7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
- Product Name
- 7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
- CAS No.
- 1005206-17-6
- Chemical Name
- 7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
- Synonyms
- 7H-Pyrrolo[2,3-d]pyrimidi...;7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
- CBNumber
- CB12485572
- Molecular Formula
- C7H5N3O2
- Formula Weight
- 163.13
- MOL File
- 1005206-17-6.mol
7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid Property
- storage temp.
- Storage temp. -20°C
- Appearance
- White to light yellow Solid
- CAS DataBase Reference
- 1005206-17-6
Safety
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B529835
- Product name
- 7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 070803
- Product name
- 7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- OR308079
- Product name
- 7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
- Packaging
- 250mg
- Price
- $412
- Updated
- 2021/12/16
- Product number
- 070803
- Product name
- 7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- CHM0391597
- Product name
- 7H-PYRROLO-[2,3-D]PYRIMIDINE-4-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.68
- Updated
- 2021/12/16
7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid Chemical Properties,Usage,Production
Synthesis
1095822-17-5
1005206-17-6
Synthesis of compound 1. A solution of lithium hydroxide (LiOH, 0.236 g, 10.2 mmol) in water (4 mL) was slowly added dropwise to a solution of methyl 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylate (1.4 g, 7.9 mmol) in tetrahydrofuran (THF, 20 mL) at 0 °C. The reaction mixture was stirred at 0 °C for 1 hour. Subsequently, the reaction solution was acidified with concentrated hydrochloric acid to pH 2. THF was evaporated off under reduced pressure and the remaining aqueous solution was cooled to 0 °C. The reaction was purified by filtration. The precipitated white solid was collected by filtration and dried under vacuum to afford 7H-pyrrolo[2,3-d]pyrimidine-4-carboxylic acid (Compound 1, 1.1 g, 85% yield). The product was characterized by 1H NMR (200 MHz, DMSO-d6): δ= 12.80 (broad peak, 1H), 8.95 (single peak, 1H), 7.87 (double peak, J = 2.8 Hz, 1H), 6.96 (double peak, J = 2.8 Hz, 1H). The mass spectrum (MS) showed m/z 164 [M + H]+.
References
[1] Patent: US2009/5359, 2009, A1. Location in patent: Page/Page column 16
7H-Pyrrolo[2,3-d]pyrimidine-4-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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