2-Amino-5-(4-chlorophenyl)thiazole
- Product Name
- 2-Amino-5-(4-chlorophenyl)thiazole
- CAS No.
- 73040-66-1
- Chemical Name
- 2-Amino-5-(4-chlorophenyl)thiazole
- Synonyms
- 5-(4-Chlorophenyl)thiazol-2-aMine;5-(4-Chlorophenyl)-2-thiazolamine;2-Amino-5-(4-chlorophenyl)thiazole;2-Thiazolamine, 5-(4-chlorophenyl)-;5-(4-chlorophenyl)-1,3-thiazol-2-amine;5-(4-chlorophenyl)-2-amino-1,3-thiazole
- CBNumber
- CB12470938
- Molecular Formula
- C9H7ClN2S
- Formula Weight
- 210.68
- MOL File
- 73040-66-1.mol
2-Amino-5-(4-chlorophenyl)thiazole Property
- Melting point:
- 203-204 ºC
- Boiling point:
- 389.8±17.0 °C(Predicted)
- Density
- 1.389
- storage temp.
- 2-8°C(protect from light)
- pka
- 4.26±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C994920
- Product name
- 5-(4-Chlorophenyl)thiazol-2-amine
- Packaging
- 50mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- Z5075
- Product name
- 5-(4-Chlorophenyl)thiazol-2-amine
- Packaging
- 250mg
- Price
- $123
- Updated
- 2021/12/16
- Product number
- FC141371
- Product name
- 5-(4-Chlorophenyl)thiazol-2-amine
- Packaging
- 250mg
- Price
- $167.5
- Updated
- 2021/12/16
- Product number
- FC141371
- Product name
- 5-(4-Chlorophenyl)thiazol-2-amine
- Packaging
- 100mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- FC141371
- Product name
- 5-(4-Chlorophenyl)thiazol-2-amine
- Packaging
- 500mg
- Price
- $290
- Updated
- 2021/12/16
2-Amino-5-(4-chlorophenyl)thiazole Chemical Properties,Usage,Production
Synthesis
99-91-2
17356-08-0
73040-66-1
According to the method reported by Siddiqui et al [17], p-chloroacetophenone (0.01 mol) and thiourea (1.52 g, 0.02 mol) were used as raw materials and iodine (2.54 g, 0.01 mol) was added for the reaction. The reaction mixture was heated in an oil bath at 100 °C overnight. After completion of the reaction, it was cooled to room temperature and the reaction mixture was washed with diethyl ether (100 mL) to remove unreacted iodine and p-chloroacetophenone. The solid residue was dissolved in cold water (200 mL) and the pH was adjusted to 9-10 with 25% aqueous ammonium hydroxide.The precipitated 2-amino-5-(4-chlorophenyl)thiazole was collected by filtration and purified by recrystallization with hot ethanol. The product 2-amino-5-(4-chlorophenyl)thiazole (1) had a yield of 81% and a melting point of 168-170 °C. FTIR (KBr pressed sheet, cm?1 ): 3439, 3284 (NH?symmetric and asymmetric stretching vibrations), 1633 (C=N stretching vibration).1H NMR (DMSO-d?, 300 MHz, δ): 7.81-7.79 (d, 2H, benzene ring hydrogen), 7.41-7.38 (d, 2H, benzene ring hydrogen), 7.12 (s, 2H, NH?), 7.04 (s, 1H, thiazole ring hydrogen). Elemental analysis (calculated values, C?H?ClN?S, 210.5 g/mol): C, 51.31; H, 3.33; N, 13.30; S, 15.20. measured values: C, 51.55; H, 3.39; N, 13.50; S, 15.33.
References
[1] Synthesis and Reactivity in Inorganic, Metal-Organic and Nano-Metal Chemistry, 2015, vol. 45, # 4, p. 605 - 613
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