Catechin 7-o-beta-D-xyloside
- Product Name
- Catechin 7-o-beta-D-xyloside
- CAS No.
- 65597-47-9
- Chemical Name
- Catechin 7-o-beta-D-xyloside
- Synonyms
- C09617;Catechin 7-o-beta-D-xyloside;Catechin7-O-β-D-glucopyranoside;(2R,3S)-catechin 7-O-β-D-glucopyranoside
- CBNumber
- CB12496284
- Molecular Formula
- C20H22O10
- Formula Weight
- 422.38268
- MOL File
- 65597-47-9.mol
Catechin 7-o-beta-D-xyloside Property
- form
- Solid
- color
- White to off-white
Catechin 7-o-beta-D-xyloside Chemical Properties,Usage,Production
Uses
Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research[1][2][3].
Definition
ChEBI: (+)-catechin 7-O-beta-D-xyloside is a monosaccharide derivative that is (+)-catechin substituted by a beta-D-xylopyranosyl moiety at position 7 via a glycosidic linkage. It is a beta-D-xyloside and a monosaccharide derivative. It is functionally related to a (+)-catechin.
in vivo
Catechin 7-O-β-D-glucopyranoside (intraperitoneal injection; 10 mg/kg; once) treatment shows mild protective effect against lethality induced by LPS/D-GalN[1].
Catechin 7-O-β-D-glucopyranoside (oral administration; 10 mg/kg; once daily; 7 d) treatment prevents intestinal inflammatory damages in TNBS model of rat colitis[2].
| Animal Model: | Mice injected with LPS/D-GalN[1] |
| Dosage: | 10 mg/kg |
| Administration: | Intraperitoneal injection; 10 mg/kg; once |
| Result: | Showed 80% LPS/DGalN-induced lethality in mice. |
| Animal Model: | Rat model of trinitrobenzenesulfonic acid (TNBS)-induced colitis [2] |
| Dosage: | 10 mg/kg |
| Administration: | Oral administration; 10 mg/kg; once daily; 7 days |
| Result: | Suppressed body weight loss and intestinal inflammatory damages in TNBS-induced colitic rats. Reduced myeloperoxidase activity and malondialdehyde level, but increased glutathione level in the TNBS colitic rats. |
References
[1] Zheng MS, et al. Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica. Arch Pharm Res. 2011 Sep;34(9):1443-50. DOI:10.1007/s12272-011-0905-6
[2] Kook SH, et al. Catechin-7-O-β-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats. Int Immunopharmacol. 2015 Dec;29(2):521-527. DOI:10.1016/j.intimp.2015.10.003
[3] Kim KC, et al. Cytoprotective effects of catechin 7-O-β-D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells. Cell Biochem Funct. 2010 Dec 2;28(8):651-60. DOI:10.1002/cbf.1703
Catechin 7-o-beta-D-xyloside Preparation Products And Raw materials
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