1'-benzylspiro[indoline-3,4'-piperidine]

Product Name: 1'-benzylspiro[indoline-3,4'-piperidine]
CAS No.: 474538-99-3
Chemical Name: 1'-benzylspiro[indoline-3,4'-piperidine]
Synonyms: -Benzylspiro[indoline-3,4’1'-benzylspiro[indoline-3,4'-piperidine];1'-benzylspiro[1,2-dihydroindole-3,4'-piperidine];1'-benzyl-1,2-dihydrospiro[indole-3,4'-piperidine];1,2-dihydro-1'-(phenylmethyl)-Spiro[3H-indole-3,4'-piperidine];Spiro[3H-indole-3,4'-piperidine], 1,2-dihydro-1'-(phenylmethyl)-
CBNumber: CB12484348
Molecular Formula: C19H22N2
Formula Weight: 278.39
MOL File: 474538-99-3.mol

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1'-benzylspiro[indoline-3,4'-piperidine] Property

storage temp.: Sealed in dry,Room Temperature

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B289340
Product name: 1''-Benzylspiro[indoline-3,4''-piperidine]
Packaging: 250mg
Price: $595
Updated: 2021/12/16

Matrix Scientific

Product number: 057962
Product name: 1'-Benzylspiro[indoline-3,4'-piperidine]
Purity: 95%
Packaging: 1g
Price: $902
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0135363
Product name: 1'-BENZYLSPIRO[INDOLINE-3,4'-PIPERIDINE]
Purity: 95.00%
Packaging: 1G
Price: $1569.65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB141711
Product name: 1'-Benzylspiro[indoline-3,4'-piperidine]
Packaging: 500mg
Price: $340
Updated: 2021/12/16

AK Scientific

Product number: W6418
Product name: 1,2-Dihydro-1'-(phenylmethyl)-spiro[3h-indole-3,4'-piperidine]
Packaging: 1g
Price: $540
Updated: 2021/12/16

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1'-benzylspiro[indoline-3,4'-piperidine] Chemical Properties,Usage,Production

Synthesis

22065-85-6

100-63-0

474538-99-3

1. Preparation of Intermediate Compound 15: To a solution of phenylhydrazine (3.2 mL; 1.1 eq.) dissolved in toluene/acetonitrile (49/1, 50 mL) was slowly added trifluoroacetic acid (16.8 mL; 5 eq.) at room temperature. The reaction mixture was heated to 35 °C. Subsequently, a solution of 1-benzyl-4-piperidinecarboxaldehyde (6 g; 0.03 mol) in toluene/acetonitrile (49/1, 10 mL) was added slowly and dropwise. The reaction mixture was stirred at 35 °C overnight and then cooled to -10 °C. After addition of methanol (7 mL), sodium borohydride (1.7 g; 1.5 eq.) was added in batches. The mixture was continued to stir at room temperature for 1 hour. Upon completion of the reaction, 10% ammonia solution was added and the organic layer was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography (75 g SiO2, 35-70 μm; eluent: dichloromethane/methanol 98/2) to afford intermediate compound 15 (3.3 g, 40% yield).

References

[1] Patent: WO2005/97794, 2005, A1. Location in patent: Page/Page column 42

1'-benzylspiro[indoline-3,4'-piperidine] Preparation Products And Raw materials

Raw materials

Preparation Products

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1'-benzylspiro[indoline-3,4'-piperidine] Suppliers

China 33 India 1 United Kingdom 1 United States 5 Global 40

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