ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
- Product Name
- ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
- CAS No.
- 13720-94-0
- Chemical Name
- ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE
- Synonyms
- NSC 136916;NSC 109461;AURORA 18125;4-CHLORO-3-QUINOLINECARBOXYLATE;ETHYL 4-CHLOROQUINOLINE-3-CARBOXYLATE;ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE;4-CHLORO-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester;4-chloro-3-Quinolinecarboxylic acid ethyl ester (6CI 8CI 9CI ACI);3-Quinolinecarboxylic acid, 4-chloro-, ethyl ester (6CI, 8CI, 9CI, ACI)
- CBNumber
- CB1245057
- Molecular Formula
- C12H10ClNO2
- Formula Weight
- 235.67
- MOL File
- 13720-94-0.mol
ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE Property
- Melting point:
- 46-48°C
- Boiling point:
- 128-129 °C(Press: 0.2 Torr)
- Density
- 1.286
- storage temp.
- Storage temp. -20°C
- pka
- 1.78±0.24(Predicted)
- form
- powder to crystal
- color
- White to Orange to Green
- InChIKey
- DWXQUAHMZWZXHP-UHFFFAOYSA-N
- CAS DataBase Reference
- 13720-94-0(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38-36
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 2933499090
N-Bromosuccinimide Price
- Product number
- JRD0194
- Product name
- Ethyl 4-chloroquinoline-3-carboxylate
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $286
- Updated
- 2025/07/31
- Product number
- E1201
- Product name
- Ethyl 4-Chloroquinoline-3-carboxylate
- Packaging
- 200MG
- Price
- $65
- Updated
- 2025/07/31
- Product number
- E1201
- Product name
- Ethyl 4-Chloroquinoline-3-carboxylate
- Packaging
- 1G
- Price
- $188
- Updated
- 2024/03/01
- Product number
- E903695
- Product name
- Ethyl 4-Chloroquinoline-3-carboxylate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FC147914
- Product name
- 4-Chloro-quinoline-3-carboxylic acid methylester
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE Chemical Properties,Usage,Production
Uses
Ethyl 4-chloroquinoline-3-carboxylate is used as organic chemical synthesis intermediate.
Synthesis
26892-90-0
13720-94-0
Synthesis of ethyl 4-chloroquinoline-3-carboxylate (A2): ethyl 4-hydroxyquinoline-3-carboxylate (A1) (1.5 g, 7 mmol) solid was placed in a reaction vial and phosphorus oxychloride (POCl3) (2.2 g, 1.3 mL, 14 mmol) was added. The reaction mixture was heated at 110 °C for 20 min. Upon completion of the reaction, the mixture was slowly poured into a pre-cooled mixture of aqueous ammonia solution (28-30%) and ice and stirred until a granular solid was formed. The reaction mixture was extracted with ether (3 x 40 mL), the organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give an oily product. After standing, the product crystallized (1.44 g, 6 mmol, 87% yield) and could be used for subsequent reactions without further purification.
References
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 21, p. 6351 - 6363
[2] Patent: WO2005/123686, 2005, A1. Location in patent: Page/Page column 75-76
[3] European Journal of Medicinal Chemistry, 2015, vol. 103, p. 1 - 16
[4] Patent: CN108623589, 2018, A. Location in patent: Paragraph 0142; 0149
[5] Patent: CN108623581, 2018, A. Location in patent: Page/Page column 7
ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE Suppliers
- Tel
- --
- Fax
- --
- aurora@aurorafinechemicals.com
- Country
- Austria
- ProdList
- 6625
- Advantage
- 72
View Lastest Price from ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE manufacturers
- Product
- ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE 13720-94-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-08-11
- Product
- ETHYL 4-CHLORO-3-QUINOLINECARBOXYLATE 13720-94-0
- Price
- US $0.01/KG
- Min. Order
- 500g
- Purity
- 98%; 99%
- Supply Ability
- 500g；1kg； 10kg; 25kg
- Release date
- 2020-01-08