ChemicalBook > CAS DataBase List > 4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL

4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL

Product Name: 4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL
CAS No.: 53903-51-8
Chemical Name: 4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL
Synonyms: UKRORGSYN-BB BBV-5105736;4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL;Phenol, 4-chloro-2-(trifluoromethyl)-
CBNumber: CB12448384
Molecular Formula: C7H4ClF3O
Formula Weight: 196.55
MOL File: 53903-51-8.mol

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4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL Property

Boiling point:: 189.0±35.0 °C(Predicted)
Density: 1.474±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 7.54±0.43(Predicted)
Appearance: Off-white to light brown Solid

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Safety

HS Code: 2908990000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B419415
Product name: 4-Chloro-2-(trifluoromethyl)phenol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W022136
Product name: 4-Chloro-2-(trifluoromethyl)phenol
Packaging: 1g
Price: $88
Updated: 2021/12/16

Apolloscientific

Product number: PC500173
Product name: 4-Chloro-2-(trifluoromethyl)phenol
Packaging: 1g
Price: $508
Updated: 2021/12/16

ChemScene

Product number: CS-W022136
Product name: 4-Chloro-2-(trifluoromethyl)phenol
Packaging: 10g
Price: $666
Updated: 2021/12/16

AK Scientific

Product number: Z0673
Product name: 4-Chloro-2-trifluoromethylphenol
Packaging: 10g
Price: $1277
Updated: 2021/12/16

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4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL Chemical Properties,Usage,Production

Synthesis

445-03-4

53903-51-8

The general procedure for the synthesis of 2-trifluoromethyl-4-chlorophenol from 2-amino-5-chlorobenzotrifluoride was as follows: an aqueous solution (2 mL) of NaNO2 (0.458 g, 6.63 mmol) was slowly added to a cooled mixture of 4-chloro-2-trifluoromethylaniline (1.08 g, 5.52 mmol) dissolved in 33% H2SO4 (40 mL) at 0 °C in a cooled mixture of 33% H2SO4 (40 mL). After 3 hours of reaction, urea (0.100 g, 1.67 mmol) was added and stirring was continued for 10 minutes. Subsequently, the reaction mixture was poured into 100 mL of preheated 33% H2SO4 and heated to reflux for 1 hour and then cooled to room temperature. The reaction mixture was extracted with EtOAc, the organic phase was washed sequentially with water and saturated NaCl solution, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. Purification by silica gel column chromatography with 20% EtOAc/hexane as eluent gave 4-chloro-2-trifluoromethylphenol (0.245 g, 23% yield). The product was detected by mass spectrometry (ion spray) showing m/z = 195 (M-1) and 1H NMR (CDCl3) data as follows: δ 7.49 (d, 1H), 7.38 (dd, 1H), 6.91 (d, 1H), 5.44 (brs, 1H).

References

[1] Patent: WO2005/92835, 2005, A1. Location in patent: Page/Page column 37

4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL manufacturers

Career Henan Chemical Co

Product: 4-CHLORO-2-(TRIFLUOROMETHYL)PHENOL 53903-51-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 1ton
Release date: 2020-01-08

53903-51-8, 4-CHLORO-2-(TRIFLUOROMETHYL)PHENOLRelated Search:

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53903-51-8