(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid
Uses- Product Name
- (R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid
- CAS No.
- 122225-33-6
- Chemical Name
- (R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid
- Synonyms
- 5-CHLOROMETHYL-3-OXAZOLIDINONE;(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid;(R)-2-Benzylbutanedioic acid 4-tert-butyl ester;1H-Imidazole-4-carboxylicacid,1-(5-bromophenyl)-;Butanedioic acid, 2-(phenylmethyl)-, 4-(1,1-dimethylethyl) ester, (2R)-
- CBNumber
- CB12470529
- Molecular Formula
- C15H20O4
- Formula Weight
- 264.32
- MOL File
- 122225-33-6.mol
(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid Property
- Melting point:
- 57.0-59.8 °C
- Boiling point:
- 400.4±38.0 °C(Predicted)
- Density
- 1.118
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.17±0.10(Predicted)
- Appearance
- white solid
- CAS DataBase Reference
- 122225-33-6
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 309613
- Product name
- (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid
- Packaging
- 100.00mg
- Price
- $128
- Updated
- 2026/05/19
- Product number
- 309613
- Product name
- (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid
- Packaging
- 250.00mg
- Price
- $171
- Updated
- 2026/05/19
- Product number
- 309613
- Product name
- (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid
- Packaging
- 1.00g
- Price
- $422
- Updated
- 2026/05/19
- Product number
- B37342
- Product name
- (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid
- Purity
- 90+%
- Packaging
- 100mg
- Price
- $130
- Updated
- 2026/05/06
- Product number
- B37342
- Product name
- (R)-2-Benzyl-4-(tert-butoxy)-4-oxobutanoic acid
- Purity
- 90+%
- Packaging
- 250mg
- Price
- $180
- Updated
- 2026/05/06
(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid Chemical Properties,Usage,Production
Uses
(R)-2-benzyl-4-tert-butoxy-4-oxobutyric acid is an organic intermediate that can be prepared from maleic anhydride and benzaldehyde through a six-step reaction.
Synthesis
1229380-18-0
122225-33-6
To a solution of tert-butyl (R)-4-methyl-2-benzyl succinate (308 mg, 1.11 mmol) in tetrahydrofuran (THF, 3 mL) was added an aqueous solution (3 mL) of lithium hydroxide (107 mg, 4.44 mmol). The reaction mixture was stirred at room temperature overnight. Completion of the reaction was confirmed by monitoring the progress of the reaction by thin layer chromatography (TLC, unfolding agent: cyclohexane/ethyl acetate = 7/3). The reaction mixture was acidified to pH = 1 with 2 M hydrochloric acid (HCl) and then extracted with dichloromethane (DCM, 2 x 20 mL). The organic layers were combined and the solvent was evaporated after separation by a phase separator. The crude product was purified by fast column chromatography (eluent: cyclohexane/ethyl acetate = 9/1 → 7/3), using the starting eluent as solution loading, to afford (R)-2-benzyl-4-(tert-butoxy)-4-oxobutanoic acid as a colorless oil. Yield: 274 mg (94%), purity > 95%, retention time (rt) = 4.17 min (gradient A), mass spectrum (M + H)+ = 209 (loss of tert-butyl).
References
[1] Patent: WO2010/66682, 2010, A1. Location in patent: Page/Page column 207-208
(R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-2-benzyl-4-tert-butoxy-4-oxobutanoic acid manufacturers
- Product
- (R)-2-Benzylbutanedioic acid 4-tert-butyl ester 122225-33-6
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-05