2-Phenyl-2-(1-piperidinyl)propane

ChemicalBook > CAS DataBase List > 2-Phenyl-2-(1-piperidinyl)propane

2-Phenyl-2-(1-piperidinyl)propane

Product Name: 2-Phenyl-2-(1-piperidinyl)propane
CAS No.: 92321-29-4
Chemical Name: 2-Phenyl-2-(1-piperidinyl)propane
Synonyms: PPP;Benzhexol Impurity 13;α-Dimethylbenzyl)piperidine;1-(α,α-DiMethylbenzyl)piperidine;1-(a,a-dimethylbenzyl)piperidine;2-Phenyl-2-(1-piperdinyl)propane;1-(2-Phenylpropan-2-yl)piperidine;2-phenyl-2-(1-piperidinyl)propane;1-(1-Methyl-1-phenylethyl)piperidine;Piperidine, 1-(1-methyl-1-phenylethyl)-
CBNumber: CB1247930
Molecular Formula: C14H21N
Formula Weight: 203.32
MOL File: 92321-29-4.mol

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2-Phenyl-2-(1-piperidinyl)propane Property

storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Oil
color: Colourless to Light Yellow

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 17799
Product name: 2-Phenyl-2-(1-piperidinyl)propane
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 17799
Product name: 2-Phenyl-2-(1-piperidinyl)propane
Purity: ≥95%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

Cayman Chemical

Product number: 17799
Product name: 2-Phenyl-2-(1-piperidinyl)propane
Purity: ≥95%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

Cayman Chemical

Product number: 17799
Product name: 2-Phenyl-2-(1-piperidinyl)propane
Purity: ≥95%
Packaging: 25mg
Price: $745
Updated: 2024/03/01

TRC

Product number: P336010
Product name: 2-Phenyl-2-(1-piperidinyl)propane
Packaging: 250mg
Price: $870
Updated: 2021/12/16

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2-Phenyl-2-(1-piperidinyl)propane Chemical Properties,Usage,Production

Description

2-Phenyl-2-(1-piperidinyl)propane is an analog of phencyclidine that acts as a mechanism-based inactivator of human cytochrome P450 (CYP) 2B6 (K_i = 5.6 μM; IC₅₀ = 5.1 μM). It is 15-fold more selective for inhibition of CYP2B6 over CYP2D6 and 40-60-fold more selective for CYP2B6 over CYP1A2, CYP2A6, CYP2Cs, and CYP3A.

Chemical Properties

Colorless to Light Yellow Oil

Uses

Enzyme inhibitor. A selective inactivator of CYP2B6.

in vitro

previous study found that 2-phenyl-2-(1-piperidinyl)propane could inactivate the 7-(benzyloxy)resorufin o-dealkylation activity of liver microsomes obtained from phenobarbital-induced rats. the 7-ethoxy-4-(trifluoromethyl)coumarin o-deethylation activity of purified rat liver p450 2b1 and expressed human p450 2b6 was also inactivated by 2-phenyl-2-(1-piperidinyl)propane in a reconstituted system. with nadph, the loss of activity was founf to be both time- and concentration-dependent, and followed pseudo first order kinetics. the time for 50% of the p450 2b1 to become inactivated at saturating concentrations of 2-phenyl-2-(1-piperidinyl)propane was ~2.5 min. p450 2b6 was inactivated by 2-phenyl-2-(1-piperidinyl)propane with a k(inact) of 0.07 min(-1), a k(i) of 1.2 microm, and a t(1/2) of 9.5 min. the inactivated p450s 2b1 and 2b6 lost about 25 and 15%, respectively, indicating that the loss of activity was caused by a 2-phenyl-2-(1-piperidinyl)propane modification of the apoprotein rather than the heme [1].

References

[1] chun j, kent um, moss rm, sayre lm, hollenberg pf. mechanism-based inactivation of cytochromes p450 2b1 and p450 2b6 by 2-phenyl-2-(1-piperidinyl)propane. drug metab dispos. 2000 aug;28(8):905-11.

2-Phenyl-2-(1-piperidinyl)propane Preparation Products And Raw materials

Raw materials

Preparation Products

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