2,5-Dichloro-4-methylpyrimidine
- Product Name
- 2,5-Dichloro-4-methylpyrimidine
- CAS No.
- 1192064-63-3
- Chemical Name
- 2,5-Dichloro-4-methylpyrimidine
- Synonyms
- 2,5-Dichloro-4-methylpyrimidine;Pyrimidine, 2,5-dichloro-4-methyl-;2,5-Dichloro-4-methylpyrimidine ISO 9001：2015 REACH
- CBNumber
- CB12490828
- Molecular Formula
- C5H4Cl2N2
- Formula Weight
- 163
- MOL File
- 1192064-63-3.mol
2,5-Dichloro-4-methylpyrimidine Property
- Boiling point:
- 256.9±20.0 °C(Predicted)
- Density
- 1.404±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.35±0.29(Predicted)
- Appearance
- White to light green Solid
Safety
- HS Code
- 2933599590
N-Bromosuccinimide Price
- Product number
- D474713
- Product name
- 2,5-Dichloro-4-methylpyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR906028
- Product name
- 2,5-Dichloro-4-methylpyrimidine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $254
- Updated
- 2021/12/16
- Product number
- 3H32-5-QH
- Product name
- 2,5-Dichloro-4-methylpyrimidine
- Purity
- 96%
- Packaging
- 250mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- OR906028
- Product name
- 2,5-Dichloro-4-methylpyrimidine
- Purity
- 96%
- Packaging
- 1g
- Price
- $631
- Updated
- 2021/12/16
- Product number
- 3H32-5-QH
- Product name
- 2,5-Dichloro-4-methylpyrimidine
- Purity
- 96%
- Packaging
- 1g
- Price
- $696
- Updated
- 2021/12/16
2,5-Dichloro-4-methylpyrimidine Chemical Properties,Usage,Production
Synthesis
75-16-1
5750-76-5
1192064-63-3
Intermediate 13: Synthesis of 2,5-dichloro-4-methylpyrimidine. To a THF/NMP (86 mL/6 mL) solution of 2,4,5-trichloropyrimidine (2.52 g, 13.74 mmol) was added Fe(acac)3 (485 mg, 1.37 mmol) and the mixture was cooled to 0 °C. An ether solution of 3.0 M methylmagnesium bromide (6.87 mL, 20.61 mmol) was added slowly and dropwise. After 30 min at 0 °C, the reaction was quenched with saturated aqueous ammonium chloride solution. Ether was added to separate the organic and aqueous layers, and the aqueous layer was extracted with ether several times. The organic extracts were combined, dried with anhydrous sodium sulfate, filtered and concentrated in vacuum. Purification by column chromatography (n-hexane to 10% ethyl acetate/hexane gradient elution) afforded the target product 2,5-dichloro-4-methylpyrimidine as a white solid (1.45 g, 65% yield).1H NMR (500 MHz, CDCl3): δ 8.47 (s, 1H), 2.61 (s, 3H).
References
[1] Patent: WO2011/50202, 2011, A1. Location in patent: Page/Page column 57
[2] Patent: WO2011/75560, 2011, A1. Location in patent: Page/Page column 58
2,5-Dichloro-4-methylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2,5-Dichloro-4-methylpyrimidine Suppliers
- Tel
- 021-31261262/ 49 (0)17662837245
- Fax
- (0)21-33250524
- sales@novochemy.com
- Country
- Germany
- ProdList
- 6328
- Advantage
- 58
View Lastest Price from 2,5-Dichloro-4-methylpyrimidine manufacturers
- Product
- 2,5-Dichloro-4-methylpyrimidine 1192064-63-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-07