1-O-HEXADECYL-PROPANEDIOL-(1,3)
Uses- Product Name
- 1-O-HEXADECYL-PROPANEDIOL-(1,3)
- CAS No.
- 23377-40-4
- Chemical Name
- 1-O-HEXADECYL-PROPANEDIOL-(1,3)
- Synonyms
- hexadecoxypropanol;3-hexadecoxypropan-1-ol;3-hexadecyloxy-1-propanol;Brincidofovir Impurity 6;3-hexadecyloxypropan- 1-ol;3-(hexadecyloxy)-1-propanol;3-(hexadecyloxy) propan-1-ol;1-O-Hexadecyl-1,3-propandiol;1-Propanol, 3-(hexadecyloxy)-;1-O-HEXADECYL-PROPANEDIOL-(1,3)
- CBNumber
- CB1238651
- Molecular Formula
- C19H40O2
- Formula Weight
- 300.52
- MOL File
- Mol file
1-O-HEXADECYL-PROPANEDIOL-(1,3) Property
- Melting point:
- 39 °C(Solv: hexane (110-54-3))
- Boiling point:
- 409.8±18.0 °C(Predicted)
- Density
- 0.868±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 14.89±0.10(Predicted)
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 23377-40-4
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-D0604
- Product name
- 1-Propanol,3-(hexadecyloxy)-
- Purity
- ≥98.0%
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- CS-D0604
- Product name
- 1-Propanol,3-(hexadecyloxy)-
- Purity
- ≥98.0%
- Packaging
- 5g
- Price
- $178
- Updated
- 2021/12/16
- Product number
- CS-D0604
- Product name
- 1-Propanol,3-(hexadecyloxy)-
- Purity
- ≥98.0%
- Packaging
- 10g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- LIP0003795
- Product name
- 3-(HEXADECYLOXY)PROPAN-1-OL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.08
- Updated
- 2021/12/16
- Product number
- A182606
- Product name
- 3-(Hexadecyloxy)propan-1-ol
- Purity
- 98%
- Packaging
- 250mg
- Price
- $24
- Updated
- 2021/12/16
1-O-HEXADECYL-PROPANEDIOL-(1,3) Chemical Properties,Usage,Production
Uses
Hexadecyl, 1-3-propylene glycol ether belongs to the class of alcohol ether organic compounds and is an intermediate used in the preparation of the drug hexadecyloxypropyltenovir disoproxil fumarate.
Synthesis
112-82-3
504-63-2
23377-40-4
In a 1000 mL round bottom flask, n-hexadecyl bromide (97.5 g, 0.32 mol, 1 eq.), 1,3-propanediol (73.5 g, 0.96 mol, 3 eq.), DMSO (200 mL), DMF (200 mL), and potassium hydroxide (72 g, 1.28 mol, 4 eq.) were added in turn and the reaction was stirred for 16 h at room temperature. Upon completion of the reaction, 500 mL of water was added to the reaction mixture and the pH was adjusted to neutral with 5 M hydrochloric acid solution, followed by extraction with ethyl acetate (500 mL x 2). The organic phases were combined and washed with saturated saline (500 mL x 2). The organic layer was collected, dried over anhydrous sodium sulfate (10 g), filtered and the filtrate concentrated under reduced pressure to give 102 g of yellow solid. Crystallization by petroleum ether gave 85 g of white flaky crystals in 88.4% yield.
References
[1] Patent: CN107936059, 2018, A. Location in patent: Paragraph 0011; 0029; 0030
[2] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 11, p. 3658 - 3665
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2002, vol. 177, # 12, p. 2887 - 2893
[4] Chemistry and Physics of Lipids, 1996, vol. 83, # 1, p. 77 - 85
[5] Molecular Therapy - Nucleic Acids, 2017, vol. 8, p. 158 - 168
1-O-HEXADECYL-PROPANEDIOL-(1,3) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-O-HEXADECYL-PROPANEDIOL-(1,3) manufacturers
- Product
- 1-O-HEXADECYL-PROPANEDIOL-(1,3) 23377-40-4
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-07-26