(5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER
- Product Name
- (5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER
- CAS No.
- 227939-01-7
- Chemical Name
- (5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER
- Synonyms
- tert-Butyl (5-bromopyridin-2-yl);N-Boc-N-methyl-5-bromo-2-pyridinamine;2-(N-BOC-N-methylamino)-5-bromopyridine;ert-butylN-(5-bromopyridin-2-yl)-N-methylcarbamate;(5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER;Carbamic acid, (5-bromo-2-pyridinyl)methyl-, 1,1-dimethylethyl ester;Carbamic acid, N-(5-bromo-2-pyridinyl)-N-methyl-, 1,1-dimethylethyl ester;(5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER ISO 9001：2015 REACH
- CBNumber
- CB12459157
- Molecular Formula
- C11H15BrN2O2
- Formula Weight
- 287.15
- MOL File
- 227939-01-7.mol
(5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER Property
- Boiling point:
- 338.5±27.0 °C(Predicted)
- Density
- 1.391±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.15±0.10(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- B600748
- Product name
- 2-(N-BOC-N-methylamino)-5-bromopyridine
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 073005
- Product name
- (5-Bromopyridin-2-yl)methyl-carbamic acidtert-butyl ester
- Purity
- 95+%
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- FB153618
- Product name
- (5-Bromopyridin-2-yl)methyl-carbamic acid tert-butyl ester
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 073005
- Product name
- (5-Bromopyridin-2-yl)methyl-carbamic acidtert-butyl ester
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $42
- Updated
- 2021/12/16
- Product number
- 073005
- Product name
- (5-Bromopyridin-2-yl)methyl-carbamic acidtert-butyl ester
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $64
- Updated
- 2021/12/16
(5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER Chemical Properties,Usage,Production
Synthesis
84539-30-0
24424-99-5
227939-01-7
General procedure: 5-bromo-2-(methylamino)pyridine (2.0 g, 10.7 mmol) and di-tert-butyl dicarbonate (2.8 g, 12.8 mmol, 3.0 mL) were dissolved in tetrahydrofuran (20 mL) under nitrogen protection and cooled to 0 °C. NaHMDS (1 M, 12 mL) was added slowly, keeping the reaction temperature at 0 °C. After addition, the reaction mixture was gradually warmed to 20 °C and stirred continuously for 13 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: petroleum ether/ethyl acetate = 3/1) and a small amount of raw material residue and a new point of lower polarity (product point) were observed. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution (30 mL) and extracted with ethyl acetate (50 mL × 2). The organic phases were combined, washed with saturated saline (30 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10/1~3/1) to afford 5-bromo-2-(N-methyl-N-(tert-butoxycarbonyl)amino)pyridine (2.8 g, 91% yield) as a light yellow liquid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3) and ESI-MS: 1H NMR δ 8.40-8.39 (m, 1H), 7.71-7.65 (m, 2H), 3.37 (s, 3H), 1.49 (s, 9H); ESI-MS (m/z): 287.0 ([M+H]+).
References
[1] Patent: WO2017/120429, 2017, A1. Location in patent: Page/Page column 261
[2] Patent: WO2007/86800, 2007, A1. Location in patent: Page/Page column 94
[3] Patent: CN104292242, 2017, B. Location in patent: Paragraph 0105; 0115
(5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER manufacturers
- Product
- (5-BROMOPYRIDIN-2-YL)METHYL-CARBAMIC ACID TERT-BUTYL ESTER 227939-01-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-24
- Product
- 2-(N-BOC-N-MethylaMino)-5-broMopyridine 227939-01-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-12