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UBP310

Product Name
UBP310
CAS No.
902464-46-4
Chemical Name
UBP310
Synonyms
UBP310;UBP310, GluK1 and GluK3 selective antagonist;receptor,glutamate,inhibit,UBP310,Ionotropic glutamate receptors,GluR5,Inhibitor,UBP-310,iGluR;(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione;1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxy-3-thienyl)methyl]-3,4-dihydro-5-methyl-2,4-dioxo-, (αS)-
CBNumber
CB12487581
Molecular Formula
C14H15N3O6S
Formula Weight
353.35
MOL File
902464-46-4.mol
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UBP310 Property

Melting point:
226-228 °C (decomp)(Solv: water (7732-18-5))
Boiling point:
615.2±65.0 °C(Predicted)
Density 
1.564±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
DMSO: Slightly Soluble
form 
A crystalline solid
pka
2.12±0.10(Predicted)
color 
White to off-white
InChI
1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
InChIKey
ZTAZUCRXCRXNSU-VIFPVBQESA-N
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Safety

WGK Germany 
WGK 2
Storage Class
11 - Combustible Solids
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
5.05017
Product name
UBP310 - CAS 902464-46-4 - Calbiochem
Packaging
10MG
Price
$179
Updated
2022/05/15
Cayman Chemical
Product number
21806
Product name
UBP 310
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
21806
Product name
UBP 310
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
21806
Product name
UBP 310
Purity
≥98%
Packaging
10mg
Price
$172
Updated
2024/03/01
Tocris
Product number
3621
Product name
UBP310
Purity
≥98%(HPLC)
Packaging
10
Price
$184
Updated
2021/12/16
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UBP310 Chemical Properties,Usage,Production

Description

UBP 310 is an antagonist of ionotropic glutamate receptor 5 (GluR5 or GluK1; Kd = 130 nM). It less potently binds GluR2 (GluA2) and GluR6 (GluK2; Kds = 106 and 1,626 μM, respectively). UBP 310 is inactive at metabotropic GluR group I and NMDA receptors.

Uses

UBP 310 is a GLUK5 kainate receptor antagonist.

storage

Store at +4°C

References

[1] PALMI T ATLASON. Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310.[J]. ACS Applied Electronic Materials, 2010: 1036-1045. DOI: 10.1124/mol.110.067934
[2] MARK L MAYER. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.[J]. ACS Applied Energy Materials, 2006: 2852-2861. DOI: 10.1523/jneurosci.0123-06.2005
[3] DAVID PERRAIS . Antagonism of recombinant and native GluK3-containing kainate receptors[J]. Neuropharmacology, 2009, 56 1: Pages 131-140. DOI: 10.1016/j.neuropharm.2008.08.002
[4] MEI DU V J Anu Rambhadran. Luminescence resonance energy transfer investigation of conformational changes in the ligand binding domain of a kainate receptor.[J]. The Journal of Biological Chemistry, 2008, 283 40: 27074-27078. DOI: 10.1074/jbc.m805040200

UBP310 Preparation Products And Raw materials

Raw materials

Preparation Products

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UBP310 Suppliers

CHINA 36 United Kingdom 2 United States 8 USA 1 Global 47
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
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China
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15838
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Ascent Scientific
Tel
4401179829988
Fax
4402030 700 369
Email
customerservice@ascentscientific.co.uk
Country
United Kingdom
ProdList
279
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60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32470
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
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11218
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MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8140
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
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China
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29757
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Kaifeng Mingren Pharmaceutical Co.,LTD
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0371-65741762
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QQ：2860768577
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sales@hasunny.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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24963
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Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 18100677375
Email
sales@szzxbio.com
Country
China
ProdList
2993
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58

902464-46-4, UBP310Related Search:


  • UBP310
  • (S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
  • receptor,glutamate,inhibit,UBP310,Ionotropic glutamate receptors,GluR5,Inhibitor,UBP-310,iGluR
  • 1(2H)-Pyrimidinepropanoic acid, α-amino-3-[(2-carboxy-3-thienyl)methyl]-3,4-dihydro-5-methyl-2,4-dioxo-, (αS)-
  • UBP310, GluK1 and GluK3 selective antagonist
  • 902464-46-4
  • Glutamate