ChemicalBook > CAS DataBase List > 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- Product Name
- 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- CAS No.
- 81971-38-2
- Chemical Name
- 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- Synonyms
- 3-bromo-1-methylpyridin-2-one;BROMO-1-METHYLPYRIDIN-2(1H)-ONE;3-Bromo-1-methyl-2(1H)-pyridinone;3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE;3-Bromo-1-methyl-1H-pyridin-2-one;2(1H)-Pyridinone, 3-bromo-1-methyl-;3-bromo-1-methyl-1,2-dihydropyridin-2-one
- CBNumber
- CB12459632
- Molecular Formula
- C6H6BrNO
- Formula Weight
- 188.02
- MOL File
- 81971-38-2.mol
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3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Property
- Boiling point:
- 120-125 °C(Press: 0.5 Torr)
- Density
- 1.664±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -2.77±0.62(Predicted)
- Appearance
- Off-white to gray Solid
- InChI
- InChI=1S/C6H6BrNO/c1-8-4-2-3-5(7)6(8)9/h2-4H,1H3
- InChIKey
- HKLQWLOMEUJSOR-UHFFFAOYSA-N
- SMILES
- C1(=O)N(C)C=CC=C1Br
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B681938
- Product name
- 3-Bromo-1-methylpyridin-2(1H)-one
- Packaging
- 100mg
- Price
- $155
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0620623
- Product name
- 3-BROMO-1-METHYL-1,2-DIHYDROPYRIDIN-2-ONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $454.9
- Updated
- 2021/12/16
AK Scientific
- Product number
- 3240AQ
- Product name
- 3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
- Packaging
- 1g
- Price
- $726.8
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 123121
- Product name
- 3-Bromo-1-methylpyridin-2(1H)-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1238
- Updated
- 2021/12/16
Chemenu
- Product number
- CM255152
- Product name
- 3-Bromo-1-methylpyridin-2(1H)-one
- Purity
- 95%
- Packaging
- 25g
- Price
- $1683
- Updated
- 2021/12/16
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3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Chemical Properties,Usage,Production
Synthesis
13466-43-8
74-88-4
81971-38-2
Example 19: A mixture of 3-bromo-2-hydroxypyridine (740 mg, 4.25 mmol), potassium carbonate (1.18 g, 8.5 mmol), and iodomethane (2.65 mL, 42.5 mmol) in 1,2-dimethoxyethane (DME, 10 mL) was heated to reflux, and the reaction was carried out overnight. Upon completion of the reaction, the mixture was filtered and the solids were washed with ethyl acetate. The filtrate and washings were combined and concentrated to dryness under reduced pressure. The resulting crude product was purified by dry column chromatography on silica gel (27 g) to afford the target compound 3-bromo-1-methyl-2-pyridinone (0.63 g, 79% yield) using ethyl acetate as eluent. The product was detected by low resolution mass spectrometry (LRMS, electrospray ionization, positive ion mode) and showed a molecular ion peak m/z 188 ([M + H]+).
References
[1] Synlett, 2015, vol. 26, # 11, p. 1557 - 1562
[2] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 23, p. 7076 - 7080
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 4840 - 4860
[4] Patent: US6388084, 2002, B1
[5] Patent: WO2017/197046, 2017, A1. Location in patent: Page/Page column 344; 345
3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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3-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Suppliers
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