ChemicalBook > CAS DataBase List > 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Product Name
- 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
- CAS No.
- 1012785-51-1
- Chemical Name
- 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Synonyms
- RW4063;2,4-Dichloro-5-iodo-7H-py...;2,4-DICHLORO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN;2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine;7H-Pyrrolo[2,3-d]pyrimidine, 2,4-dichloro-5-iodo-
- CBNumber
- CB12485466
- Molecular Formula
- C6H2Cl2IN3
- Formula Weight
- 313.91
- MOL File
- 1012785-51-1.mol
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2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine Property
- Melting point:
- 224 °C(Solv: dichloromethane (75-09-2))
- Density
- 2.337±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 8.78±0.50(Predicted)
- form
- powder
- color
- Light yellow
- CAS DataBase Reference
- 1012785-51-1
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Safety
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
TRC
- Product number
- D438543
- Product name
- 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR317008
- Product name
- 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $47
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-M-10
- Product name
- 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $52
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-M-10
- Product name
- 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 5G
- Price
- $154
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 112291
- Product name
- 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $284
- Updated
- 2021/12/16
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2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production
Synthesis
90213-66-4
1012785-51-1
General procedure for the synthesis of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidines using 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidines as starting material: 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidines (950 g, 5.053 mol) and dichloromethane (16 L) were added to a 50 L jacketed reactor. The resulting tan suspension was cooled to 16 °C and N-iodosuccinimide (1598 g, 7.104 mol) was added in batches over 20 min. The reaction mixture was stirred at room temperature for 16 h. Subsequently, the reaction was confirmed to be complete by thin-layer chromatography (TLC) analysis (unfolding agent ratio 2:1 hexane/ethyl acetate). The resulting precipitate was filtered, washed with dichloromethane (3 x 1.5 L) and dried under reduced pressure at 40 °C for 64 h to afford 1447 g (yield: 91%) of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine as a beige solid. Mass spectrum (ESI) m/z 314.0 [M + 1]+.
References
[1] Patent: US2014/200206, 2014, A1. Location in patent: Paragraph 0221
[2] Helvetica Chimica Acta, 2008, vol. 91, # 6, p. 1083 - 1105
[3] Patent: WO2018/85833, 2018, A2. Location in patent: Paragraph 0443
[4] Patent: US2009/54425, 2009, A1. Location in patent: Page/Page column 30-31
[5] Patent: WO2009/131687, 2009, A2. Location in patent: Page/Page column 98
2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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