N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE

Product Name: N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE
CAS No.: 527680-56-4
Chemical Name: N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE
Synonyms: PH-568487;PHA 568487;PHA 568487 free base;(R)-N-(Quinuclidin-3-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide;1,4-Benzodioxin-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-;N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE;macrophage,fracture,acetylcholine,Inhibitor,ischemic,bone,receptor,PHA 568487 free base,cerebral,middle,Post-stroke,stroke,inhibit,PHA568487,memory,oxidative,polarization,dysfunction,Nicotinic acetylcholine receptors,occlusion,PHA-568487,neuroinflammation,nicotinic,artery,stress,nAChR
CBNumber: CB12456358
Molecular Formula: C16H20N2O3
Formula Weight: 288.34
MOL File: 527680-56-4.mol

More

Less

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE Property

storage temp.: Desiccate at RT
solubility: <40.44mg/ml in Water; <40.44mg/ml in DMSO
form: Solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Tocris

Product number: 3134
Product name: PHA568487
Purity: ≥99%(HPLC)
Packaging: 10
Price: $173
Updated: 2021/12/16

Tocris

Product number: 3134
Product name: PHA568487
Purity: ≥99%(HPLC)
Packaging: 50
Price: $742
Updated: 2021/12/16

TRC

Product number: P294493
Product name: PHA568487
Packaging: 25mg
Price: $230
Updated: 2021/12/16

Usbiological

Product number: 462342
Product name: PHA 568487
Packaging: 10mg
Price: $403
Updated: 2021/12/16

Usbiological

Product number: 256227
Product name: PHA 568487
Packaging: 10mg
Price: $409
Updated: 2021/12/16

More

Less

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE Chemical Properties,Usage,Production

Uses

PHA 568487 is an agonist of AChR α7.

in vivo

PHA 568487 treatment reduces mouse cognitive decline caused by aseptic bone fracture by promoting inflammation resolution. PHA 568487 (PHA; 0.8 mg/kg; injected intraperitoneally) reduces infarct volume and TUNEL positive neurons in the peri-infarct regions of permanent middle cerebral artery occlusion (pMCAO) and pMCAO+tibia fracture mice^[2].
The role played by a7 receptors on neuroinflammation is supported by the decrease of [¹⁸F]DPA-714 binding in ischemic rats treated with the a7 agonist PHA 568487 at day 7 after MCAO^[3].
PHA 568487-treated ischemic rats show a significant reduction of the cerebral infarct volumes and an improvement of the neurologic outcome compared with non-treated MCAO rats^[3].

Animal Model:	C57BL/6J male mice (10-12 weeks old) with pMCAO^[2]
Dosage:	0.4 and 0.8 mg/kg
Administration:	Injected intraperitoneally once on day 1, or twice on days 1 and 2, after pMCAO
Result:	0.8 mg/kg on days 1 and 2 after pMCAO yielded the best effect on infarct volume and behavior tests.

Animal Model:	Adult male Sprague-Dawley rats^[3]
Dosage:	1.25 mg/kg
Administration:	Treated i.p. daily with 0.1 mL
Result:	Showed a significant decrease of [18F]DPA-714 binding in the ischemic cerebral hemisphere in comparison to non-treated ischemic rats.

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE Suppliers

China 25 United Kingdom 1 United States 3 Global 29

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4798
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62220
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

527680-56-4, N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATERelated Search:

N-(3R)-1-AZABICYCLO[2.2.2]OCT-3-YL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-CARBOXAMIDE FUMARATE

PHA 568487

1,4-Benzodioxin-6-carboxamide, N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-2,3-dihydro-

PH-568487

PHA 568487 free base

macrophage,fracture,acetylcholine,Inhibitor,ischemic,bone,receptor,PHA 568487 free base,cerebral,middle,Post-stroke,stroke,inhibit,PHA568487,memory,oxidative,polarization,dysfunction,Nicotinic acetylcholine receptors,occlusion,PHA-568487,neuroinflammation,nicotinic,artery,stress,nAChR

(R)-N-(Quinuclidin-3-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide

527680-56-4

C16H20N2O3C4H4O4