N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine

Product Name: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine
CAS No.: 136834-20-3
Chemical Name: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine
Synonyms: 2'-F-Bz-A;2'-F-Bz-A;Bz-2'-F-dA;2'-F-Bz-dA;2'-F-Bz-dA;2'-F-dA(Bz);N6-Bz-2'-F-dA;N6-Bz-2'-F-2'-dA;N6-Benzoyl-2'-fluorodeoxyadenosine;N-Benzoyl-2'-deoxy-2'-fluoroadenosine
CBNumber: CB12470675
Molecular Formula: C17H16FN5O4
Formula Weight: 373.34
MOL File: 136834-20-3.mol

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N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine Property

Density: 1.67±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 7.87±0.43(Predicted)
form: Solid
color: White to off-white
InChIKey: HLJZTLWDAQVZBU-YAMOITTJSA-N
SMILES: OC[C@H]1O[C@@H](N2C3C(=C(N=CN=3)NC(=O)C3=CC=CC=C3)N=C2)[C@H](F)[C@@H]1O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B997450
Product name: Bz-2''-F-dA
Packaging: 100mg
Price: $65
Updated: 2021/12/16

TRC

Product number: B997450
Product name: Bz-2''-F-dA
Packaging: 500mg
Price: $240
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB46150
Product name: N6-Benzoyl-2'-deoxy-2'-fluoroadenosine
Packaging: 1g
Price: $250
Updated: 2021/12/16

Biosynth Carbosynth

Product number: NB46150
Product name: N6-Benzoyl-2'-deoxy-2'-fluoroadenosine
Packaging: 2g
Price: $420
Updated: 2021/12/16

Ark Pharm

Product number: P000083618
Product name: Bz-2'-F-dA
Purity: 97%
Packaging: 1g
Price: $478
Updated: 2021/12/16

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N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine Chemical Properties,Usage,Production

Uses

2'-F-Bz-A (N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides[1].

Synthesis

146954-64-5

136834-20-3

The general procedure for the synthesis of N-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamides from the compound (CAS:146954-64-5) is as follows: araadenosine (10) first undergoes a methanosilicate-protected hydroxyl group, followed by a reaction at position N6 Benzoylation reaction was carried out. Next, the methylsilyl protecting group is removed using ammonium hydroxide, and then THP protecting groups are introduced by the reaction to protect the 3'- and 5'-hydroxyl groups. Treatment with dihydropyran (DHP) in the presence of a catalytic amount of p-toluenesulfonic acid (pTsOH) yielded protected araadenosine (11). Subsequently, the remaining 2'-hydroxyl group was reacted with trifluoromethanesulfonic anhydride to convert to trifluoromethanesulfonate, and the intermediate was directly reacted with tetrabutylammonium fluoride (TBAF) without purification for fluoride substitution to give compound 12. removal of the THP protecting group by acid-catalyzed methanolysis gave the protected fluoroadenosine intermediate.13 Next, selective methylsulfonylation was carried out on the 5'-hydroxyl group reaction, followed by reaction with BOC-protected diamine, yielded compound 14.Finally, the benzoyl protection on N6 was removed by aminolysis, followed by acid-catalyzed carbamate cleavage to give the target compound No.1.

References

[1] Philip Dan Cook, et al. Compositions and methods for detecting and modulating rna activity and gene expression. WO1991010671A1.

N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine Preparation Products And Raw materials

Raw materials

Preparation Products

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N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine Suppliers

China 95 India 1 United Kingdom 1 United States 6 Global 103

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View Lastest Price from N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine 136834-20-3
Price: US $0.00-0.00/G
Min. Order: 1G
Purity: 97%
Supply Ability: 2000
Release date: 2025-05-30

Hefei Huana Biomedical Technology Co.,Ltd.

Product: N6-bz-2'-F-dA 136834-20-3
Price: US $0.00/g
Min. Order: 100g
Purity: ≥98%(HPLC)
Supply Ability: 20t
Release date: 2023-03-23

Career Henan Chemical Co

Product: N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine 136834-20-3
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-02-05

136834-20-3, N6-Benzoyl-2'-Fluoro-2'-deoxyadenosineRelated Search:

N6-Benzoyl-2'-Fluoro-2'-deoxyadenosine

Bz-2'-F-dA

Adenosine, N-benzoyl-2'-deoxy-2'-fluoro-

N-Benzoyl-2'-deoxy-2'-fluoroadenosine

N6-Benzoyl-2'-deoxy-2'-fluoroadenosine

N-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

N6-Bz-2'-F-dA

N-[9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]purin-6-yl]benzamide

2'-Deoxy-2'-fluoro-N6-benzoyladenosine

N6-Bz-2'-F-2'-dA

Bz-2'-F-dA/N6-Benzoyl-2'-deoxy-2'-fluoroadenosine

2'-F-dA(Bz)

2'-F-Bz-A

2'-F-Bz-dA

2'-F-Bz-A

N6-Benzoyl-2'-fluorodeoxyadenosine

2'-F-Bz-dA

136834-20-3