ChemicalBook > CAS DataBase List > 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

Product Name: 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
CAS No.: 102394-31-0
Chemical Name: 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
Synonyms: AF-DX 116;Brn 4212983;(100158-38-1) otenzepad;Otenzepad, 10 mM in DMSO;ethyl)-7-piperidinyl)acetyl)-;AF-DX 116 (Otenzepad), M2 antagonist;Muscarinic acetylcholine receptor,Otenzepad,Inhibitor,mAChR,inhibit,memory;6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one,5,11-dihydro-11-((2-((diethylamino)m;11-(2-(2-((Diethylamino)methyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one;11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE
CBNumber: CB1242627
Molecular Formula: C24H31N5O2
Formula Weight: 421.54
MOL File: 102394-31-0.mol

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11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Property

Boiling point:: 573.2±45.0 °C(Predicted)
Density: 1.171
storage temp.: room temp
solubility: DMSO: soluble5mg/mL (clear solution; warmed)
form: powder
pka: 11.29±0.20(Predicted)
color: white to beige

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0435
Product name: AF-DX 116
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $112
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0435
Product name: AF-DX 116
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $301
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.05821
Product name: AF-DX 116 - CAS 102394-31-0 - Calbiochem
Packaging: 10MG
Price: $205
Updated: 2022/05/15

Tocris

Product number: 1105
Product name: AF-DX 116
Purity: ≥98%(HPLC)
Packaging: 10
Price: $171
Updated: 2021/12/16

Tocris

Product number: 1105
Product name: AF-DX 116
Purity: ≥98%(HPLC)
Packaging: 50
Price: $717
Updated: 2021/12/16

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11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Chemical Properties,Usage,Production

Uses

AF-DX 116 has been used as an M2 muscarinic acetylcholine receptor (M2AChR) selective antagonist to study the influence of M2AChR in the regulation of both basal and carbachol-stimulated long-term potentiation at the dentate gyrus (DG-LTP) and pro-nerve growth factor (proNGF) secretion in hippocampal cells of young diabetic rats.

Definition

ChEBI: 11-[2-[2-(diethylaminomethyl)-1-piperidinyl]-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one is a benzodiazepine.

Biological Activity

Selective M 2 muscarinic receptor antagonist. K i values are 64, 417, 786, 211 and 5130 nM for human recombinant M 2 , M 1 , M 3 , M 4 and M 5 muscarinic receptors, respectively.

Biochem/physiol Actions

AF-DX 116 raises blood pressure and heart rate in a rat model of hypotension induced by repeated cold stress. Thus, it may be used as a therapeutic for hypotension related to vagotonia type autonomic dysfunction.

storage

Room temperature

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Suppliers

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102394-31-0, 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONERelated Search:

Hexamethyldisilazane CHEMBRDG-BB 4015189 DIMETHYL-PIPERIDIN-2-YLMETHYL-AMINE 1-ethylpiperidine-2-methylamine C-(1-METHYL-PIPERIDIN-2-YL)-METHYLAMINE Methyl[(1-methylpiperidin-2-yl)methyl]amine 3-Amino-2-phenylamino-pyridine ETHYL[(1-METHYLPIPERIDIN-2-YL)METHYL]AMINE 5,11-Dihydropyrido[2,3-b][1,4]benzodiazepin-6-one ETHYL[(1-ETHYLPIPERIDIN-2-YL)METHYL]AMINE 2-(2-methylpiperidin-1-yl)ethanamine 2-amino-N-(3-pyridinyl)benzamide (1-ETHYL-2-PIPERIDINYL)-N-METHYLMETHANAMINE 2-(2-DIETHYLAMINOETHYL)PIPERIDINE 11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

11-[[2-[(DIETHYLAMINO)METHYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE

AF-DX 116

6h-pyrido(2,3-b)(1,4)benzodiazepin-6-one,5,11-dihydro-11-((2-((diethylamino)m

ethyl)-7-piperidinyl)acetyl)-

11-((2-((Diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-(6H)-pyrido[2.3-b][1.4]benzodiazepin-6-one

6H-Pyrido(2,3-B)(1,4)benzodiazepin-6-one, 11-((2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-

6H-Pyrido(2,3-B)(1,4)benzodiazepin-6-one, 5,11-dihydro-11-((2-((diethylamino)methyl)-7-piperidinyl)acetyl)-

Brn 4212983

11-[2-[2-[(Diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one

11-(2-(2-((Diethylamino)methyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

(100158-38-1) otenzepad

6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 11-[2-[2-[(diethylamino)methyl]-1-piperidinyl]acetyl]-5,11-dihydro-

Muscarinic acetylcholine receptor,Otenzepad,Inhibitor,mAChR,inhibit,memory

AF-DX 116 (Otenzepad), M2 antagonist

Otenzepad, 10 mM in DMSO

102394-31-0

C24H31N5O2

Acetylcholine receptor

Muscarinic