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1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE

Aroma
Product Name
1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE
CAS No.
943-88-4
Chemical Name
1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE
Synonyms
NSC31752;AI3-00222;NSC-31752;NSC 31752;ANISALACETONE;p-Anisalacetone;anisylideneacetone;Ani-sylideneacetone;p-Anisilidenacetone;p-Anisylideneacetone
CBNumber
CB1245673
Molecular Formula
C11H12O2
Formula Weight
176.21
MOL File
943-88-4.mol
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1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Property

Melting point:
75-77°
Boiling point:
267.83°C (rough estimate)
Density 
1.0558 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Very Slightly)
form 
Solid
color 
White or yellowish leafy crystals.
LogP
2.25
EPA Substance Registry System
3-Buten-2-one, 4-(4-methoxyphenyl)- (943-88-4)
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Safety

HazardClass 
IRRITANT
HS Code 
2914500090
Toxicity
Both the acute oral LD50 value in rats and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Wohl, 1974).
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M226670
Product name
4-(4-Methoxyphenyl)-3-buten-2-one
Packaging
5g
Price
$720
Updated
2021/12/16
Matrix Scientific
Product number
043222
Product name
4-(4-Methoxyphenyl)-3-buten-2-one
Purity
>95%
Packaging
500mg
Price
$53
Updated
2021/12/16
Matrix Scientific
Product number
043222
Product name
4-(4-Methoxyphenyl)-3-buten-2-one
Purity
>95%
Packaging
1g
Price
$82
Updated
2021/12/16
SynQuest Laboratories
Product number
2917-1-44
Product name
4-(4-Methoxyphenyl)but-3-en-2-one
Packaging
1g
Price
$109
Updated
2021/12/16
Apolloscientific
Product number
OR26402
Product name
4-(4-Methoxyphenyl)but-3-en-2-one
Packaging
1g
Price
$144
Updated
2021/12/16
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1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Chemical Properties,Usage,Production

Aroma

Slightly pungent, but in dilution sweet, floral and creamy odor of considerable tenacity. 
1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE, like many related ketones, has met with much resistance from perfumers and dermatologists. However, it has survived all attacks under the usual and probably reasonable argument, that in normal concentrations, it will have no harmful effects on the human skin. Undoubtedly, perfumers are using scores of materials with a much shorter history of successful application.
It finds use in many floral perfume compositions, mainly Cassie bases, Acacia, Lilac, Sweet Pea, Hyacinth, etc. In even lower concentration, it may give interesting effects in Lavender, Fougeres, New Mown Hay (for which it was originally intended), etc.

Occurrence

Has apparently not been reported to occur in nature.

Uses

4-(4-methoxyphenyl)-3-buten-2-one is used in preparation of Thiazole derivatives as protein secretion inhibitors.

Preparation

From anisaldehyde and acetone by condensation using a suitable catalyst.

Metabolism

When the side chain of a mixed ketone contains a double bond, both the keto group and the double bond are potentially reducible in vivo. In a related material, methyl styryl ketone ( C6 H5 CH:CHCOCH3 ) , the keto group appears to be more readily reduced than the double bond,with reduction via C6 H5 CH:CH.CH(OH)CH3to the completely reduced carbinol compoundC6 H5[CH2]2CH(OH) CH3, which is found as the main product (Fischer & Bielig, 1940). The ether link is relatively stable in substituted anisoles, such as anethole (p-CH3OC 6H4CH:CH CH4), containinga potential carboxyl group attached to the aromatic ring (Williams, 1959).

1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE Suppliers

China 36 Germany 1 India 1 United Kingdom 1 United States 7 USA 1 Global 47
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88
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View Lastest Price from 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Dobutamine Impurity 25 943-88-4
Price
US $0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-03-28
Shaanxi Dideu Medichem Co. Ltd
Product
1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE 943-88-4
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2024-08-28

943-88-4, 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONERelated Search:

1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE,4-(4-METHOXYPHENYL)-3-BUTEN-2-ONE,4-(P-METHOXYPHENYL)-3-BUTEN-2-ONE Vanillylidenacetone Benzylacetone 3-methyl-4-(4-methoxyphenyl)-3-buten-2-one trans-4-(4-Methoxyphenyl)-3-buten-2-one 3-METHOXYBENZALACETONE 3,4-Bis(p-methoxyphenyl)-3-buten-2-one (2Z)-1,3-Bis(4-methoxyphenyl)-2-buten-1-one 3-(4-methoxyanilino)-1-(4-methoxyphenyl)-2-buten-1-one 4-(m-Methoxyphenyl)-3-buten-2-one semicarbazone (E)-1-(4-Methoxyphenyl)-2-buten-1-one 1-(1,3-Dithian-2-ylidene)-4-(4-methoxyphenyl)-3-buten-2-one 4-(o-Methoxyphenyl)-3-buten-2-one semicarbazone 4-(2-HYDROXY-3-METHOXYPHENYL)-3-BUTEN-2-ONE 1-(1,3-Dithiolan-2-ylidene)-4-(4-methoxyphenyl)-3-buten-2-one 4-(p-Methoxyphenyl)-3-buten-2-one semicarbazone 2-METHOXYBENZALACETONE (Z)-3-(DIMETHYLAMINO)-1-(4-METHOXYPHENYL)-2-BUTEN-1-ONE

  • (3E)-4-(4-Methoxyphenyl)-3-buten-2-one
  • 4-Methoxystyrylmethyl ketone
  • Methoxybenzalacetone
  • p-Anisylideneacetone
  • 4-(4-methoxyphenyl)-3-buten-2-one (en)
  • 4-Methoxybenzalacetone
  • 4'-Methoxybenzylideneacetone
  • 4-Methoxybenzylideneacetone
  • anisylideneacetone
  • 4-(P-METHOXYPHENYL)-3-BUTEN-2-ONE
  • 4-(4-METHOXYPHENYL)-3-BUTEN-2-ONE
  • 4-(4-METHOXY-PHENYL)-BUT-3-EN-2-ONE
  • 1(4-Methoxyphenyl)-but-1-en-3-on
  • 1-(4-Methoxyphenyl)-but-1-en-3-one
  • 3-Buten-2-one, 4-(p-methoxyphenyl)-
  • 4-(4-methoxyphenyl)-3-buten-2-on
  • ANISALACETONE
  • 3-Buten-2-one, 4-(4-methoxyphenyl)-
  • AI3-00222
  • 4-(P-METHOXYPHENYL)-3-BUTEN-2-ONE 98%
  • Ani-sylideneacetone
  • Methyl p-methoxystyryl ketone
  • methyl-p-methoxycinnamylketone
  • methylp-methoxystyrylketone
  • p-Anisalacetone
  • p-Anisilidenacetone
  • p-Methoxybenzalacetone
  • p-Methoxybenzylideneacetone
  • p-methoxystyrylmethylketone
  • 1-(P-METHOXYPHENYL)-1-BUTEN-3-ONE
  • 4-(p-Methoxyphenyl)-3-butene-2-one@1000 μg/mL in AcCN
  • NSC31752
  • NSC-31752
  • NSC 31752
  • Dobutamine Impurity 25
  • Chlorobutanol Impurity?5 (S 421)
  • 943-88-4
  • CH3OC6H4CHCHCOCH3