GHRELIN (HUMAN)

ChemicalBook > CAS DataBase List > GHRELIN (HUMAN)

Product Name: GHRELIN (HUMAN)
CAS No.: 258279-04-8
Chemical Name: GHRELIN (HUMAN)
Synonyms: HuGHRL;GHRELIN HUGHRL;GHRELIN (HUMAN);GHRELIN (HUMAN) USP/EP/BP;M.W. 3370.90 C149H249N47O42;GHRELIN TRIFLUOROACETATE SALT;GHRELIN (HUMAN) TRIFLUOROACETATE;GS-S(N-OCTANOYL)-FLSPEHQRVQQRKESKKPPAKLQPR;GLY-SER-SER(N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG;GLY-SER-SER(O-N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG
CBNumber: CB1240638
Molecular Formula: C149H249N47O42
Formula Weight: 3370.86
MOL File: 258279-04-8.mol

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GHRELIN (HUMAN) Property

Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: -15°C
solubility: Soluble in H2O
form: Solid
Water Solubility: Soluble in water, and 5% acetic acid.

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Safety

HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Alfa Aesar

Product number: J64943
Product name: Ghrelin, human
Packaging: 1mg
Price: $377
Updated: 2023/06/20

Cayman Chemical

Product number: 15072
Product name: Ghrelin (human)
Packaging: 500μg
Price: $151
Updated: 2022/04/27

Cayman Chemical

Product number: 15072
Product name: Ghrelin (human)
Packaging: 1mg
Price: $256
Updated: 2022/04/27

Cayman Chemical

Product number: 15072
Product name: Ghrelin (human)
Packaging: 5mg
Price: $1052
Updated: 2022/04/27

Tocris

Product number: 1463
Product name: Ghrelin, human
Packaging: 1
Price: $458
Updated: 2021/12/16

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GHRELIN (HUMAN) Chemical Properties,Usage,Production

Uses

Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is synthesized principally in the stomach. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. It is a peptide of 28 amino acids, in which the serine 3 residue is n-octanoylated, which is necessary for biological activity.

Uses

The GHS-R (growth hormone secretagogue receptor) potently stimulates growth hormone release from the pituitary gland in vivo and in vitro. It stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis. Ghrelin (human) is an activator of GHS-R1a.

Biological Activity

ghrelin is a specific endogenous ligand for the ghs receptor which can stimulate strong increase in circulating gh levels both in vitro and in vivo in a dose-dependent manner, human acylated ghrelin is the major active form that can cross the blood-brain barrier, and has an effection on the activity of arcute neurones with a much stronger affinity (ic50, 0.3×10-9m) than ghsr antagonist (d-lys3)-ghrp-6 (ic50, 0.9×10-6m)[1].ghrelin has effects in stimulating appetite, increasing secretion of gh and hypo-catabolism, improvement of gastrointestinal motility, increasing cardiac output, improvement of pulmonary function and anti-inflammatory effect.clinical applications of ghrelin in total gastrectomy, esophagectomy and neoadjuvant chemotherapy can stimulate food intake, improve guality of life scores and minimize adverse events. recently, ghrelin as a effective approach in the management of anorexia nervosa[2],cachexia[3], bw[4] and appetite loss[5], systemic inflammatory response[6]and cancer[7]. in conclusion, ghrelin is a promising candidate for treating catabolic states and enhancing immune function in cachexia or acquired immunodeficiency syndrome, as well as for treating eating disorders such as obesity and anorexia nervosa.

storage

Store at -20°C

References

1. m. traebert,* t. riediger,† s. whitebread,* e. scharrer† and h. a. schmid*. ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. journal of neuroendocrinology, 2002, vol. 14, 580–5862. hotta m, ohwada r, akamizu t, shibasaki t, takano k, kangawa k. ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study. endocr j. 2009;56:1119–28.3. nagaya n, itoh t, murakami s, oya h, uematsu m, miyatake k, et al. treatment of cachexia with ghrelin in patients with copd. chest. 2005;128:1187–93.4. adachi s, takiguchi s, okada k, yamamoto k, yamasaki m, miyata h, et al. effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase ii study. gastroenterology. 2010;138:1312–20.5. hiura y, takiguchi s, yamamoto k, kurokawa y, yamasaki m, nakajima k, et al. fall in plasma ghrelin concentrations after cisplatin-based chemotherapy in esophageal cancer patients. int j clin oncol. 2012;17:316–23.6. cheyuo c, jacob a, wang p. ghrelin-mediated sympathoinhibition and suppression of inflammation in sepsis. am j physiol endocrinol metab. 2012;302:e265–72.7. yoshida n, watanabe m, baba y, iwagami s, ishimoto t, iwatsuki m, et al. risk factors for pulmonary complications after esophagectomy for esophageal cancer. surg today. 2014;44:526–32.

GHRELIN (HUMAN) Preparation Products And Raw materials

Raw materials

Preparation Products

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258279-04-8, GHRELIN (HUMAN)Related Search:

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H-GLY-SER-SER(OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH

H-GLY-SER-[SER(N-OCTANOYL)]-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH

GLY-SER-SER(N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG

GLY-SER-SER(O-N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG

GHRELIN (HUMAN)

GHRELIN (HUMAN) TRIFLUOROACETATE

GHRELIN TRIFLUOROACETATE SALT

GS-S(N-OCTANOYL)-FLSPEHQRVQQRKESKKPPAKLQPR

GHRELIN HUGHRL

HuGHRL

M.W. 3370.90 C149H249N47O42

H-Gly-Ser-Ser(octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Lys-Ala-GlnGln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg-OH

L-Arginine, glycyl-L-seryl-O-(1-oxooctyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-α-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-α-glutamyl-L-seryl-L-lysyl-L-lysyl-L-prolyl-L-prolyl-L-alanyl-L-lysyl-L-leucyl-L-glutaminyl-L-prolyl-

GHRELIN (HUMAN) USP/EP/BP

L-Arginine,glycyl-L-seryl-O-(1-oxooctyl)-L-seryl-L-phenylalanyl-L-leucyl-L-seryl-L-prolyl-L-a-glutamyl-L-histidyl-L-glutaminyl-L-arginyl-L-valyl-L-glutaminyl-L-glutaminyl-L-arginyl-L-lysyl-L-a-glutamy

258279-04-8

Cytokine

Peptide Receptors

Peptide

Ghrelin receptor