ChemicalBook > CAS DataBase List > （2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine

（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine

Product Name
（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine
CAS No.
13500-53-3
Chemical Name
（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine
Synonyms
(2S,4R)-Dibenzyl 4-hydroxypyrrolidine-1,2-dicarboxylate;（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine;dibenzyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;DIBENZYL (2S,4R)-4-HYDROXY-1,2-PYRROLIDINEDICARBOXYLATE;N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester;1,2-dibenzyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;(2S,4R)-4-hydroxy-1,2-Pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester;1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1,2-bis(phenylmethyl) ester, (2S,4R)-
CBNumber
CB12469882
Molecular Formula
C20H21NO5
Formula Weight
355.38
MOL File
13500-53-3.mol
More
Less

（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine Property

storage temp. 
2-8°C
Appearance
Colorless to light yellow Viscous Liquid
More
Less

Safety

HazardClass 
IRRITANT
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
CCH0001436
Product name
(2S,4R)-1,2-DICARBOBENZYLOXY-4-HYDROXYPYRROLIDINE
Purity
95.00%
Packaging
250MG
Price
$204.75
Updated
2021/12/16
Matrix Scientific
Product number
057252
Product name
(2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine
Purity
98%
Packaging
1g
Price
$292
Updated
2021/12/16
AK Scientific
Product number
X6459
Product name
(2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine
Packaging
1g
Price
$304
Updated
2021/12/16
AK Scientific
Product number
X6459
Product name
(2S,4R)-1,2-Dicarbobenzyloxy-4-hydroxypyrrolidine
Packaging
5g
Price
$791
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0001436
Product name
(2S,4R)-1,2-DICARBOBENZYLOXY-4-HYDROXYPYRROLIDINE
Purity
95.00%
Packaging
1G
Price
$898.59
Updated
2021/12/16
More
Less

（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine Chemical Properties,Usage,Production

Synthesis

100-39-0

13504-85-3

13500-53-3

A solution of triethylamine (15 mmol, 3.98 g) and benzyl bromide (16.5 mmol, 2.82 g) in THF (25 mL) at 0 °C was added to Cbz-L-hydroxyproline. The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was dissolved in 50 mL of dichloromethane and washed sequentially with 1N HCl, water, 5% Na2CO3 solution and water. The organic layer was dried with anhydrous Na2SO4, filtered and the solvent evaporated. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate, 2:1) to afford (2S,4R)-1,2-dibenzyloxycarbonyl-4-hydroxypyrrolidine (Compound 3) as a light yellow oil (2.66 g, 50% yield).

References

[1] Advanced Synthesis and Catalysis, 2008, vol. 350, # 17, p. 2747 - 2760
[2] Journal of Organic Chemistry, 2001, vol. 66, # 3, p. 1038 - 1042
[3] Angewandte Chemie - International Edition, 2007, vol. 46, # 47, p. 9073 - 9077
[4] Synlett, 1999, # 9, p. 1465 - 1467
[5] Tetrahedron, 2008, vol. 64, # 10, p. 2480 - 2488

（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

（2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine Suppliers

China 31 India 1 United States 3 Global 35
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
ChemFuture PharmaTech (Jiangsu) Ltd
Tel
5108538618
Fax
86 510 85386988-8017
Email
suger.wang@chemfuture.com
Country
China
ProdList
832
Advantage
65
Chengdu HappySyn Pharmaceutical Technology Co., Ltd.
Tel
028-85114309 18982182443
Email
yangli@happysyn.com
Country
China
ProdList
2151
Advantage
55
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
SynAsst Chemical.
Tel
021-60343070
Fax
021-35122006
Country
China
ProdList
12740
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chengdu Firster Pharmaceutical Co., Ltd.
Tel
028-87078428 028-87074958
Fax
8772-8116
Email
chengzhenyong@cdfirster.com
Country
China
ProdList
2598
Advantage
60
HangZhou YuHao Chemical Technology Co., Ltd.
Tel
0571-82693216
Fax
0571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
2028
Advantage
58
Shanghai ChuangYan Chemical Technology Co., Ltd.
Tel
021-11111111 11111111111
Fax
qq:546919421
Email
546919421@qq.com
Country
China
ProdList
3521
Advantage
55
Shanghai GaoDao Pharmaceutical Co., Ltd.
Tel
021-15001867143 15001867143
Fax
-
Email
1095570358@qq.com
Country
China
ProdList
909
Advantage
55

13500-53-3, （2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidineRelated Search:


  • （2s，4r）-1，2-dicarbobenzyloxy-4-hydroxypyrrolidine
  • 1,2-dibenzyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
  • (2S,4R)-Dibenzyl 4-hydroxypyrrolidine-1,2-dicarboxylate
  • (2S,4R)-4-hydroxy-1,2-Pyrrolidinedicarboxylic acid 1,2-bis(phenylmethyl) ester
  • 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1,2-bis(phenylmethyl) ester, (2S,4R)-
  • dibenzyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate
  • N-benzyloxycarbonyl-(2S,4R)-4-hydroxyproline benzyl ester
  • DIBENZYL (2S,4R)-4-HYDROXY-1,2-PYRROLIDINEDICARBOXYLATE
  • 13500-53-3