4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE
- Product Name
- 4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE
- CAS No.
- 140873-26-3
- Chemical Name
- 4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE
- Synonyms
- 4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE;Benzamide, 4-amino-N-[2-[[(cyanoamino)[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]imino]methyl]amino]ethyl]-
- CBNumber
- CB12453418
- Molecular Formula
- C26H35N7O2
- Formula Weight
- 477.6
- MOL File
- 140873-26-3.mol
4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE Property
- storage temp.
- Store at +4°C
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Powder
N-Bromosuccinimide Price
- Product number
- A637893
- Product name
- Aminopotentidine
- Packaging
- 1mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- B6417
- Product name
- Aminopotentidine
- Packaging
- 10mg
- Price
- $282
- Updated
- 2021/12/16
- Product number
- API0019253
- Product name
- AMINOPOTENTIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.76
- Updated
- 2021/12/16
4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE Chemical Properties,Usage,Production
Uses
Aminopotentidine is a histamine H2 receptor antagonist with KB values of 220 nM and 280 nM for human and guinea pig H2 receptors, respectively. It can also serve as a precursor for the synthesis of [125I] iodo derivatives[1].
Definition
ChEBI: Aminopotentidine is a benzamide obtained by formal condensation of the carboxy group of 4-aminobenzoic acid with the primary amino group of 1-(2-aminoethyl)-2-cyano-3-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}guanidine. It has a role as a H2-receptor antagonist. It is a member of guanidines, a member of benzamides, a substituted aniline, a nitrile, an aromatic ether and a member of piperidines.
Biological Activity
H 2 antagonist (K B values are 220 and 280 nM at human and guinea pig H 2 receptors respectively) and precursor for the synthesis of the [ 125 I]-iodo derivative.
IC 50
H2 Receptor: 220 nM (Kb)
References
[1] Hirschfeld J, et al. Iodoaminopotentidine and related compounds: a new class of ligands with high affinity and selectivity for the histamine H2 receptor[J]. Journal of medicinal chemistry, 1992, 35(12): 2231-2238. DOI:10.1021/jm00090a013
4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
4-AMINO-N-[2-[[(CYANOAMINO)[[3-[3-(1-PIPERIDINYLMETHYL)PHENOXY]PROPYL]IMINO]METHYL]AMINO]ETHYL]BENZAMIDE Suppliers
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