ChemicalBook > CAS DataBase List > BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER

BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER

Product Name
BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER
CAS No.
199328-35-3
Chemical Name
BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER
Synonyms
Ethyl 2-(4-bromo-2-nitrophenyl);ethyl 4-bromo-2-nitrophenylacetate;2-(4-bromo-2-nitrophenyl)acetic acid ethyl ester;(4-Bromo-2-nitro-phenyl)-acetic acid ethyl ester;BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER
CBNumber
CB12467929
Molecular Formula
C10H10BrNO4
Formula Weight
288.09
MOL File
199328-35-3.mol
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BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER Property

Boiling point:
345℃
Density 
1.542
Flash point:
163℃
storage temp. 
Sealed in dry,Room Temperature
Appearance
Brown to orange Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
Z4371
Product name
Ethyl2-(4-bromo-2-nitrophenyl)acetate
Packaging
1g
Price
$172
Updated
2021/12/16
Matrix Scientific
Product number
126662
Product name
Ethyl2-(4-bromo-2-nitrophenyl)acetate
Purity
>95%
Packaging
1g
Price
$450
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0368710
Product name
ETHYL-2-(4-BROMO-2-NITROPHENYL)ACETATE
Purity
95.00%
Packaging
5MG
Price
$496.56
Updated
2021/12/16
Ambeed
Product number
A238474
Product name
Ethyl2-(4-bromo-2-nitrophenyl)acetate
Purity
98%
Packaging
250mg
Price
$30
Updated
2021/12/16
Advanced Chemicals Intermediatesced Chemicals Intermediates
Product number
ACI-06401
Product name
(4-Bromo-2-nitro-phenyl)-aceticacidethylester
Purity
95%+
Packaging
250mg
Price
$37.7
Updated
2021/12/16
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BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER Chemical Properties,Usage,Production

Synthesis

64-17-5

6127-11-3

199328-35-3

General procedure for the synthesis of ethyl 4-bromo-2-nitrophenylacetate from ethanol and 2-(4-bromo-2-nitrophenyl)acetic acid: to a solution of 2-(4-bromo-2-nitrophenyl)acetic acid (7.00 g, 27.0 mmol) in ethanol (60 mL) was slowly added concentrated sulfuric acid (1 mL). The reaction mixture was heated to reflux and maintained for 2 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure. The concentrated residue was dissolved in ethyl acetate (250 mL) and separated by extraction with saturated sodium carbonate solution (50 mL). The organic layer was washed sequentially with saturated sodium carbonate solution (50 mL) and brine (50 mL). The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give ethyl 4-bromo-2-nitrophenylacetate (8.00 g, 98% yield) as an ester liquid.

References

[1] Patent: WO2005/63767, 2005, A2. Location in patent: Page/Page column 44
[2] Patent: US2007/78147, 2007, A1. Location in patent: Page/Page column 72
[3] Patent: WO2008/73480, 2008, A1. Location in patent: Page/Page column 27; 28
[4] ACS Medicinal Chemistry Letters, 2012, vol. 3, # 2, p. 140 - 145
[5] Patent: WO2006/52936, 2006, A2. Location in patent: Page/Page column 48

BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZENEACETIC ACID, 4-BROMO-2-NITRO-, ETHYL ESTER Suppliers

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