ChemicalBook > CAS DataBase List > RO 0437626
RO 0437626
- Product Name
- RO 0437626
- CAS No.
- 134362-79-1
- Chemical Name
- RO 0437626
- Synonyms
- RO 0437626;N-[(1R)-2-[[(1S,2R,3S)-1-(Cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-1H-benzimidazole-2-carboxamide;1H-Benzimidazole-2-carboxamide, N-[(1R)-2-[[(1S,2R,3S)-1-(cyclohexylmethyl)-3-cyclopropyl-2,3-dihydroxypropyl]amino]-2-oxo-1-(4-thiazolylmethyl)ethyl]-
- CBNumber
- CB12458150
- Molecular Formula
- C27H35N5O4S
- Formula Weight
- 525.66
- MOL File
- 134362-79-1.mol
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RO 0437626 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Powder
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N-Bromosuccinimide Price
Tocris
- Product number
- 2188
- Product name
- Ro0437626
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $252
- Updated
- 2021/12/16
Tocris
- Product number
- 2188
- Product name
- Ro0437626
- Purity
- ≥98%(HPLC)
- Packaging
- 1
- Price
- $120
- Updated
- 2021/12/16
TRC
- Product number
- R700888
- Product name
- Ro0437626
- Packaging
- 1mg
- Price
- $165
- Updated
- 2021/12/16
Usbiological
- Product number
- 256471
- Product name
- Ro 0437626
- Packaging
- 1mg
- Price
- $403
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B6964
- Product name
- Ro0437626
- Packaging
- 10mg
- Price
- $497
- Updated
- 2021/12/16
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RO 0437626 Chemical Properties,Usage,Production
Uses
Ro 0437626 is a P2X1 purinergic receptor antagonist.
Biological Activity
Selective P2X 1 purinergic receptor antagonist (IC 50 = 3 μ M) that displays > 30-fold selectivity over P2X 2 , P2X 3 and P2X 2/3 receptors (IC 50 > 100 μ M).
in vivo
Ro 0437626 (1 and 10 μmol/kg; i.v.) causes a reduction in postinfusion isovolumetric contractions[3].
| Animal Model: | Female rat (urethane-anaesthetized)[3] |
| Dosage: | 1 and 10 μmol/kg |
| Administration: | I.v. |
| Result: | Caused a reduction in postinfusion isovolumetric contractions. |
RO 0437626 Preparation Products And Raw materials
Raw materials
Preparation Products
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