ChemicalBook > CAS DataBase List > 2,4-DIFLUOROCINNAMIC ACID

2,4-DIFLUOROCINNAMIC ACID

Product Name
2,4-DIFLUOROCINNAMIC ACID
CAS No.
94977-52-3
Chemical Name
2,4-DIFLUOROCINNAMIC ACID
Synonyms
RARECHEM BK HW 0121;2,4-DifluorocinnamicAci;2,4-DIFLUOROCINNAMIC ACID;2,4-DIFLUOROCINNAMADEHYDE;trans-2,4-Difluorocinnamic;2,4-DifluorocinnamicAcid>trans-2,4-Difluorociamic acid;(E)-2,4-Difluorocinnamic Acid;RANS-2,4-DIFLUOROCINNAMIC ACID;TRANS-2,4-DIFLUOROCINNAMIC ACID
CBNumber
CB1243114
Molecular Formula
C9H6F2O2
Formula Weight
184.14
MOL File
94977-52-3.mol
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2,4-DIFLUOROCINNAMIC ACID Property

Melting point:
216-218 °C (lit.)
Boiling point:
272.0±25.0 °C(Predicted)
Density 
1.3056 (estimate)
storage temp. 
Storage temp. 2-8°C
pka
4.29±0.13(Predicted)
form 
powder to crystal
color 
White to Light yellow
CAS DataBase Reference
94977-52-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-37/39-26/37/39
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
290335
Product name
trans-2,4-Difluorocinnamic acid
Purity
98%
Packaging
5g
Price
$149
Updated
2023/06/20
TCI Chemical
Product number
D2343
Product name
2,4-Difluorocinnamic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$79
Updated
2023/06/20
TRC
Product number
D447613
Product name
2,4-Difluorocinnamic Acid
Packaging
1g
Price
$75
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD76238
Product name
trans-2,4-Difluorocinnamic acid
Packaging
10g
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-W017017
Product name
(E)-3-(2,4-Difluorophenyl)acrylicacid
Packaging
100g
Price
$313
Updated
2021/12/16
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2,4-DIFLUOROCINNAMIC ACID Chemical Properties,Usage,Production

Chemical Properties

White to pale yellow powder

Uses

trans-2,4-Difluorocinnamic acid may be used in chemical synthesis.

Synthesis

4519-40-8

5329-14-6

79-10-7

94977-52-3

Example 5: Synthesis of (E)-3-(2,4-difluorophenyl)acrylic acid 1. 77.5 g of 2,3-difluoroaniline was slowly added dropwise to a mixture consisting of 124 mL of concentrated hydrochloric acid, sulfuric acid and 472 mL of water at 0 °C. 2. maintaining the reaction temperature at 0 °C, a solution of 48.3 g of sodium nitrite dissolved in 90 mL of water was slowly added dropwise. 3. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0°C for 30 minutes. 4. sulfamic acid was added to quench the excess nitrite. 5. In a separate vessel, 0.34 g of palladium(II) acetate was added to 54.8 g of acrylic acid and the mixture was heated to 47°C. 6. the diazonium salt solution prepared in step 4 was slowly added dropwise over a period of 2 hours at 47 °C, controlling the reaction temperature to not exceed 49 °C. the reaction was carried out at the same time. 7. after completion of the dropwise addition, the reaction mixture was continued to be stirred at the same temperature for 2 hours. 8. After completion of the reaction, the mixture was cooled to room temperature and the solid product was collected by filtration. 9. The solid product was washed with water and dried. 10. 10. 105.1 g of (E)-3-(2,4-difluorophenyl)acrylic acid was obtained in 95% yield of the theoretical value, with a melting point of 204-205 °C. The reaction was carried out at the same temperature.

References

[1] Patent: US2002/115885, 2002, A1

2,4-DIFLUOROCINNAMIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4-DIFLUOROCINNAMIC ACID Suppliers

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View Lastest Price from 2,4-DIFLUOROCINNAMIC ACID manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
2,4-DIFLUOROCINNAMIC ACID 94977-52-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 mt
Release date
2024-12-09
Shaanxi Dideu New Materials Co. Ltd
Product
2,4-DIFLUOROCINNAMIC ACID 94977-52-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-03-01
Zhuozhou Wenxi import and Export Co., Ltd
Product
2,4-DIFLUOROCINNAMIC ACID 94977-52-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

94977-52-3, 2,4-DIFLUOROCINNAMIC ACIDRelated Search:

TRANS-2,3-DIFLUOROCINNAMIC ACID Acrylic acid 4-FLUOROCINNAMIC ACID TRANS-3,5-DIFLUOROCINNAMIC ACID,3,5-DIFLUOROCINNAMIC ACID 6-BROMO-2,3-DIFLUOROCINNAMIC ACID 3-CHLORO-2,6-DIFLUOROCINNAMIC ACID 2,5-DIFLUOROCINNAMIC ACID,TRANS-2,5-DIFLUOROCINNAMIC ACID,trans-2,5-Difluorocinnamic acid 97% 2-CHLORO-3,6-DIFLUOROCINNAMIC ACID 3,5-DIFLUOROCINNAMIC ACID,trans-3,5-Difluorocinnamic acid 98%,TRANS-3,5-DIFLUOROCINNAMIC ACID trans-3,4-Difluorocinnamic acid 97%,TRANS-3,4-DIFLUOROCINNAMIC ACID,3,4-DIFLUOROCINNAMIC ACID 2,4-Difluorocinnamic acid ethyl ester trans-2,6-Difluorocinnamic acid 98%,TRANS-2,6-DIFLUOROCINNAMIC ACID,2,6-DIFLUOROCINNAMIC ACID 2,4-Difluorocinnamadehyde TRANS-2,3-DIFLUOROCINNAMIC ACID,2,3-DIFLUOROCINNAMIC ACID,trans-2,3-Difluorocinnamic acid 97% 2,4-DIFLUOROCINNAMIC ACID,TRANS-2,4-DIFLUOROCINNAMIC ACID

  • (2E)-3-(2,4-DIFLUOROPHENYL)-2-PROPENOIC ACID
  • 3-(2,4-DIFLUOROPHENYL)-2-PROPENOIC ACID
  • 3-(2,4-DIFLUOROPHENYL)ACRYLIC ACID
  • 2,4-DIFLUOROCINNAMIC ACID
  • RARECHEM BK HW 0121
  • TRANS-2,4-DIFLUOROCINNAMIC ACID
  • trans-2,4-Difluorocinnamic
  • trans-2,4-Difluorocinnamic acid 98%
  • trans-2,4-Difluorocinnamicacid98%
  • 2,4-DIFLUOROCINNAMADEHYDE
  • RANS-2,4-DIFLUOROCINNAMIC ACID
  • trans-2,4-Difluorociamic acid
  • (E)-3-(2,4-Difluorophenyl)acrylic acid
  • (2E)-3-(2,4-Difluorophenyl)prop-2-enoic acid, (E)-3-(2,4-Difluorophenyl)acrylic acid
  • 2,4-DifluorocinnamicAcid&gt
  • 2-Propenoic acid, 3-(2,4-difluorophenyl)-, (2E)-
  • 2,4-DifluorocinnamicAci
  • 2,4-DIFLUOROCINNAMIC ACID USP/EP/BP
  • (E)-2,4-Difluorocinnamic Acid
  • <i>trans</i>-2,4-Difluorocinnamic acid
  • 94977-52-3
  • F2C6H3CHCHCO2H
  • Organic Building Blocks
  • Building Blocks
  • C9
  • Carboxylic Acids
  • Carbonyl Compounds
  • C9
  • Carbonyl Compounds
  • Carboxylic Acids
  • Cinnamic acid