2-(PROPYL-2,2-D2)PENTANOIC-4,4-D2 ACID
- Product Name
- 2-(PROPYL-2,2-D2)PENTANOIC-4,4-D2 ACID
- CAS No.
- 345909-03-7
- Chemical Name
- 2-(PROPYL-2,2-D2)PENTANOIC-4,4-D2 ACID
- Synonyms
- Valproic-d4 Acid;Valproic acid (4,4,4',4'-D4);Valproic acid (4,4,4′,4′-D?, 98%);2-(Propyl-2,2-d2)pentanoic--d2 Acid;2-(PROPYL-2,2-D2)PENTANOIC-4,4-D2 ACID
- CBNumber
- CB1235726
- Molecular Formula
- C8H16O2
- Formula Weight
- 144.21
- MOL File
- 345909-03-7.mol
N-Bromosuccinimide Price
- Product number
- V947836
- Product name
- Valproic-d4Acid
- Packaging
- 11mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- RDL0007289
- Product name
- PENTANOIC-4,4-D2-ACID,2-(PROPYL-2,2-D2)-
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $550
- Updated
- 2021/12/16
- Product number
- D574
- Product name
- 2-(Propyl-2,2-d2)pentanoic-4,4-d2Acid
- Packaging
- 0.1g
- Price
- $1525
- Updated
- 2021/12/16
2-(PROPYL-2,2-D2)PENTANOIC-4,4-D2 ACID Chemical Properties,Usage,Production
Uses
Valproic acid-d4-1 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
References
[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Valproic acid, et al. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001 Sep 28;276(39):36734-41. DOI:10.1074/jbc.M101287200
[3] Han BR, et al. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013 Dec;30(6):2999-3005. DOI:10.3892/or.2013.2747
[4] Zhang ZH, et al. Valproic acid inhibits tumor angiogenesis in mice transplanted with Kasumi 1 leukemia cells. Mol Med Rep. 2013 Nov 28. DOI:10.3892/mmr.2013.1834
[5] Cohen OS, et al. Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats. Int J Dev Neurosci. 2013 Dec;31(8):740-50. DOI:10.1016/j.ijdevneu.2013.09.002
[6] Avery LB, et al. Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice. Mol Pharmacol. 2014 Jan;85(1):1-10. DOI:10.1124/mol.113.089755
[7] Platta CS, et al. Valproic acid induces Notch1 signaling in small cell lung cancer cells. J Surg Res. 2008 Jul;148(1):31-7. DOI:10.1016/j.jss.2008.03.008
2-(PROPYL-2,2-D2)PENTANOIC-4,4-D2 ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-(PROPYL-2,2-D2)PENTANOIC-4,4-D2 ACID Suppliers
- Tel
- +91-22-26355700
- Fax
- +91-22-26355701
- info@clearsynth.com
- Country
- India
- ProdList
- 9679
- Advantage
- 58
- Tel
- 025-84622273 17361806303
- kexin.zhou@haolvbiotech.com
- Country
- China
- ProdList
- 3019
- Advantage
- 58
- Tel
- 028-83243028 19136088901
- sinostandards@163.com
- Country
- China
- ProdList
- 4976
- Advantage
- 58
- Tel
- 020-3846 2365 19110442770
- 458677837@qq.com
- Country
- China
- ProdList
- 7775
- Advantage
- 58
- Tel
- 15195160625
- 2863565288@qq.com
- Country
- China
- ProdList
- 5192
- Advantage
- 58
- Tel
- 021-64400900 15800436310
- bessey@reertech.com
- Country
- China
- ProdList
- 4105
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 18003
- Advantage
- 58
- Tel
- 021-51600108 13062666369
- sales@isotopechem.com
- Country
- China
- ProdList
- 5000
- Advantage
- 58
- Tel
- 17301488900
- Fax
- 025-85560043
- judy.xia@synzest.com
- Country
- China
- ProdList
- 12582
- Advantage
- 58