FRESELESTAT

Product Name: FRESELESTAT
CAS No.: 208848-19-5
Chemical Name: FRESELESTAT
Synonyms: ONO6818;ONO 6818;ONO-6818;Freselesat;ONO-PO-736;FRESELESTAT;Freselestat (ONO-6818);5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide;1(6H)-PyriMidineacetaMide,5-aMino-N-[1-[[5-(1,1-diMethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-Methylpropyl]-6-oxo-2-phenyl-
CBNumber: CB12451308
Molecular Formula: C23H28N6O4
Formula Weight: 452.51
MOL File: 208848-19-5.mol

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FRESELESTAT Property

Melting point:: 151-153oC
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.43±0.46(Predicted)
form: Solid
color: Off-White to Pale Yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5651
Product name: ONO6818
Purity: ≥98%(HPLC)
Packaging: 10
Price: $252
Updated: 2021/12/16

TRC

Product number: F764500
Product name: Freselestat
Packaging: 2.5mg
Price: $120
Updated: 2021/12/16

TRC

Product number: F764500
Product name: Freselestat
Packaging: 25mg
Price: $990
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008113
Product name: ONO-6818
Purity: 95.00%
Packaging: 1G
Price: $918.23
Updated: 2021/12/16

ChemScene

Product number: CS-0007925
Product name: Freselestat
Packaging: 10mg
Price: $600
Updated: 2021/12/16

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FRESELESTAT Chemical Properties,Usage,Production

Uses

Freselestat is a highly potent nonpeptidic orally active inhibitor of human neutrophil elastase (HNE) and can be used as treatment for neutrophil-predominant inflammatory lung diseases.

in vivo

Freselestat (ONO-6818; 10-100 mg/kg; oral administration; daily; for 8 weeks) treatment attenuates dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid. ONO-6818 inhibits acute lung injury induced by HNE by minimizing lung hemorrhage and accumulation of neutrophils in the lung^[1].

Animal Model:	Male Wistar rats (228 g) induced by human neutrophil elastase (HNE)^[1]
Dosage:	10 mg/kg, 100 mg/kg
Administration:	Oral administration; daily; for 8 weeks
Result:	Attenuated dose-dependently HNE-induced increases in lung myeloperoxidase activity, hemoglobin, and neutrophil count in bronchoalveolar lavage fluid.

storage

Store at -20°C

FRESELESTAT Preparation Products And Raw materials

Raw materials

Preparation Products

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FRESELESTAT Suppliers

China 19 India 1 United Kingdom 1 United States 9 Global 30

Shanghai Boyle Chemical Co., Ltd.

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Absin Bioscience Inc.

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208848-19-5, FRESELESTATRelated Search:

FRESELESTAT

1(6H)-PyriMidineacetaMide,5-aMino-N-[1-[[5-(1,1-diMethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-Methylpropyl]-6-oxo-2-phenyl-

ONO 6818

ONO6818

ONO-6818

ONO-PO-736

5-Amino-N-[1-[[5-(1,1-dimethylethyl)-1,3,4-oxadiazol-2-yl]carbonyl]-2-methylpropyl]-6-oxo-2-phenyl-1(6H)-pyrimidineacetamide

Freselesat

Freselestat (ONO-6818)

208848-19-5

C23H28N6O4