCANBONYL-1-METHYLETHOXYIMINO)-4-THIAZOLE ACETATE

(Z)-TERT-BUTYL 2-(1-(2-AMINOTHIAZOL-4-YL)-2-(BENZO[D]THIAZOL-2-YLTHIO)-2-OXOETHYLIDENEAMINOOXY)-2-METHYLPROPANOATE

S-2-benzothiazoyl-(Z)-2-(1-ter-butoxycanbonyl-1-methylethoxyimino)-4-thiazoleacetate

S-2-Benzothiazoyl-(Z)-2-(ter-butoxycarbonyl-isopropoxyimino)-4-thiazoleacetate(TAEM)

2-mercaptobenzoly-α-(2-aminothiazol-4-yl)-alpha-[(tert-butoxycarbonyl)-Isopropoxyimino] acetate

Benzothiazol-2-yl-(Z)-2-(ter-butoxycarbonylprop-2-oxyimino)-(2-aminothiazol-4-yl)thioacetate

Ceftazidimum

2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tertbutoxycarbonyl) isopropoxyimi

-2-(benzo[d]thiazol-2-ylthio)

-2-methylpropanoate

-2-oxoethylidene)

-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)

(Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino

(Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)-2-methylpropanoate

S-2-BENZOTHIAOYL-(Z)-2-(TERT-BUTOXYCARBONYLISOPROPOXYIMINO)-4-THIAZOLEACETATE

2-(2-Amino-4-thiazole)-2-(tert

2-Mercaptobenzothiazolyl-(Z)-2-(2-aminothiazole-4-yl)[(Tert-Butoxycarbonyl)-Isopropoxyimino] Acetate

2-MERCAPTOBENZOLYL-ALPHA-(2-AMINOTHIAZOL-4-YL)-ALPHA-[(TERT-BUTOXYCARBONYL)ISOPROPOXYIMINO]ACETATE

TAEM CAS

2-MERCAPTOBENZOLYL-Z-(2-AMINOTHIAZOL-4-YL)-2-[(TERT-BUTOXYCARBONYL)ISO-PROPOXYAMINO]ACETATE

Benzothiazol-2-yl-(Z)-2-(tert-Butoxycarbonylprop-2-Oxyimino)-(2-Aminothiazol-4-yl)Thioacetate

2-Mercaptobenzolyl-|α-(2-Aminothiazol-4-yl)-|α-[(tert-Butoxycarbonyl)-Isopropoxyimino]Acetate (TAEM)

BENZOTHIAZOL-2-YL-(Z)-2-(TERT-BUTOXYCARBONYLPROP-2-OXYIMINO)-2-(2-AMINOTHIAZOL-4-YL)THI-OACETATE

benzothiazolyl[2-(2-tert-butoxycarbonylprop-2-oxyimino)-2-(2-aminothiazol-4-yl)]thio acetate

2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate

Benzothiazolyl [2-(2-tert-butoxy-carbonylprop-2-oxdyimino)-2-(4-amino-thiazol-4-yl) thio acetate

BPTA

Propanoic acid (Z)-2-[[[1-(2-amino-4-thiazolyl)-2-(2-benzothiazolylthio)-2-oxoethylidene]amino]oxy]-2-methyl-1,1-dimethylethyl ester

2-MERCAPTOBENZOLYL-A-(2-AMINOTHIAZOL-4-YL)-A-[(TERTBUTOXYCARBONYL)ISOPROPOXYIMINO]ACETATE

BENZOTHIAZOL-2-YL-(Z)-2-(TERT-BUTOXYCARBONYLPROP-2-OXYIMINO)-(2-AMINOTHIAZOL-4-YL)THIOACETAE

S-2-benzothiazolyl-(2)-2-(1-terbatoxycanbonyl-1-methylethoxyimino)-4-thiazole acetate (TAEM)

2-Mercaptobenzolyl-α-(2-AMinothiazol-4-yl)-α-[(t-Butoxycarbonyl)-IsopropoxyiMino] Acetate

(Z)-tert-Butyl 2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)ox

2-Mercaptobenzothiazolyl-(Z)-(2-aMinothiazol-4-yl)-2-(tertbutoxycarbonyl) isopro

2-[[(Z)-[1-(2-AMino-4-thiazolyl)-2-(2-benzothiazolylthio)-2-oxoethylidene]aMino]oxy]-2-Methylpropanoic Acid 1,1-DiMethylethyl Ester

(E)-tert-butyl 2-(1-(2-aMinothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylideneaMinooxy)-2-Methylpropanoate

2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-

benzothiazolylthio)-2-oxoethylidene]amino]oxy]-2-

methyl-1,1-dimethylethyl ester, (Z)-

Propanoic acid, 2-[[[1-(2-amino-4-thiazolyl)-2-(2-

2-(2-Amino-4-thiazolyl)-2-(tertbutoxycarbonylisopropoxyimino)acetic acid thiobenzothiazole ester

(2-Amino-thiazol-4-yl)-(1,1-dimethyl-2-oxo-ethoxyimino)-thioaceticacidO-benzothiazol-2-ylest

Ceftazidime Active Ester Side Chain

tert-Butyl (Z)-2-[[[1-(2-Amino-4-thiazolyl)-2-[benzo[d]thiazol-2-ylthio]-2-oxoethylidene]amino]oxy]-2-methylpropionate

2-[[1-(2-amino-4-thiazolyl)-2-(1,3-benzothiazol-2-ylthio)-2-oxoethylidene]amino]oxy-2-methylpropanoic acid tert-butyl ester

tert-butyl (Z)-2-(((1-(2-aminothiazol-4-yl)-2-(benzo[d]thiazol-2-ylthio)-2-oxoethylidene)amino)oxy)-2-methylpropanoate

Propanoic acid, 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-(2-benzothiazolylthio)-2-oxoethylidene]amino]oxy]-2-methyl-, 1,1-dimethylethyl ester

TAEM 2-Mercaptobenzothiazolyl-(Z)-2-(2-Aminothiazole-4-yl)-[(Tert-Butoxycarbonyl)-Isopropoxyimino] Acetate

2-Mercaptobenzothiazolyl-(Z)-(2-aminothiazol-4-yl)-2-(tert-butoxycarbonyl) isopropoxyiminoacetate USP/EP/BP

Ceftazidime Related Compound 3

Ceftazidime side chain acid active ester

Benzenesulfonicacid,4-methyl-,6-methylpropylester

Aztreonam Side Chain

1,1-Dimethylethyl 2-[[(Z)-[1-(2-amino-4-thiazolyl)-2-(2-benzothiazolylthio)-2-oxoethylidene]amino]oxy]-2-methylpropanoate