4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER
- Product Name
- 4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER
- CAS No.
- 166272-81-7
- Chemical Name
- 4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER
- Synonyms
- 4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 4-chloro-3-hydroxy-, methyl ester
- CBNumber
- CB12458352
- Molecular Formula
- C8H7ClO3
- Formula Weight
- 186.59
- MOL File
- 166272-81-7.mol
4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER Property
- Melting point:
- 100-101 °C
- Boiling point:
- 288.3±20.0 °C(Predicted)
- Density
- 1.354±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 7.68±0.10(Predicted)
- Appearance
- Light brown to brown Solid
Safety
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C366705
- Product name
- 4-Chloro-3-hydroxybenzoicAcidMethylEster
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- FC76172
- Product name
- 4-Chloro-3-hydroxybenzoic acid methyl ester
- Packaging
- 2g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FC76172
- Product name
- 4-Chloro-3-hydroxybenzoic acid methyl ester
- Packaging
- 5G
- Price
- $112.5
- Updated
- 2021/12/16
- Product number
- 083305
- Product name
- Methyl 4-chloro-3-hydroxybenzoate
- Purity
- 97%
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
- Product number
- Z4261
- Product name
- Methyl4-chloro-3-hydroxybenzoate
- Packaging
- 2g
- Price
- $131
- Updated
- 2021/12/16
4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production
Uses
4-Chloro-3-hydroxybenzoic Acid Methyl Ester id used in the synthesis of antidepressants.
Synthesis
67-56-1
34113-69-4
166272-81-7
The general procedure for the synthesis of methyl 3-hydroxy-4-chlorobenzoate from methanol and 4-chloro-3-hydroxybenzoic acid was as follows: thionyl chloride (6 g) was added slowly and dropwise to a methanol (100 mL) solution of 4-chloro-3-hydroxybenzoic acid (4.4 g, 25.50 mmol). The reaction mixture was stirred at 70 °C for 2 hours. Upon completion of the reaction, the reaction solution was concentrated under reduced pressure to remove the solvent. The concentrated residue was diluted by adding hexane (50 mL) to the concentrated residue. The precipitated solid product was collected by filtration and dried in an oven under reduced pressure to afford methyl 3-hydroxy-4-chlorobenzoate as a light yellow solid (4 g, 84% yield). The product was analyzed by LC/MS (electrospray ionization, m/z): [M+H]+ 187.0. 1H NMR (300 MHz, DMSO-d6) δ 10.69 (s, 1H, OH), 7.55 (d, J=2.10 Hz, 1H, ArH), 7.49 (d, J=8.40 Hz, 1H, ArH), 7.36-7.40 ( m, 1H, ArH), 3.83-3.85 (d, J=8.40Hz, 3H, OCH3).
References
[1] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 11, p. 2365 - 2369
[2] Patent: WO2014/66795, 2014, A1. Location in patent: Paragraph 0175
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 3141 - 3147
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 9, p. 3290 - 3312
[5] Patent: EP2048140, 2009, A1. Location in patent: Page/Page column 25
4-CHLORO-3-HYDROXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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