5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE
- Product Name
- 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE
- CAS No.
- 873107-98-3
- Chemical Name
- 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE
- Synonyms
- 5-Iodo-2-(trifluoromethyl);5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE;Pyridine, 5-iodo-2-(trifluoromethyl)-;5-Iodo-2-(trifluoromethyl)pyridine 95+%
- CBNumber
- CB12465046
- Molecular Formula
- C6H3F3IN
- Formula Weight
- 272.99
- MOL File
- 873107-98-3.mol
5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE Property
- Melting point:
- 74-77°
- Boiling point:
- 203.7±40.0 °C(Predicted)
- Density
- 1.974±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -1.47±0.22(Predicted)
- form
- solid
- color
- White
- InChI
- InChI=1S/C6H3F3IN/c7-6(8,9)5-2-1-4(10)3-11-5/h1-3H
- InChIKey
- GBAXFWLQMVBNMV-UHFFFAOYSA-N
- SMILES
- C1(C(F)(F)F)=NC=C(I)C=C1
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I724830
- Product name
- 5-Iodo-2-(trifluoromethyl)pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 3H32-K-21
- Product name
- 5-Iodo-2-(trifluoromethyl)pyridine
- Packaging
- 5G
- Price
- $1143
- Updated
- 2021/12/16
- Product number
- 3812AC
- Product name
- 5-Iodo-2-(trifluoromethyl)pyridine
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 066774
- Product name
- 5-Iodo-2-(trifluoromethyl)pyridine
- Packaging
- 500mg
- Price
- $145
- Updated
- 2021/12/16
- Product number
- PC409520
- Product name
- 5-Iodo-2-(trifluoromethyl)pyridine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $198
- Updated
- 2021/12/16
5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE Chemical Properties,Usage,Production
Uses
5-Iodo-2-(trifluoromethyl)pyridine is a useful reactant for metal-catalyzed organic reactions.
Synthesis
106877-33-2
873107-98-3
Step 1: Synthesis of 5-iodo-2-(trifluoromethyl)pyridine 6-(Trifluoromethyl)pyridin-3-amine (9.96 g, 0.062 mol) was dissolved in 5N HCl (70 mL) and cooled to -5 °C. A 30 mL aqueous solution of sodium nitrite (6.39 g, 0.093 mol) was slowly added dropwise while keeping the internal temperature below 5 °C. After the dropwise addition, the reaction was continued at -5 °C for 10 min. Subsequently, a 30 mL aqueous solution of KI (22.5 g, 0.136 mol) was added slowly dropwise while keeping the internal temperature below 10 °C. After completion of the dropwise addition, the reaction mixture was gradually warmed up to room temperature. Extraction was carried out by adding 250 mL of EtOAc, and the pH of the aqueous layer was adjusted to 11 by adding 50 mL of 6N NaOH. the organic and aqueous layers were separated, and the organic layer was washed with 120 mL of 0.3 M Na2S2O3 solution. The EtOAc layer was concentrated and the resulting concentrate was purified by silica gel column chromatography (eluent: hexane/EtOAc = 25/1) to give the title compound as a white solid (14.6 g, 87% yield). MS (ESI) calculated value: C6H3F3IN [M]+: 273.0; measured value: 274.0 [M+H]+. 1H NMR (400 MHz, CDCl3) δ 8.96 (s, 1H), 8.22 (d, J = 8.2 Hz, 1H), 7.47 (d, J = 8.2 Hz, 1H).
References
[1] Patent: WO2015/187845, 2015, A1. Location in patent: Paragraph 0251
[2] Patent: WO2016/44323, 2016, A1. Location in patent: Paragraph 0347
[3] Patent: WO2006/4533, 2006, A1. Location in patent: Page/Page column 25
5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE Preparation Products And Raw materials
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View Lastest Price from 5-IODO-2-(TRIFLUOROMETHYL)PYRIDINE manufacturers
- Product
- 5-Iodo-2-(trifluoromethyl)pyridine 873107-98-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-02-05