1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO-

Uses

Product Name: 1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO-
CAS No.: 141106-23-2
Chemical Name: 1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO-
Synonyms: 8-bromo-3,4-dihydro-2H-1-benzoxepin-5-one;8-Bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one;8-bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one;1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO-;8-Bromo-2,3,4,5-tetrahydro-1-benzoxepin-5-one
CBNumber: CB12467712
Molecular Formula: C10H9BrO2
Formula Weight: 241.08
MOL File: 141106-23-2.mol

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1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO- Property

Boiling point:: 349.0±41.0 °C(Predicted)
Density: 1.528±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
Appearance: Colorless to off-white <38°C Solid,>40°C Liquid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T325880
Product name: 8-BROMO-3,4-DIHYDRO-1-BENZOXEPIN-5(2H)-ONE
Purity: Aldrich<sup>CPR</sup>
Packaging: 1 unit
Price: $148
Updated: 2025/07/31

Sigma-Aldrich

Product number: T325880
Product name: 8-BROMO-3,4-DIHYDRO-1-BENZOXEPIN-5(2H)-ONE
Purity: AldrichCPR
Packaging: 1MG
Price: $144
Updated: 2024/03/01

TRC

Product number: B999035
Product name: 8-Bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB161348
Product name: 8-Bromo-2,3,4,5-tetrahydro-1-benzoxepin-5-one
Packaging: 2g
Price: $700
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0061268
Product name: 8-BROMO-3,4-DIHYDRO-1-BENZOXEPIN-5(2H)-ONE
Purity: 95.00%
Packaging: 1G
Price: $852.55
Updated: 2021/12/16

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1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO- Chemical Properties,Usage,Production

Uses

8-Bromo-3,4-dihydrobenzo[b]oxepin-5(2H)-one is a useful research chemical.

Synthesis

170638-88-7

141106-23-2

General procedure for the synthesis of 8-bromo-3,4-dihydro-2H-benzo[B]oxoheptatrien-5-one from 4-(3-bromophenoxy)butyric acid: a mixture of polyphosphoric acid (590 g), diatomaceous earth (400 g) and toluene (1.5 L) was stirred for 0.5 h under nitrogen protection. Subsequently, 4-(3-bromophenoxy)butyric acid (135.8 g, 0.5264 mol) was added to the mixture. The reaction mixture was refluxed for 2.5 hours and then cooled to room temperature. The reaction mixture was filtered and the diatomaceous earth/polyphosphoric acid residue was washed with ethyl acetate (1.5 L). The organic phase was washed sequentially with 1N sodium hydroxide solution (3 x 0.75 L), water (1 L) and saturated saline, and then dried over anhydrous sodium sulfate. Concentration of the combined organic layers afforded 94.3 g (75% yield) of 8-bromo-3,4-dihydro-2H-benzo[b]oxepinacotrien-5-one. This product was combined with 85.0 g of 8-bromo-3,4-dihydro-2H-benzo[b]oxepinacotrien-5-one (total weight 173.3 g) from other experiments and distilled using a Kugelrohr apparatus (oven temperature 130 ± 5°C) to give a final 158.4 g of 8-bromo-3,4-dihydro-2H-benzo[b]oxepinacotrien-5-one , boiling point: 38.8-39.0°C (0.20 mmHg), melting point: 38.4-38.5°C. The final product is a mixture of the following substances.

References

[1] Patent: WO2004/69245, 2004, A1. Location in patent: Page/Page column 89
[2] Patent: US2012/238549, 2012, A1. Location in patent: Page/Page column 127
[3] European Journal of Medicinal Chemistry, 1995, vol. 30, # 5, p. 377 - 386
[4] Patent: WO2015/89337, 2015, A1. Location in patent: Paragraph 0515; 0527
[5] Patent: WO2018/191577, 2018, A1. Location in patent: Page/Page column 142

1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO- Preparation Products And Raw materials

Raw materials

Preparation Products

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1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO- Suppliers

China 46 India 1 United Kingdom 1 United States 2 Global 50

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Suzhou Devi Pharma Technology Co., Ltd.

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View Lastest Price from 1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO- manufacturers

Career Henan Chemica Co

Product: 1-BENZOXEPIN-5(2H)-ONE, 8-BROMO-3,4-DIHYDRO- 141106-23-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: MIn98%HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-29

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