2,4-DIFLUOROPHENYLACETONE

2,4-DIFLUOROPHENYLACETONE Property

Boiling point:

201.3±25.0 °C(Predicted)

Density 

1.179±0.06 g/cm3(Predicted)

refractive index 

1.477-1.479

storage temp. 

Sealed in dry,Room Temperature

form 

Liquid

color 

Clear yellow

CAS DataBase Reference

274682-91-6

Safety

Safety Statements 

24/25

HS Code 

29147000

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

2,4-DIFLUOROPHENYLACETONE Chemical Properties,Usage,Production

Chemical Properties

Clear yellow liquid

Synthesis

Example 6 Synthesis of 1-(2,4-difluorophenyl)propan-2-one Under stirring and ice bath cooling conditions, 132.0 g (1.32 mol) of concentrated sulfuric acid was slowly added to 375 ml of water for dilution, keeping the reaction temperature at 10-15 °C. Subsequently, 0.60 mol of 2,4-difluoroaniline was added to the diluted sulfuric acid solution to form a suspension. 104.6 g (0.606 mol) of 40% sodium nitrite aqueous solution was slowly added dropwise to the suspension at 0-3 °C for 45 min. In another reactor, a mixture comprising 6.0 g of copper sulfate pentahydrate, 180 ml of water, 0.9 g of concentrated sulfuric acid and 91.2 g (0.90 mol) of isopropyl acetate was prepared. The diazonium salt solution prepared above and 50.4 g of 20% aqueous sodium sulfite solution were added slowly into the mixture simultaneously, the reaction temperature was maintained at 10-15 °C during the addition process, and the dropwise addition time was controlled to be within 2 hours. After addition, the reaction mixture was continued to be stirred for 1 hour. Upon completion of the reaction, two extractions were carried out with toluene and the organic layers were combined. The organic layer was washed with dilute sodium bicarbonate solution to neutralize the acid. Subsequently, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was subjected to decompression distillation at 75-80 °C/5 mbar to afford 85.8 g of light yellow liquid 1-(2,4-difluorophenyl)propan-2-one in 82.9% yield.

References

[1] Patent: US6664422, 2003, B1. Location in patent: Page column 9