4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL

Product Name: 4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL
CAS No.: 38214-71-0
Chemical Name: 4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL
Synonyms: VRT-532;CFpot 532;VRT 532,VRT532;VRT-532 >=98% (HPLC);VRT-532, 10 mM in DMSO;4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL;PHENOL, 4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)-
CBNumber: CB12446623
Molecular Formula: C16H14N2O
Formula Weight: 250.3
MOL File: 38214-71-0.mol

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4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL Property

Melting point:: 153-154 °C(Solv: acetic acid (64-19-7))
Boiling point:: 472.9±40.0 °C(Predicted)
Density: 1.213±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >20mg/mL
form: solid
pka: 9.16±0.43(Predicted)
color: White to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: V2390
Product name: VRT-532
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $140
Updated: 2022/05/15

American Custom Chemicals Corporation

Product number: CBL0000388
Product name: VRT-532
Purity: 95.00%
Packaging: 5MG
Price: $504.91
Updated: 2021/12/16

Crysdot

Product number: CD11132131
Product name: 4-Methyl-2-(5-phenyl-1H-pyrazol-3-yl)phenol
Purity: 95+%
Packaging: 1g
Price: $528
Updated: 2021/12/16

Alichem

Product number: 38214710
Product name: 4-Methyl-2-(5-phenyl-1h-pyrazol-3-yl)phenol
Packaging: 1g
Price: $578.86
Updated: 2021/12/16

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4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL Chemical Properties,Usage,Production

Uses

VRT-532 (CFpot-532) is a potent is a potent CFTR modulator. VRT-532 enhances channel activity in G551D-CFTR and intrinsic ATPase activity of G551D-CFTR. VRT-532 has the potential for the research of cystic fibrosis[1][2].

References

[1] Pasyk S, et al. Direct interaction of a small-molecule modulator with G551D-CFTR, a cystic fibrosis-causing mutation associated with severe disease. Biochem J. 2009 Feb 15;418(1):185-90. DOI:10.1042/BJ20081424
[2] Wang Y, et al. Correctors promote maturation of cystic fibrosis transmembrane conductance regulator (CFTR)-processing mutants by binding to the protein. J Biol Chem. 2007 Nov 16;282(46):33247-33251. DOI:10.1074/jbc.C700175200

4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL Suppliers

China 15 United States 5 Global 20

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38214-71-0, 4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOLRelated Search:

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4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)PHENOL

PHENOL, 4-METHYL-2-(5-PHENYL-1H-PYRAZOL-3-YL)-

CFpot 532

VRT-532

VRT-532 >=98% (HPLC)

VRT 532,VRT532

VRT-532, 10 mM in DMSO

38214-71-0