ChemicalBook > CAS DataBase List > GHRELIN (HUMAN)

GHRELIN (HUMAN)

Product Name
GHRELIN (HUMAN)
CAS No.
258279-04-8
Chemical Name
GHRELIN (HUMAN)
Synonyms
HuGHRL;GHRELIN HUGHRL;GHRELIN (HUMAN);GHRELIN (HUMAN) USP/EP/BP;M.W. 3370.90 C149H249N47O42;GHRELIN TRIFLUOROACETATE SALT;GHRELIN (HUMAN) TRIFLUOROACETATE;GS-S(N-OCTANOYL)-FLSPEHQRVQQRKESKKPPAKLQPR;GLY-SER-SER(N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG;GLY-SER-SER(O-N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG
CBNumber
CB1240638
Molecular Formula
C149H249N47O42
Formula Weight
3370.86
MOL File
258279-04-8.mol
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GHRELIN (HUMAN) Property

Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
-15°C
solubility 
Soluble in H2O
form 
Solid
Water Solubility 
Soluble in water, and 5% acetic acid.
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Safety

HS Code 
2933299090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64943
Product name
Ghrelin, human
Packaging
1mg
Price
$377
Updated
2023/06/20
Cayman Chemical
Product number
15072
Product name
Ghrelin (human)
Packaging
500μg
Price
$151
Updated
2022/04/27
Cayman Chemical
Product number
15072
Product name
Ghrelin (human)
Packaging
1mg
Price
$256
Updated
2022/04/27
Cayman Chemical
Product number
15072
Product name
Ghrelin (human)
Packaging
5mg
Price
$1052
Updated
2022/04/27
Tocris
Product number
1463
Product name
Ghrelin, human
Packaging
1
Price
$458
Updated
2021/12/16
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GHRELIN (HUMAN) Chemical Properties,Usage,Production

Uses

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. It is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated, which is necessary for biological activity.

Uses

The GHS-R (growth hormone secretagogue receptor) potently stimulates growth hormone release from the pituitary gland in vivo and in vitro. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. Ghrelin (human) is an activator of GHS-R1a.

Biological Activity

ghrelin is a specific endogenous ligand for the ghs receptor which can stimulate strong increase in circulating gh levels both in vitro and in vivo in a dose-dependent manner, human acylated ghrelin is the major active form that can cross the blood-brain barrier, and has an effection on the activity of arcute neurones with a much stronger affinity (ic50, 0.3×10-9m) than ghsr antagonist (d-lys3)-ghrp-6 (ic50, 0.9×10-6m)[1].ghrelin has effects in stimulating appetite, increasing secretion of gh and hypo-catabolism, improvement of gastrointestinal motility, increasing cardiac output, improvement of pulmonary function and anti-inflammatory effect.clinical applications of ghrelin in total gastrectomy, esophagectomy and neoadjuvant chemotherapy can stimulate food intake, improve guality of life scores and minimize adverse events. recently, ghrelin as a effective approach in the management of anorexia nervosa[2],cachexia[3], bw[4] and appetite loss[5], systemic inflammatory response[6]and cancer[7]. in conclusion, ghrelin is a promising candidate for treating catabolic states and enhancing immune function in cachexia or acquired immunodeficiency syndrome, as well as for treating eating disorders such as obesity and anorexia nervosa.

storage

Store at -20°C

References

1. m. traebert,* t. riediger,† s. whitebread,* e. scharrer† and h. a. schmid*. ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. journal of neuroendocrinology, 2002, vol. 14, 580–5862. hotta m, ohwada r, akamizu t, shibasaki t, takano k, kangawa k. ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study. endocr j. 2009;56:1119–28.3. nagaya n, itoh t, murakami s, oya h, uematsu m, miyatake k, et al. treatment of cachexia with ghrelin in patients with copd. chest. 2005;128:1187–93.4. adachi s, takiguchi s, okada k, yamamoto k, yamasaki m, miyata h, et al. effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase ii study. gastroenterology. 2010;138:1312–20.5. hiura y, takiguchi s, yamamoto k, kurokawa y, yamasaki m, nakajima k, et al. fall in plasma ghrelin concentrations after cisplatin-based chemotherapy in esophageal cancer patients. int j clin oncol. 2012;17:316–23.6. cheyuo c, jacob a, wang p. ghrelin-mediated sympathoinhibition and suppression of inflammation in sepsis. am j physiol endocrinol metab. 2012;302:e265–72.7. yoshida n, watanabe m, baba y, iwagami s, ishimoto t, iwatsuki m, et al. risk factors for pulmonary complications after esophagectomy for esophageal cancer. surg today. 2014;44:526–32.

GHRELIN (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

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258279-04-8, GHRELIN (HUMAN)Related Search:


  • H-GLY-SER-SER(OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH
  • H-GLY-SER-[SER(N-OCTANOYL)]-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH
  • GLY-SER-SER(N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG
  • GLY-SER-SER(O-N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG
  • GHRELIN (HUMAN)
  • GHRELIN (HUMAN) TRIFLUOROACETATE
  • GHRELIN TRIFLUOROACETATE SALT
  • GS-S(N-OCTANOYL)-FLSPEHQRVQQRKESKKPPAKLQPR
  • GHRELIN HUGHRL
  • HuGHRL
  • M.W. 3370.90 C149H249N47O42
  • H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-GlnGln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH
  • L-Arginine, glycyl-L-seryl-O-(1-oxooctyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-
  • GHRELIN (HUMAN) USP/EP/BP
  • L-Arginine,glycyl-L-seryl-O-(1-oxooctyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-a-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-a-glutamy
  • 258279-04-8
  • Cytokine
  • Peptide Receptors
  • Peptide
  • Ghrelin receptor