CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO-
- Product Name
- CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO-
- CAS No.
- 922728-21-0
- Chemical Name
- CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO-
- Synonyms
- 158106;4,4-DIFLUOROCYCLOHEXANECARBONITRILE;4,4-difluorocyclohexane-1-carbonitrile;CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO-;4,4-difluoro-1-cyclohexanecarbonitrile
- CBNumber
- CB12466331
- Molecular Formula
- C7H9F2N
- Formula Weight
- 145.15
- MOL File
- 922728-21-0.mol
CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO- Property
- Boiling point:
- 204.4±40.0 °C(Predicted)
- Density
- 1.10±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P322Specific measures (see …on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AS44882
- Product name
- 4,4-Difluorocyclohexanecarbonitrile
- Purity
- 95+%
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- AS44882
- Product name
- 4,4-Difluorocyclohexanecarbonitrile
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $269
- Updated
- 2021/12/16
- Product number
- HCH0044847
- Product name
- 4,4-DIFLUOROCYCLOHEXANECARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.46
- Updated
- 2021/12/16
- Product number
- AS44882
- Product name
- 4,4-Difluorocyclohexanecarbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $549
- Updated
- 2021/12/16
- Product number
- 5588AC
- Product name
- 4,4-Difluorocyclohexanecarbonitrile
- Packaging
- 1g
- Price
- $681
- Updated
- 2021/12/16
CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO- Chemical Properties,Usage,Production
Synthesis
34916-10-4
922728-21-0
459-53-0
General procedure for the synthesis of 4,4-difluorocyclohexanecarbonitrile and 4-fluorocyclohex-3-ene-1-carbonitrile from 4-oxocyclohexanecarbonitrile: A solution of (diethylamino)sulfur trifluoride (46.7 g, 289 mmol) in dichloromethane (200 mL) was added slowly and dropwise at 0 °C to a solution of 4-oxocyclohexanecarbonitrile (32.4 g, 263 mmol) in dichloromethane ( 400 mL) solution. The reaction mixture was stirred at this temperature for 2 hours and then the reaction was quenched with deionized water (100 mL). The organic phase was separated and dried over anhydrous magnesium sulfate. After concentrating the solvent, a 7:3 mixture of 4,4-difluorocyclohexanecarbonitrile and 4-fluorocyclohex-3-ene-1-carbonitrile was obtained. Another 77% m-chloroperoxybenzoic acid (MCPBA, 45 g, 200 mmol) was stirred in chloroform (600 mL) for 30 min and the solution was dried over anhydrous sodium sulfate and filtered. A mixture of 4,4-difluorocyclohexanecarbonitrile and 4-fluorocyclohex-3-ene-1-carbonitrile obtained above was added to the MCPBA solution and stirred at room temperature for 18 hours. After completion of the reaction, the reaction mixture was washed with 1.5 M sodium hydroxide solution (3 x 300 mL) and the organic phase was dried with anhydrous magnesium sulfate. After concentrating the solvent, the residue was distilled under reduced pressure to give the pure target compound 4,4-difluorocyclohexanecarbonitrile as a colorless liquid. Yield 18.2 g (47%).1H NMR (400 MHz, chloroform-d) δ 1.86-1.96 (m, 1H), 1.95-2.03 (m, 5H), 2.03-2.22 (m, 2H), 2.68-2.85 (m, 1H).
References
[1] Patent: WO2007/13848, 2007, A1. Location in patent: Page/Page column 9
CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO- manufacturers
- Product
- CYCLOHEXANECARBONITRILE, 4,4-DIFLUORO- 922728-21-0
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-29