ChemicalBook > CAS DataBase List > TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE

TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE

Product Name: TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE
CAS No.: 479691-42-4
Chemical Name: TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE
Synonyms: 1-Boc-4-(4-chloropyrimidin-2-yl)piperazine;4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate;1-Boc-4-(4-chloropyrimidin-2-yl)-piperazine, CAS 479691-42-4;TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE;4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperazinecarboxylic acid, 4-(4-chloro-2-pyrimidinyl)-, 1,1-dimethylethyl ester
CBNumber: CB12449912
Molecular Formula: C13H19ClN4O2
Formula Weight: 298.77
MOL File: 479691-42-4.mol

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TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE Property

Boiling point:: 434.5±55.0 °C(Predicted)
Density: 1.253±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 3.46±0.40(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B810365
Product name: tert-Butyl4-(4-Chloropyrimidin-2-yl)piperazine-1-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: J50914
Product name: 1-Boc-4-(4-Chloropyrimidin-2-yl)piperazine
Packaging: 250mg
Price: $61
Updated: 2021/12/16

Matrix Scientific

Product number: 072048
Product name: 1-Boc-4-(4-Chloropyrimidin-2-yl)piperazine
Purity: 95+%
Packaging: 1g
Price: $301
Updated: 2021/12/16

AK Scientific

Product number: J50914
Product name: 1-Boc-4-(4-Chloropyrimidin-2-yl)piperazine
Packaging: 5g
Price: $460
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0069317
Product name: 1-BOC-4-(4-CHLOROPYRIMIDIN-2-YL)-PIPERAZINE
Purity: 95.00%
Packaging: 1G
Price: $907.83
Updated: 2021/12/16

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TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

1193-21-1

57260-71-6

479691-42-4

Step 1: Dissolve 4,6-dichloropyrimidine (2.00 g, 13.4 mmol) and N-BOC-piperazine (3.00 g, 16.1 mmol) in 60 mL of 2-propanol and add triethylamine (4.7 mL, 33.6 mmol). The reaction mixture was heated to reflux for 2 hours. After the reaction was completed, the mixture was concentrated under reduced pressure. Dichloromethane was added to the residue and the organic layer was washed with water. The aqueous layer was back-extracted with dichloromethane and all organic layers were combined and dried over anhydrous sodium sulfate. The dried organic layer was concentrated under reduced pressure, and the crude product obtained was purified by silica gel column chromatography (eluent ratio of ethyl acetate:hexane=1:2) to afford tert-butyl 4-(6-chloropyrimidin-2-yl)piperazine-1-carboxylate (3.80 g, 95% yield) as a white solid.

References

[1] Patent: WO2009/145360, 2009, A1. Location in patent: Page/Page column 116

TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE Suppliers

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479691-42-4, TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATERelated Search:

TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE

1-Boc-4-(4-chloropyrimidin-2-yl)piperazine

4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate

4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

TERT-BUTYL 4-(4-CHLOROPYRIMIDIN-2-YL)PIPERAZINE-1-CARBOXYLATE

1-Piperazinecarboxylic acid, 4-(4-chloro-2-pyrimidinyl)-, 1,1-dimethylethyl ester

1-Boc-4-(4-chloropyrimidin-2-yl)-piperazine, CAS 479691-42-4

479691-42-4