(1S)-7-Isopropylidene-1,2,3,3aα,4,5,6,7,8,8aβ-decahydro-1β-hydroxy-1-methyl-4-methyleneazulen-6-one
- Product Name
- (1S)-7-Isopropylidene-1,2,3,3aα,4,5,6,7,8,8aβ-decahydro-1β-hydroxy-1-methyl-4-methyleneazulen-6-one
- CAS No.
- 102130-90-5
- Chemical Name
- (1S)-7-Isopropylidene-1,2,3,3aα,4,5,6,7,8,8aβ-decahydro-1β-hydroxy-1-methyl-4-methyleneazulen-6-one
- Synonyms
- Isoprocurcumenol;6(1H)-Azulenone,octahydro-1-hydroxy-1-methyl-4-methylene-7-(1-methylethylidene)-, (1S,3aR,8aS)-;(1S)-7-Isopropylidene-1,2,3,3aα,4,5,6,7,8,8aβ-decahydro-1β-hydroxy-1-methyl-4-methyleneazulen-6-one;[1S-(1alpha,3abeta,8aalpha)]-Octahydro-1-hydroxy-1-methyl-4-methylene-7-(1-methylethylidene)-6(1H)-azulenone
- CBNumber
- CB12417146
- Molecular Formula
- C15H22O2
- Formula Weight
- 234.33
- MOL File
- 102130-90-5.mol
(1S)-7-Isopropylidene-1,2,3,3aα,4,5,6,7,8,8aβ-decahydro-1β-hydroxy-1-methyl-4-methyleneazulen-6-one Property
- form
- Solid
- color
- White to off-white
- Cosmetics Ingredients Functions
- SKIN CONDITIONING - MISCELLANEOUS
SKIN PROTECTING
HAIR CONDITIONING - InChI
- InChI=1S/C15H22O2/c1-9(2)12-8-13-11(5-6-15(13,4)17)10(3)7-14(12)16/h11,13,17H,3,5-8H2,1-2,4H3/t11-,13-,15-/m0/s1
- InChIKey
- ITIGZFMSPAFZAE-WHOFXGATSA-N
- SMILES
- [C@@]1(O)(C)[C@]2([H])[C@]([H])(C(=C)CC(=O)/C(=C(\C)/C)/C2)CC1
N-Bromosuccinimide Price
- Product number
- CFN92620
- Product name
- Isoprocurcumenol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $418
- Updated
- 2021/12/16
(1S)-7-Isopropylidene-1,2,3,3aα,4,5,6,7,8,8aβ-decahydro-1β-hydroxy-1-methyl-4-methyleneazulen-6-one Chemical Properties,Usage,Production
Uses
Isoprocurcumenol is a guaiane type sesquiterpene, that can be isolated from Curcuma comosa. Isoprocurcumenol can activate EGFR signaling. Isoprocurcumenol increases the phosphorylation of ERK and AKT. Isoprocurcumenol promotes the proliferation of keratinocytes[1][2][3].
Definition
ChEBI: (1alpha,4beta,5beta)-4-Hydroxy-7(11),10(14)-guaiadien-8-one is a sesquiterpenoid.
IC 50
ERK; Akt
References
[1] Qu Y, et al. Sesquiterpenes from Curcuma comosa. J Nat Med. 2009 Jan;63(1):102-4. DOI:10.1007/s11418-008-0282-8
[2] Anuchapreeda S, et al. Cytotoxicity and inhibition of leukemic cell proliferation by sesquiterpenes from rhizomes of Mah-Lueang (Curcuma cf. viridiflora Roxb.). Bioorg Med Chem Lett. 2018 Feb 1;28(3):410-414. DOI:10.1016/j.bmcl.2017.12.029
[3] Kwon PK, et al. Isoprocurcumenol Supports Keratinocyte Growth and Survival through Epidermal Growth Factor Receptor Activation. Int J Mol Sci. 2021 Nov 22;22(22):12579. DOI:10.3390/ijms222212579
(1S)-7-Isopropylidene-1,2,3,3aα,4,5,6,7,8,8aβ-decahydro-1β-hydroxy-1-methyl-4-methyleneazulen-6-one Preparation Products And Raw materials
Raw materials
Preparation Products
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