2-Amino-6-bromothiazolo[5,4-b]pyridine

Uses

Product Name: 2-Amino-6-bromothiazolo[5,4-b]pyridine
CAS No.: 1160791-13-8
Chemical Name: 2-Amino-6-bromothiazolo[5,4-b]pyridine
Synonyms: 2-Amino-6-bromothiazolo[5,4-b]pyridine;Thiazolo[5,4-b]pyridin-2-amine, 6-bromo-;6-BroMo-thiazolo[5,4-b]pyridin-2-ylaMine;6-bromo-[1,3]thiazolo[5,4-b]pyridin-2-amine
CBNumber: CB12489646
Molecular Formula: C6H4BrN3S
Formula Weight: 230.09
MOL File: 1160791-13-8.mol

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2-Amino-6-bromothiazolo[5,4-b]pyridine Property

Boiling point:: 362.1±45.0 °C(Predicted)
Density: 1.950±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 0.79±0.40(Predicted)
Appearance: Light brown to brown Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A595193
Product name: 2-Amino-6-bromothiazolo[5,4-b]pyridine
Packaging: 100mg
Price: $90
Updated: 2021/12/16

AK Scientific

Product number: X9148
Product name: 2-Amino-6-bromothiazolo[5,4-b]pyridine
Packaging: 250mg
Price: $211
Updated: 2021/12/16

Matrix Scientific

Product number: 073841
Product name: 2-Amino-6-bromothiazolo[5,4-b]pyridine
Purity: 95+%
Packaging: 500mg
Price: $364
Updated: 2021/12/16

Matrix Scientific

Product number: 073841
Product name: 2-Amino-6-bromothiazolo[5,4-b]pyridine
Purity: 95+%
Packaging: 1g
Price: $560
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0043835
Product name: 6-BROMOTHIAZOLO[5,4-B]PYRIDIN-2-AMINE
Purity: 95.00%
Packaging: 250MG
Price: $1066.07
Updated: 2021/12/16

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2-Amino-6-bromothiazolo[5,4-b]pyridine Chemical Properties,Usage,Production

Uses

2-Amino-6-bromothiazo[5,4-B]pyridine is an organic intermediate that can be prepared in one step from 5-bromo-2-chloropyridine-3-amine and potassium thiocyanate, or in three steps from 3-amino-5-bromo-2-fluoropyridine and benzoyl isothiocyanate.

Synthesis

588730-01-2

1160791-13-8

General procedure for the synthesis of 2-amino-6-bromothiazolo[5,4-b]pyridin-2-yl from N-(6-bromothiazolo[5,4-b]pyridin-2-yl)benzamide: Dissolve N-(6-bromothiazolo[5,4-b]pyridin-2-yl)benzamide (2.0 g, 5.98 mmol) in 70% sulfuric acid (10.0 mL) and react by heating to 140 °C for 1 hour. Upon completion of the reaction (monitored by TLC), the reaction mixture was poured into crushed ice and the pH was adjusted to 8.0 with 30% aqueous sodium hydroxide, followed by extraction with ethyl acetate (3 x 150 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to afford the target product 2-amino-6-bromothiazolo[5,4-b]pyridine (1.34 g, 98% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 7.85 (d, J=2.0 Hz, 1H), 8.05 (br s, 2H), 8.18 (d, J=2.0 Hz, 1H).

References

[1] Patent: WO2009/74812, 2009, A1. Location in patent: Page/Page column 91; 92

2-Amino-6-bromothiazolo[5,4-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Amino-6-bromothiazolo[5,4-b]pyridine Suppliers

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1160791-13-8, 2-Amino-6-bromothiazolo[5,4-b]pyridineRelated Search:

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