4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide

Product Name: 4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide
CAS No.: 870223-96-4
Chemical Name: 4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide
Synonyms: AMG-Tie2;AMG-Tie2-1;PubChem22413;AMG-Tie-2-1,AMGTie21,AMG Tie2 1;4-Methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)b;4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide;4-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide;Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-;870223-96-4; AMG-TIE2; AMG-TIE2-1; 4-METHYL-3-(3-(2-(METHYLAMINO)PYRIMIDIN-4-YL)PYRIDIN-2-YLOXY)-N-(3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE; 4-METHYL-3-[[3-[2-(METHYLAMINO)-4-PYRIMIDINYL]-2-PYRIDINYL]OXY]-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE; PUBCHEM22413
CBNumber: CB12484979
Molecular Formula: C25H20F3N5O2
Formula Weight: 479.45
MOL File: 870223-96-4.mol

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4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide Property

Density: 1.357
storage temp.: Store at -20°C
solubility: DMF: 10mg/mL; DMSO: 10mg/mL; DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL
form: A solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28850
Product name: AMG-Tie2-1
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 28850
Product name: AMG-Tie2-1
Packaging: 25mg
Price: $745
Updated: 2024/03/01

Cayman Chemical

Product number: 28850
Product name: AMG-Tie2-1
Packaging: 5mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 28850
Product name: AMG-Tie2-1
Packaging: 10mg
Price: $384
Updated: 2024/03/01

Adipogen Life Sciences

Product number: SYN-1008-M005
Product name: AMG-Tie2-1
Purity: ≥95%
Packaging: 5mg
Price: $421
Updated: 2021/12/16

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4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide Chemical Properties,Usage,Production

Description

AMG-Tie2-1 is an inhibitor of tunica interna endothelial cell kinase 2 (Tie2) and VEGF receptor 2 (VEGFR2) with IC₅₀ values of 1 and 3 nM, respectively, in a homogenous time-resolved fluorescence (HTRF) assay. It inhibits angiopoietin 1-induced Tie2 autophosphorylation in EA.hy926 human endothelial cells (IC₅₀ = 10 nM).

Uses

AMG-Tie 2-1 is a pyridinyltriazine Tie-2 kinase inhibitor. A useful research chemical for cancer metabolism research studies.

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide Suppliers

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870223-96-4, 4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamideRelated Search:

870223-96-4; AMG-TIE2; AMG-TIE2-1; 4-METHYL-3-(3-(2-(METHYLAMINO)PYRIMIDIN-4-YL)PYRIDIN-2-YLOXY)-N-(3-(TRIFLUOROMETHYL)PHENYL)BENZAMIDE; 4-METHYL-3-[[3-[2-(METHYLAMINO)-4-PYRIMIDINYL]-2-PYRIDINYL]OXY]-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE; PUBCHEM22413

PubChem22413

4-Methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]benzamide

AMG-Tie2-1

AMG-Tie2

4-methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)benzamide

4-Methyl-3-((3-(2-(methylamino)pyrimidin-4-yl)pyridin-2-yl)oxy)-N-(3-(trifluoromethyl)phenyl)b

Benzamide, 4-methyl-3-[[3-[2-(methylamino)-4-pyrimidinyl]-2-pyridinyl]oxy]-N-[3-(trifluoromethyl)phenyl]-

AMG-Tie-2-1,AMGTie21,AMG Tie2 1

870223-96-4

C25H20F3N5O2