ChemicalBook > CAS DataBase List > [4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester

[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester

Product Name
[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester
CAS No.
497833-27-9
Chemical Name
[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester
Synonyms
Duvyzat;CS-2025;Gavinostat;Givinostat;Givinostat(ITF-2357);Givinostat(free base);(6-((Diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate;[6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate;[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester;Carbamic acid, [4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester
CBNumber
CB12484656
Molecular Formula
C24H27N3O4
Formula Weight
421.49
MOL File
497833-27-9.mol
More
Less

[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester Property

Density 
1.259
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
8.97±0.10(Predicted)
form 
Solid
color 
White to light yellow
InChI
InChI=1S/C24H27N3O4/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28)
InChIKey
YALNUENQHAQXEA-UHFFFAOYSA-N
SMILES
C(OCC1=CC=C2C(=C1)C=CC(CN(CC)CC)=C2)(=O)NC1=CC=C(C(NO)=O)C=C1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
KIN0000921
Product name
[4-[(HYDROXYAMINO)CARBONYL]PHENYL]CARBAMIC ACID [6-[(DIETHYLAMINO)METHYL]-2-NAPHTHALENYL]METHYL ESTER
Purity
95.00%
Packaging
5MG
Price
$816.75
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000921
Product name
[4-[(HYDROXYAMINO)CARBONYL]PHENYL]CARBAMIC ACID [6-[(DIETHYLAMINO)METHYL]-2-NAPHTHALENYL]METHYL ESTER
Purity
95.00%
Packaging
10MG
Price
$1006.58
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000921
Product name
[4-[(HYDROXYAMINO)CARBONYL]PHENYL]CARBAMIC ACID [6-[(DIETHYLAMINO)METHYL]-2-NAPHTHALENYL]METHYL ESTER
Purity
95.00%
Packaging
50MG
Price
$1734.23
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000921
Product name
[4-[(HYDROXYAMINO)CARBONYL]PHENYL]CARBAMIC ACID [6-[(DIETHYLAMINO)METHYL]-2-NAPHTHALENYL]METHYL ESTER
Purity
95.00%
Packaging
100MG
Price
$2583.16
Updated
2021/12/16
Crysdot
Product number
CD31001769
Product name
Givinostat
Purity
98+%
Packaging
10mg
Price
$260
Updated
2021/12/16
More
Less

[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester Chemical Properties,Usage,Production

Uses

Givinostat (ITF-2357) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively. Givinostat can be used for Duchenne muscular dystrophy (DMD) research[1].

Definition

ChEBI: N-[4-[(hydroxyamino)-oxomethyl]phenyl]carbamic acid [6-(diethylaminomethyl)-2-naphthalenyl]methyl ester is a carbamate ester.

in vivo

Givinostat (ITF2357) at 10 mg/kg is used as a positive control and, as expected, reduced serum TNFα by 60%. Strikingly, pretreatment of ITF3056 starting at 0.1 mg/kg significantly reduces the circulating TNFα by nearly 90%. To achieve a significant increase in serum IL-1β production, a higher dose of LPS is injected (10 mg/kg), and blood is collected after 4 h. Similarly, when pretreated with lower doses of Givinostat (ITF-2357) (1 or 5 mg/kg), there is a 22% reduction for 1 mg/kg and 40% for 5 mg/kg[1].

IC 50

hHDAC3: 157 nM (IC50); HD1-B: 7.5 nM (IC50); HD1-A: 16 nM (IC50); HD2: 10 nM (IC50); hHDAC1: 198 nM (IC50); hHDAC11: 292 nM (IC50); hHDAC6: 315 nM (IC50); hHDAC2: 325 nM (IC50); hHDAC10: 340 nM (IC50); hHDAC7: 524 nM (IC50); hHDAC5: 532 nM (IC50); hHDAC9: 541 nM (IC50); hHDAC8: 854 nM (IC50); hHDAC4: 1059 nM (IC50)

References

[1] Li S, et al. Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo. J Biol Chem. 2015 Jan 23;290(4):2368-78. DOI:10.1074/jbc.M114.618454
[2] Leoni F, et al. The histone deacetylase inhibitor ITF2357 reduces production of pro-inflammatory cytokines in vitro and systemic inflammation in vivo. Mol Med. 2005 Jan-Dec;11(1-12):1-15. DOI:10.2119/2006-00005.Dinarello
[3] Wang YG, et al. Givinostat inhibition of hepatic stellate cell proliferation and protein acetylation. World J Gastroenterol. 2015 Jul 21;21(27):8326-39. DOI:10.3748/wjg.v21.i27.8326

[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

[4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester Suppliers

China 85 United States 5 Global 90
Taizhou Nanfeng Pharmaceutical Research Institute
Tel
nanfengdrug@163.com; 18616377689
Email
nanfengdrug@163.com
Country
China
ProdList
20009
Advantage
58
Jiangsu Magic Biotechnology Co., Ltd
Tel
13921770081
Email
svp01@magicbiotech.cn
Country
China
ProdList
500
Advantage
58
Beijing Hope International Pharmaceutical Technology Development Co., Ltd
Tel
010-67887110-8057 15600038801
Fax
010-67887110-8016
Email
wuhangjin@hopelife.cn
Country
China
ProdList
20
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax
+86-27-87599188
Country
China
ProdList
1493
Advantage
55
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
SPIRO PHARMA
Tel
Fax
-
Email
eric_feng1954@126.com
Country
China
ProdList
316
Advantage
55
Pharmacodia (Beijing) Co.,Ltd
Tel
+86-400-851-9921
Fax
+86-10-82826195
Email
sales@pharmacodia.com
Country
China
ProdList
2317
Advantage
55
Shanghai Changyan Chem & Tech Co., Ltd.
Tel
021-20242659 18930833303
Fax
+86 (21) 2024-2659
Email
Sales@changyanchem.cn
Country
China
ProdList
5001
Advantage
55
Cangzhou Enke Pharma-tech Co., Ltd.
Tel
0317-5296180 15533709196
Fax
0317-5106596
Email
sale@enkepharma.com
Country
China
ProdList
2267
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Shanghai CR Corporation Limited
Tel
13062833949; 4006653949 4006653949
Fax
QQ: 2136646215
Email
fred.wen@crcorporation.cn
Country
China
ProdList
9756
Advantage
58
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28785
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3277
Advantage
58
Shanghai Medicil Biomedical Co., Ltd.
Tel
021-50822001
Email
marketing@medicilon.com.cn
Country
China
ProdList
1152
Advantage
58
Changzhou Yongfeng Biomedicine Co. Ltd.
Tel
15006117673
Fax
2973592490@.com
Email
2973592490@qq.com
Country
China
ProdList
299
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
Hefei Hirisun Pharmatech Co., Ltd
Tel
+8615056975894
Fax
86-0551-62678551
Email
shawn@hirisunpharm.com
Country
CHINA
ProdList
9911
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
CONIER CHEM AND PHARMA LIMITED
Tel
+8618523575427
Email
sales@conier.com
Country
China
ProdList
49975
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9814
Advantage
58
Wuhan Yanzhe Technology Co., Ltd
Tel
15527250409
Fax
QQ：2692360204
Email
wenhaotian12@163.com
Country
China
ProdList
4171
Advantage
58
Abmole Bioscience Inc.
Tel
021-50967598 02150967598
Email
sales@abmole.cn
Country
China
ProdList
4494
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
Tel
029-029-029-81148696 18161915376
Email
1040@dideu.com
Country
China
ProdList
10001
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
ProdList
9898
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
Advantage
58
Suzhou Haiben Pharmaceutical Co., Ltd
Tel
19353112242
Email
1816280386@qq.com
Country
China
ProdList
8045
Advantage
58
Foshan Heshuo Pharm technology Co., ltd
Tel
15363639686
Email
heshuoyiyao@hotmail.com
Country
China
ProdList
2376
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
Advantage
58
Beijing Taihe Jingming Pharmaceutical Technology Co., Ltd
Tel
15011440205
Email
2053813258@qq.com
Country
China
ProdList
165
Advantage
58
Anqing YanZhi Pharma Discovery Co.,Ltd.
Tel
18055651951
Email
2272561977@qq.com
Country
China
ProdList
435
Advantage
58
Zhengzhou Runkai Pharmaceutical Technology Co., Ltd
Tel
191-19137044811 19137644811
Email
3649307081@qq.com
Country
China
ProdList
500
Advantage
58
Sichuan Yiyan Pharmaceutical Research
Tel
19949968070; 19949968070
Email
2904199885@qq.com
Country
China
ProdList
913
Advantage
58
Hubei wei shi reagent group ltd., company
Tel
027-59101766 13125137661
Email
2853877621@qq.com
Country
China
ProdList
7975
Advantage
58
Guangzhou Brand-new Changshi Pharmaceutical Biotechnology Co., Ltd
Tel
19066311943
Email
815989315@qq.com
Country
China
ProdList
797
Advantage
58

497833-27-9, [4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl esterRelated Search:

ITF2357 2-((2-Chlorophenyl)(phenyl)aMino)-N-(7-(hydroxyaMino)-7-oxoheptyl)pyriMidine-5-carboxaMide

  • [4-[(Hydroxyamino)carbonyl]phenyl]carbamic acid [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester
  • Givinostat
  • Givinostat(ITF-2357)
  • Carbamic acid, N-[4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methylester
  • Gavinostat
  • [6-(diethylaminomethyl)naphthalen-2-yl]methyl N-[4-(hydroxycarbamoyl)phenyl]carbamate
  • CS-2025
  • Givinostat(free base)
  • Carbamic acid, [4-[(hydroxyamino)carbonyl]phenyl]-, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester
  • Duvyzat
  • (6-((Diethylamino)methyl)naphthalen-2-yl)methyl (4-(hydroxycarbamoyl)phenyl)carbamate
  • 497833-27-9